FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315752562> ?p ?o ?g. }

• W4315752562 endingPage "515" @default.
• W4315752562 startingPage "508" @default.
• W4315752562 abstract "Objective: The aim of this study was to assess the reduction in all-cause death and cardiovascular outcomes associated with the administration of the thiazide-like diuretic indapamide monotherapy or in combination with perindopril as a blood pressure lowering drug in randomized controlled trials (RCTs). Method: Aggregate data from four published RCTs conducted versus matching placebo were pooled: PATS, a 2-year study (indapamide), and PROGRESS, a 4-year study (indapamide and perindopril), both in patients with a history of stroke or transient ischemic attack; ADVANCE, a 4-year study in patients with type 2 diabetes and cardiovascular risk factor (single-pill combination perindopril/indapamide) and HYVET, a 2-year study in very elderly hypertensive individuals (indapamide and an option of perindopril). The pooled effect (fixed and random) estimate (hazard ratio) was reported with corresponding 95% confidence intervals and P values. Treatment discontinuations were also analysed to assess the net benefit of the treatment. Results: The population involved 24 194 patients (active: 12 113, placebo: 12 081). The fixed-effects meta-analysis of the three mortality endpoints found low statistical heterogeneity ( I 2 = 0). Statistically significant risk reductions in the indapamide with or without perindopril-treated patients as compared to placebo were observed for all-cause death (−15%), cardiovascular death (−21%), fatal stroke (−36%) and all strokes (−27%). Other cardiovascular outcomes were improved (risk reduction, 22 to 36%). As expected, discontinuation rates for safety (two studies) were higher in the active group (6.4 vs. 3.9%), while they were similar when discontinuation for any reason is concerned (18.4 vs. 18.0%). Conclusion: Across medium to high cardiovascular risk population, long-term indapamide, mostly combined with perindopril-based treatment, provided evidence of benefit on mortality and morbidity." @default.
• W4315752562 created "2023-01-13" @default.
• W4315752562 creator A5003836717 @default.
• W4315752562 creator A5028308949 @default.
• W4315752562 creator A5044426809 @default.
• W4315752562 creator A5049190768 @default.
• W4315752562 creator A5084756058 @default.
• W4315752562 date "2023-01-19" @default.
• W4315752562 modified "2023-10-14" @default.
• W4315752562 title "Benefit of treatment based on indapamide mostly combined with perindopril on mortality and cardiovascular outcomes: a pooled analysis of four trials" @default.
• W4315752562 cites W1495136860 @default.
• W4315752562 cites W1497461844 @default.
• W4315752562 cites W1520254567 @default.
• W4315752562 cites W1592471891 @default.
• W4315752562 cites W189378711 @default.
• W4315752562 cites W1924870810 @default.
• W4315752562 cites W1997676932 @default.
• W4315752562 cites W2009868110 @default.
• W4315752562 cites W2011713510 @default.
• W4315752562 cites W2013354239 @default.
• W4315752562 cites W2020362859 @default.
• W4315752562 cites W2020608625 @default.
• W4315752562 cites W2054796764 @default.
• W4315752562 cites W2062638986 @default.
• W4315752562 cites W2081372556 @default.
• W4315752562 cites W2093926139 @default.
• W4315752562 cites W2103881469 @default.
• W4315752562 cites W2111844910 @default.
• W4315752562 cites W2117529378 @default.
• W4315752562 cites W2124909544 @default.
• W4315752562 cites W2129832544 @default.
• W4315752562 cites W2133416234 @default.
• W4315752562 cites W2134612278 @default.
• W4315752562 cites W2140854783 @default.
• W4315752562 cites W2143954917 @default.
• W4315752562 cites W2150959326 @default.
• W4315752562 cites W2157677292 @default.
• W4315752562 cites W2160674513 @default.
• W4315752562 cites W2191304082 @default.
• W4315752562 cites W2198866495 @default.
• W4315752562 cites W2299635245 @default.
• W4315752562 cites W2323393982 @default.
• W4315752562 cites W2333797217 @default.
• W4315752562 cites W2437822687 @default.
• W4315752562 cites W2509102166 @default.
• W4315752562 cites W2519397310 @default.
• W4315752562 cites W2588787215 @default.
• W4315752562 cites W2593668474 @default.
• W4315752562 cites W2607031541 @default.
• W4315752562 cites W2663998548 @default.
• W4315752562 cites W2750594649 @default.
• W4315752562 cites W2768267412 @default.
• W4315752562 cites W2782397703 @default.
• W4315752562 cites W2888589263 @default.
• W4315752562 cites W2924479289 @default.
• W4315752562 cites W3006355415 @default.
• W4315752562 cites W3021351037 @default.
• W4315752562 cites W3021406499 @default.
• W4315752562 cites W3023969949 @default.
• W4315752562 cites W3055480650 @default.
• W4315752562 cites W3088089537 @default.
• W4315752562 cites W3121057017 @default.
• W4315752562 cites W3132628433 @default.
• W4315752562 cites W3197233987 @default.
• W4315752562 cites W4246475368 @default.
• W4315752562 cites W4282944211 @default.
• W4315752562 cites W4290764607 @default.
• W4315752562 doi "https://doi.org/10.1097/hjh.0000000000003368" @default.
• W4315752562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36633311" @default.
• W4315752562 hasPublicationYear "2023" @default.
• W4315752562 type Work @default.
• W4315752562 citedByCount "2" @default.
• W4315752562 countsByYear W43157525622023 @default.
• W4315752562 crossrefType "journal-article" @default.
• W4315752562 hasAuthorship W4315752562A5003836717 @default.
• W4315752562 hasAuthorship W4315752562A5028308949 @default.
• W4315752562 hasAuthorship W4315752562A5044426809 @default.
• W4315752562 hasAuthorship W4315752562A5049190768 @default.
• W4315752562 hasAuthorship W4315752562A5084756058 @default.
• W4315752562 hasBestOaLocation W43157525621 @default.
• W4315752562 hasConcept C126322002 @default.
• W4315752562 hasConcept C127413603 @default.
• W4315752562 hasConcept C142724271 @default.
• W4315752562 hasConcept C164705383 @default.
• W4315752562 hasConcept C204787440 @default.
• W4315752562 hasConcept C207103383 @default.
• W4315752562 hasConcept C27081682 @default.
• W4315752562 hasConcept C2777748223 @default.
• W4315752562 hasConcept C2778715236 @default.
• W4315752562 hasConcept C2779200603 @default.
• W4315752562 hasConcept C2780437262 @default.
• W4315752562 hasConcept C2780645631 @default.
• W4315752562 hasConcept C44249647 @default.
• W4315752562 hasConcept C71924100 @default.
• W4315752562 hasConcept C78519656 @default.
• W4315752562 hasConcept C84393581 @default.
• W4315752562 hasConceptScore W4315752562C126322002 @default.
• W4315752562 hasConceptScore W4315752562C127413603 @default.

• next