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- W4315752612 abstract "Abstract Ethoxysanguinarine (ESG) is a benzophenanthridine alkaloid extracted from plants of Papaveraceae family, such as Macleaya cordata (Willd) R. Br. The anti‐cancer activity of ESG has been rarely reported. In this study, we investigated the anti‐breast cancer effect of ESG and its underlying mechanism. MTT assay and flow cytometry analysis showed that ESG inhibited the viability and induced apoptosis in MCF7 and MDA‐MB‐231 human breast cancer cells. Western blot revealed that ESG triggered intrinsic and extrinsic apoptotic pathways, as evidenced by the activation of caspase‐8, caspase‐9 and caspase‐3. ESG attenuated breast cancer cell migration and invasion through Hakai/E‐cadherin/N‐cadherin. Moreover, Hakai knockdown sensitized ESG‐triggered viability and motility inhibition, suggesting that Hakai mediated the anti‐breast cancer effect of ESG. In addition, ESG potentiated the anti‐cancer activity of docetaxel (DTX) in breast cancer cells. Overall, our findings demonstrate that ESG exhibits outstanding pro‐apoptosis and anti‐metastasis effects on breast cancer via a mechanism related to Hakai‐related signaling pathway." @default.
- W4315752612 created "2023-01-13" @default.
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- W4315752612 date "2023-01-23" @default.
- W4315752612 modified "2023-10-14" @default.
- W4315752612 title "Ethoxysanguinarine Induces Apoptosis, Inhibits Metastasis and Sensitizes cells to Docetaxel in Breast Cancer Cells through Inhibition of Hakai" @default.
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- W4315752612 doi "https://doi.org/10.1002/cbdv.202200284" @default.
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