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- W4315753869 endingPage "269" @default.
- W4315753869 startingPage "257" @default.
- W4315753869 abstract "Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range = 18-41 years) were included. For all tasks combined, the ASD group showed significant (p < .05) hypo-activation in one cluster around the left amygdala (peak - 26, -2, -20, volume = 1336 mm3, maximum ALE = 0.0327), and this cluster co-activated with two other clusters around the right cerebellum (peak 42, -56, -22, volume = 2560mm3, maximum ALE = 0.049) Lobule VI/Crus I and the left fusiform gyrus (BA47) (peak - 42, -46, -18, volume = 1616 mm3, maximum ALE = 0.046) and left cerebellum (peak - 42, -58, -20, volume = 1616mm3, maximum ALE = 0.033) Lobule VI/Crus I. While the left amygdala was associated with negative emotion (fear) (z = 3.047), the left fusiform gyrus/cerebellum Lobule VI/Crus I cluster was associated with language semantics (z = 3.724) and action observation (z = 3.077). These findings highlight the left amygdala as a region consistently hypo-activated in ASD and suggest the potential involvement of fusiform gyrus and cerebellum in social cognition in ASD. Future research should further elucidate if and how amygdala-fusiform/cerebellar connectivity relates to social and non-social cognition in adults with ASD." @default.
- W4315753869 created "2023-01-13" @default.
- W4315753869 creator A5014310950 @default.
- W4315753869 creator A5027340160 @default.
- W4315753869 creator A5028572478 @default.
- W4315753869 creator A5042926603 @default.
- W4315753869 creator A5061002947 @default.
- W4315753869 creator A5070040543 @default.
- W4315753869 creator A5077932941 @default.
- W4315753869 date "2023-01-12" @default.
- W4315753869 modified "2023-10-07" @default.
- W4315753869 title "Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders" @default.
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