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• W4315754003 endingPage "119431" @default.
• W4315754003 startingPage "119431" @default.
• W4315754003 abstract "During heat stress (HS), the intestinal epithelium suffers damage due to imbalance of tissue homeostasis. However, the specific mechanism by which intestinal stem cells (ISCs) migrate and differentiate along the crypt–villus axis to heal lesions upon insult is unclear. In our study, C57BL/6 mice and IPEC-J2 cells were subjected to normal ambient conditions (25 °C for 7 days in vivo and 37 °C for 18 h in vitro) or 41 °C. The results showed that HS impaired intestinal morphology and barrier function. The numbers of ISCs (SOX9+ cells), mitotic cells (PCNA+ cells), and differentiated cells (Paneth cells marked by lysozyme, absorptive cells marked by Villin, goblet cells marked by Mucin2, enteroendocrine cells marked by Chromogranin A, and tuft cells marked by DCAMKL1) were reduced under high temperature. Importantly, BrdU incorporation confirmed the decreased migration ability of jejunal epithelial cells exposed to 41 °C. Furthermore, intestinal organoids (IOs) expanded from jejunal crypt cells in the HS group exhibited greater growth disadvantages. Mechanistically, the occurrence of these phenotypes was accompanied by FAK/paxillin/F-actin signaling disruption in the jejunum. The fact that the FAK agonist ZINC40099027 reversed the HS-triggered inhibition of IPEC-J2 cell differentiation and migration further confirmed the dominant role of FAK in response to high-temperature conditions. Overall, the present investigation is the first to reveal a major role of FAK/paxillin/F-actin signaling in HS-induced ISC migration and differentiation along the crypt–villus axis, which indicates a new therapeutic target for intestinal epithelial regeneration after heat injuries." @default.
• W4315754003 created "2023-01-13" @default.
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• W4315754003 date "2023-03-01" @default.
• W4315754003 modified "2023-10-16" @default.
• W4315754003 title "Heat stress disrupts intestinal stem cell migration and differentiation along the crypt–villus axis through FAK signaling" @default.
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• W4315754003 doi "https://doi.org/10.1016/j.bbamcr.2023.119431" @default.
• W4315754003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36632926" @default.
• W4315754003 hasPublicationYear "2023" @default.
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