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- W4315754584 abstract "Circulating levels of interleukin-17 (IL-17) are associated with the presence and severity of periodontitis. However, whether IL-17 is causal for disease development is unknown. We investigated the effect of genetically proxied IL-17 on periodontitis using instrumental variable analysis.We identified 12 genetic variants from genome-wide association study (GWAS) of 7760 European descent individuals, used these variants as instrumental variables for IL-17, and linked them to a GWAS of 17,353 clinical periodontitis cases and 28,210 European controls. Generalized weighted least squares analysis accounted for linkage disequilibrium of variants.We found an inverse association of genetically proxied IL-17 and periodontitis (odds ratio, 0.84; 95% confidence interval: 0.75-0.94; p = 0.003), which was corroborated after sensitivity analysis for horizontal pleiotropy.The findings suggest that IL-17 protects against initial periodontitis." @default.
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- W4315754584 date "2023-01-30" @default.
- W4315754584 modified "2023-09-26" @default.
- W4315754584 title "Effect of interleukin‐17 on periodontitis development: An instrumental variable analysis" @default.
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- W4315754584 doi "https://doi.org/10.1002/jper.22-0365" @default.
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