Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315778889> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4315778889 endingPage "e266" @default.
- W4315778889 startingPage "e265" @default.
- W4315778889 abstract "Introduction: We reported that antihypertensive therapy with a hydrochlorothiazide (HCTZ)-based regimen aggravates arterial stiffness and vascular calcification in a rat model of chronic kidney disease (CKD) with mineral and bone disorder (MBD). In this study, we investigated whether the aggravation of arterial stiffness and vascular calcification in CKD-MBD rats is induced by HCTZ and whether these abnormalities could also occur with other types of diuretic currently used in clinic. Methods: In rats with renal mass ablation-induced CKD, MBD was generated by a Ca/P-rich diet and calcitriol supplementation. The animals were divided into 4 groups; 1) CKD-MBD control; 2) CKD-MBD + HCTZ (thiazide diuretic, 5 mg/kg/d); 3) CKD-MBD + Chlorthalidone (thiazide-like diuretic, 5 mg/kg/d), and; 4) CKD-MBD + Furosemide (loop diuretics, 10 mg/kg/d). At week 6, hemodynamic parameters including systolic and mean blood pressure (SBP and MBP), pulse pressure (PP) and pulse wave velocity (PWV) were determined. The thoracic aorta was harvested to assess vascular calcification.Results: SBP was reduced by all types of diuretic in CKD-MBD rats. Contrary to chlortalidone nor furosemide, HCTZ treatment led to a reduction of MBP, but an increase in PP and PWV in CKD-MBD rats (p < 0.05). As expected from these hemodynamic changes, medial calcification in the thoracic aorta was significantly greater in CKD-MBD rats treated with HCTZ as compared to all the other groups of rats (p < 0.05). Conclusion: In rats with CKD-MBD, antihypertensive therapy with the thiazide diuretic HCTZ, but not other types of diuretic, exacerbated arterial stiffness and vascular calcification despite a reduction in SBP. The deleterious effect of HCTZ in CKD-MBD rats may have major clinical impact as this diuretic is widely use in patients with CKD that often develop MBD." @default.
- W4315778889 created "2023-01-13" @default.
- W4315778889 creator A5021599795 @default.
- W4315778889 creator A5024025047 @default.
- W4315778889 creator A5064944124 @default.
- W4315778889 creator A5066886576 @default.
- W4315778889 creator A5069495753 @default.
- W4315778889 creator A5071478665 @default.
- W4315778889 creator A5088680224 @default.
- W4315778889 date "2023-01-01" @default.
- W4315778889 modified "2023-10-04" @default.
- W4315778889 title "PS-BPB01-8: IMPACT OF DIFFERENT DIURETIC TYPES ON ARTERIAL STIFFNESS AND CALCIFICATION IN A RAT MODEL OF CHRONIC KIDNEY DISEASE" @default.
- W4315778889 doi "https://doi.org/10.1097/01.hjh.0000915444.39211.1a" @default.
- W4315778889 hasPublicationYear "2023" @default.
- W4315778889 type Work @default.
- W4315778889 citedByCount "0" @default.
- W4315778889 crossrefType "journal-article" @default.
- W4315778889 hasAuthorship W4315778889A5021599795 @default.
- W4315778889 hasAuthorship W4315778889A5024025047 @default.
- W4315778889 hasAuthorship W4315778889A5064944124 @default.
- W4315778889 hasAuthorship W4315778889A5066886576 @default.
- W4315778889 hasAuthorship W4315778889A5069495753 @default.
- W4315778889 hasAuthorship W4315778889A5071478665 @default.
- W4315778889 hasAuthorship W4315778889A5088680224 @default.
- W4315778889 hasBestOaLocation W43157788891 @default.
- W4315778889 hasConcept C126322002 @default.
- W4315778889 hasConcept C126894567 @default.
- W4315778889 hasConcept C134018914 @default.
- W4315778889 hasConcept C164705383 @default.
- W4315778889 hasConcept C2775850156 @default.
- W4315778889 hasConcept C2777955127 @default.
- W4315778889 hasConcept C2778319312 @default.
- W4315778889 hasConcept C2778653478 @default.
- W4315778889 hasConcept C2779918671 @default.
- W4315778889 hasConcept C2780361556 @default.
- W4315778889 hasConcept C2780437262 @default.
- W4315778889 hasConcept C71924100 @default.
- W4315778889 hasConcept C84393581 @default.
- W4315778889 hasConceptScore W4315778889C126322002 @default.
- W4315778889 hasConceptScore W4315778889C126894567 @default.
- W4315778889 hasConceptScore W4315778889C134018914 @default.
- W4315778889 hasConceptScore W4315778889C164705383 @default.
- W4315778889 hasConceptScore W4315778889C2775850156 @default.
- W4315778889 hasConceptScore W4315778889C2777955127 @default.
- W4315778889 hasConceptScore W4315778889C2778319312 @default.
- W4315778889 hasConceptScore W4315778889C2778653478 @default.
- W4315778889 hasConceptScore W4315778889C2779918671 @default.
- W4315778889 hasConceptScore W4315778889C2780361556 @default.
- W4315778889 hasConceptScore W4315778889C2780437262 @default.
- W4315778889 hasConceptScore W4315778889C71924100 @default.
- W4315778889 hasConceptScore W4315778889C84393581 @default.
- W4315778889 hasIssue "Suppl 1" @default.
- W4315778889 hasLocation W43157788891 @default.
- W4315778889 hasLocation W43157788892 @default.
- W4315778889 hasOpenAccess W4315778889 @default.
- W4315778889 hasPrimaryLocation W43157788891 @default.
- W4315778889 hasRelatedWork W1980923625 @default.
- W4315778889 hasRelatedWork W2020930362 @default.
- W4315778889 hasRelatedWork W2043010698 @default.
- W4315778889 hasRelatedWork W2108354142 @default.
- W4315778889 hasRelatedWork W2149464538 @default.
- W4315778889 hasRelatedWork W2159000053 @default.
- W4315778889 hasRelatedWork W2404734884 @default.
- W4315778889 hasRelatedWork W2597715493 @default.
- W4315778889 hasRelatedWork W4239784133 @default.
- W4315778889 hasRelatedWork W4253312407 @default.
- W4315778889 hasVolume "41" @default.
- W4315778889 isParatext "false" @default.
- W4315778889 isRetracted "false" @default.
- W4315778889 workType "article" @default.