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- W4315779420 abstract "Microbial growth in many environments is limited by nitrogen availability, yet there is limited understanding of how complex communities compete for and allocate this resource. Here we develop a broadly applicable approach to track biosynthetic incorporation of 15N-labelled nitrogen substrates into microbial community proteomes, enabling quantification of protein turnover and N allocation to specific cellular functions in individual taxa. Application to oligotrophic ocean surface water identifies taxa-specific substrate preferences and a distinct subset of protein functions undergoing active biosynthesis. The cyanobacterium Prochlorococcus is the most effective competitor for acquisition of ammonium and urea and shifts its proteomic allocation of N over the day/night cycle. Our approach reveals that infrastructure and protein-turnover functions comprise substantial biosynthetic demand for N in Prochlorococcus and a range of other microbial taxa. The direct interrogation of the proteomic underpinnings of N limitation with 15N-tracking proteomics illuminates how nutrient stress differentially influences metabolism in co-existing microbes. Tracking labelled nitrogen atoms from multiple substrates into individual peptides within complex microbial communities shows which cellular functions constitute the bulk of proteomic N demand and the metabolic basis of N limitation." @default.
- W4315779420 created "2023-01-13" @default.
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- W4315779420 date "2023-01-12" @default.
- W4315779420 modified "2023-10-18" @default.
- W4315779420 title "Tracking nitrogen allocation to proteome biosynthesis in a marine microbial community" @default.
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- W4315779420 doi "https://doi.org/10.1038/s41564-022-01303-9" @default.
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