FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315781323> ?p ?o ?g. }

• W4315781323 endingPage "153" @default.
• W4315781323 startingPage "153" @default.
• W4315781323 abstract "Cryptococcus neoformans is the pathogen responsible for cryptococcal pneumonia and meningitis, mainly affecting patients with suppressed immune systems. We have previously revealed the mechanism of anticryptococcal action of synthetic antimicrobial peptides (SAMPs). In this study, computational and experimental analyses provide new insights into the mechanisms of action of SAMPs. Computational analysis revealed that peptides interacted with the PHO36 membrane receptor of C. neoformans. Additionally, ROS (reactive oxygen species) overproduction, the enzymes of ROS metabolism, interference in the ergosterol biosynthesis pathway, and decoupling of cytochrome c mitochondrial membrane were evaluated. Three of four peptides were able to interact with the PHO36 receptor, altering its function and leading to ROS overproduction. SAMPs-treated C. neoformans cells showed a decrease in scavenger enzyme activity, supporting ROS accumulation. In the presence of ascorbic acid, an antioxidant agent, SAMPs did not induce ROS accumulation in C. neoformans cells. Interestingly, two SAMPs maintained inhibitory activity and membrane pore formation in C. neoformans cells by a ROS-independent mechanism. Yet, the ergosterol biosynthesis and lactate dehydrogenase activity were affected by SAMPs. In addition, we noticed decoupling of Cyt c from the mitochondria, which led to apoptosis events in the cryptococcal cells. The results presented herein suggest multiple mechanisms imposed by SAMPs against C. neoformans interfering in the development of resistance, thus revealing the potential of SAMPs in treating infections caused by C. neoformans." @default.
• W4315781323 created "2023-01-13" @default.
• W4315781323 creator A5013489929 @default.
• W4315781323 creator A5027100461 @default.
• W4315781323 creator A5028923131 @default.
• W4315781323 creator A5039349687 @default.
• W4315781323 creator A5050590570 @default.
• W4315781323 creator A5052250955 @default.
• W4315781323 creator A5054618819 @default.
• W4315781323 creator A5064876032 @default.
• W4315781323 creator A5081952253 @default.
• W4315781323 date "2023-01-11" @default.
• W4315781323 modified "2023-10-06" @default.
• W4315781323 title "Behind the Curtain: In Silico and In Vitro Experiments Brought to Light New Insights into the Anticryptococcal Action of Synthetic Peptides" @default.
• W4315781323 cites W1994976851 @default.
• W4315781323 cites W2001055223 @default.
• W4315781323 cites W2025290835 @default.
• W4315781323 cites W2030781488 @default.
• W4315781323 cites W2034969930 @default.
• W4315781323 cites W2049043816 @default.
• W4315781323 cites W2066963700 @default.
• W4315781323 cites W2090419346 @default.
• W4315781323 cites W2120177610 @default.
• W4315781323 cites W2157523243 @default.
• W4315781323 cites W2218476428 @default.
• W4315781323 cites W2552871312 @default.
• W4315781323 cites W2638251159 @default.
• W4315781323 cites W2792135755 @default.
• W4315781323 cites W2904622680 @default.
• W4315781323 cites W2983336787 @default.
• W4315781323 cites W2987400324 @default.
• W4315781323 cites W2991039487 @default.
• W4315781323 cites W3001758718 @default.
• W4315781323 cites W3005781441 @default.
• W4315781323 cites W3035124439 @default.
• W4315781323 cites W3044730196 @default.
• W4315781323 cites W3045684897 @default.
• W4315781323 cites W3097493906 @default.
• W4315781323 cites W3109956990 @default.
• W4315781323 cites W3115824793 @default.
• W4315781323 cites W4200561092 @default.
• W4315781323 cites W4283574985 @default.
• W4315781323 cites W4291892031 @default.
• W4315781323 cites W4304588841 @default.
• W4315781323 cites W4311521631 @default.
• W4315781323 doi "https://doi.org/10.3390/antibiotics12010153" @default.
• W4315781323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36671354" @default.
• W4315781323 hasPublicationYear "2023" @default.
• W4315781323 type Work @default.
• W4315781323 citedByCount "3" @default.
• W4315781323 countsByYear W43157813232023 @default.
• W4315781323 crossrefType "journal-article" @default.
• W4315781323 hasAuthorship W4315781323A5013489929 @default.
• W4315781323 hasAuthorship W4315781323A5027100461 @default.
• W4315781323 hasAuthorship W4315781323A5028923131 @default.
• W4315781323 hasAuthorship W4315781323A5039349687 @default.
• W4315781323 hasAuthorship W4315781323A5050590570 @default.
• W4315781323 hasAuthorship W4315781323A5052250955 @default.
• W4315781323 hasAuthorship W4315781323A5054618819 @default.
• W4315781323 hasAuthorship W4315781323A5064876032 @default.
• W4315781323 hasAuthorship W4315781323A5081952253 @default.
• W4315781323 hasBestOaLocation W43157813231 @default.
• W4315781323 hasConcept C202751555 @default.
• W4315781323 hasConcept C2776120743 @default.
• W4315781323 hasConcept C2777893358 @default.
• W4315781323 hasConcept C2777910421 @default.
• W4315781323 hasConcept C28859421 @default.
• W4315781323 hasConcept C2986274086 @default.
• W4315781323 hasConcept C31903555 @default.
• W4315781323 hasConcept C48349386 @default.
• W4315781323 hasConcept C55493867 @default.
• W4315781323 hasConcept C86803240 @default.
• W4315781323 hasConcept C89423630 @default.
• W4315781323 hasConcept C95444343 @default.
• W4315781323 hasConceptScore W4315781323C202751555 @default.
• W4315781323 hasConceptScore W4315781323C2776120743 @default.
• W4315781323 hasConceptScore W4315781323C2777893358 @default.
• W4315781323 hasConceptScore W4315781323C2777910421 @default.
• W4315781323 hasConceptScore W4315781323C28859421 @default.
• W4315781323 hasConceptScore W4315781323C2986274086 @default.
• W4315781323 hasConceptScore W4315781323C31903555 @default.
• W4315781323 hasConceptScore W4315781323C48349386 @default.
• W4315781323 hasConceptScore W4315781323C55493867 @default.
• W4315781323 hasConceptScore W4315781323C86803240 @default.
• W4315781323 hasConceptScore W4315781323C89423630 @default.
• W4315781323 hasConceptScore W4315781323C95444343 @default.
• W4315781323 hasFunder F4320321091 @default.
• W4315781323 hasIssue "1" @default.
• W4315781323 hasLocation W43157813231 @default.
• W4315781323 hasLocation W43157813232 @default.
• W4315781323 hasLocation W43157813233 @default.
• W4315781323 hasLocation W43157813234 @default.
• W4315781323 hasLocation W43157813235 @default.
• W4315781323 hasOpenAccess W4315781323 @default.
• W4315781323 hasPrimaryLocation W43157813231 @default.
• W4315781323 hasRelatedWork W1882356554 @default.
• W4315781323 hasRelatedWork W1966587121 @default.
• W4315781323 hasRelatedWork W1971639317 @default.

• next