Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315783117> ?p ?o ?g. }
- W4315783117 abstract "Abstract In the vertebrate retina, combinations of Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells by regulating Hes effector gene activity. Owing to reiterated Notch signaling in numerous tissues throughout development, there are multiple vertebrate paralogues for nearly every node in this pathway. These Notch signaling components can act redundantly or in a compensatory fashion during development. To dissect the complexity of this pathway during retinal development, we used seven germline or conditional mutant mice and two spatiotemporally distinct Cre drivers. We perturbed the Notch ternary complex and multiple Hes genes with two overt goals in mind. First, we wished to determine if Notch signaling is required in the optic stalk/nerve head for Hes1 sustained expression and activity. Second, we aimed to test if Hes1, 3 and 5 genes are functionally redundant during early retinal histogenesis. With our allelic series, we found that disrupting Notch signaling consistently blocked mitotic growth and overproduced ganglion cells, but we also identified two significant branchpoints for this pathway. In the optic stalk/nerve head, sustained Hes1 is regulated independent of Notch signaling, whereas during photoreceptor genesis both Notch-dependent and -independent roles for Rbpj and Hes1 impact photoreceptor genesis in opposing manners." @default.
- W4315783117 created "2023-01-13" @default.
- W4315783117 creator A5036037383 @default.
- W4315783117 creator A5054413206 @default.
- W4315783117 creator A5069325928 @default.
- W4315783117 creator A5079558683 @default.
- W4315783117 creator A5089584935 @default.
- W4315783117 date "2023-01-12" @default.
- W4315783117 modified "2023-09-25" @default.
- W4315783117 title "Not all Notch pathway mutations are equal in the embryonic mouse retina" @default.
- W4315783117 cites W1488144685 @default.
- W4315783117 cites W1604956957 @default.
- W4315783117 cites W1890846155 @default.
- W4315783117 cites W1895998181 @default.
- W4315783117 cites W1904460196 @default.
- W4315783117 cites W1960721561 @default.
- W4315783117 cites W1965921684 @default.
- W4315783117 cites W1971636570 @default.
- W4315783117 cites W1973725287 @default.
- W4315783117 cites W1974944966 @default.
- W4315783117 cites W1975358549 @default.
- W4315783117 cites W1976686181 @default.
- W4315783117 cites W1980263460 @default.
- W4315783117 cites W1984425610 @default.
- W4315783117 cites W1987212533 @default.
- W4315783117 cites W1988623932 @default.
- W4315783117 cites W1991954192 @default.
- W4315783117 cites W1992191441 @default.
- W4315783117 cites W1994666066 @default.
- W4315783117 cites W1994750743 @default.
- W4315783117 cites W1994751359 @default.
- W4315783117 cites W1994859370 @default.
- W4315783117 cites W1998766660 @default.
- W4315783117 cites W1999331935 @default.
- W4315783117 cites W2000345957 @default.
- W4315783117 cites W2011341845 @default.
- W4315783117 cites W2015177334 @default.
- W4315783117 cites W2017400430 @default.
- W4315783117 cites W2019705343 @default.
- W4315783117 cites W2021219337 @default.
- W4315783117 cites W2021470827 @default.
- W4315783117 cites W2022133633 @default.
- W4315783117 cites W2026315614 @default.
- W4315783117 cites W2027066480 @default.
- W4315783117 cites W2029559054 @default.
- W4315783117 cites W2037113058 @default.
- W4315783117 cites W2043473335 @default.
- W4315783117 cites W2048389644 @default.
- W4315783117 cites W2050583613 @default.
- W4315783117 cites W2056418457 @default.
- W4315783117 cites W2057550273 @default.
- W4315783117 cites W2059344357 @default.
- W4315783117 cites W2059678501 @default.
- W4315783117 cites W2059840788 @default.
- W4315783117 cites W2060460558 @default.
- W4315783117 cites W2064149590 @default.
- W4315783117 cites W2065510014 @default.
- W4315783117 cites W2066187363 @default.
- W4315783117 cites W2067655070 @default.
- W4315783117 cites W2069036919 @default.
- W4315783117 cites W2071255383 @default.
- W4315783117 cites W2072414883 @default.
- W4315783117 cites W2073366524 @default.
- W4315783117 cites W2078284356 @default.
- W4315783117 cites W2080832893 @default.
- W4315783117 cites W2086059239 @default.
- W4315783117 cites W2088901973 @default.
- W4315783117 cites W2088969512 @default.
- W4315783117 cites W2094457561 @default.
- W4315783117 cites W2095397411 @default.
- W4315783117 cites W2095666604 @default.
- W4315783117 cites W2098272219 @default.
- W4315783117 cites W2101728847 @default.
- W4315783117 cites W2102406841 @default.
- W4315783117 cites W2114923998 @default.
- W4315783117 cites W2116140011 @default.
- W4315783117 cites W2116354730 @default.
- W4315783117 cites W2117193130 @default.
- W4315783117 cites W2117383884 @default.
- W4315783117 cites W2125509137 @default.
- W4315783117 cites W2125842849 @default.
- W4315783117 cites W2128863223 @default.
- W4315783117 cites W2129618668 @default.
- W4315783117 cites W2131137929 @default.
- W4315783117 cites W2136899592 @default.
- W4315783117 cites W2138903858 @default.
- W4315783117 cites W2145297890 @default.
- W4315783117 cites W2148590737 @default.
- W4315783117 cites W2149557024 @default.
- W4315783117 cites W2152244674 @default.
- W4315783117 cites W2155553885 @default.
- W4315783117 cites W2157862682 @default.
- W4315783117 cites W2163517157 @default.
- W4315783117 cites W2167546055 @default.
- W4315783117 cites W2169250880 @default.
- W4315783117 cites W2267772868 @default.
- W4315783117 cites W2294272112 @default.
- W4315783117 cites W2325027671 @default.
- W4315783117 cites W2397703300 @default.
- W4315783117 cites W2414258062 @default.