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- W4315784877 abstract "Cancer immunotherapy critically depends on fitness of cytotoxic and helper T cell responses. Dysfunctional cytotoxic T cell states in the tumor microenvironment (TME) are a major cause of resistance to immunotherapy. Intratumoral myeloid cells, particularly blood-borne myeloids (bbm), are key drivers of T cell dysfunction in the TME. We show here that major histocompatibility complex class II (MHCII)-restricted antigen presentation on bbm is essential to control the growth of brain tumors. Loss of MHCII on bbm drives dysfunctional intratumoral tumor-reactive CD8+ T cell states through increased chromatin accessibility and expression of Tox, a critical regulator of T cell exhaustion. Mechanistically, MHCII-dependent activation of CD4+ T cells restricts myeloid-derived osteopontin that triggers a chronic activation of NFAT2 in tumor-reactive CD8+ T cells. In summary, we provide evidence that MHCII-restricted antigen presentation on bbm is a key mechanism to directly maintain functional cytotoxic T cell states in brain tumors." @default.
- W4315784877 created "2023-01-13" @default.
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- W4315784877 date "2023-02-01" @default.
- W4315784877 modified "2023-10-16" @default.
- W4315784877 title "MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors" @default.
- W4315784877 cites W1506672302 @default.
- W4315784877 cites W1910012553 @default.
- W4315784877 cites W1971620413 @default.
- W4315784877 cites W1980485314 @default.
- W4315784877 cites W1984611249 @default.
- W4315784877 cites W1991839416 @default.
- W4315784877 cites W2011458181 @default.
- W4315784877 cites W2019604999 @default.
- W4315784877 cites W2025381786 @default.
- W4315784877 cites W2027230614 @default.
- W4315784877 cites W2037628050 @default.
- W4315784877 cites W2060070314 @default.
- W4315784877 cites W2066671159 @default.
- W4315784877 cites W2079696222 @default.
- W4315784877 cites W2135712656 @default.
- W4315784877 cites W2154614014 @default.
- W4315784877 cites W2190672185 @default.
- W4315784877 cites W2219506342 @default.
- W4315784877 cites W2220215167 @default.
- W4315784877 cites W2264544376 @default.
- W4315784877 cites W2267280007 @default.
- W4315784877 cites W2342423058 @default.
- W4315784877 cites W2506616866 @default.
- W4315784877 cites W2510606169 @default.
- W4315784877 cites W2541023789 @default.
- W4315784877 cites W2541574334 @default.
- W4315784877 cites W2578528809 @default.
- W4315784877 cites W2595863515 @default.
- W4315784877 cites W2616155686 @default.
- W4315784877 cites W2617597517 @default.
- W4315784877 cites W2738946651 @default.
- W4315784877 cites W2749747068 @default.
- W4315784877 cites W2765199703 @default.
- W4315784877 cites W2767624281 @default.
- W4315784877 cites W2791483720 @default.
- W4315784877 cites W2797429263 @default.
- W4315784877 cites W2808421749 @default.
- W4315784877 cites W2878436114 @default.
- W4315784877 cites W2884754721 @default.
- W4315784877 cites W2896996016 @default.
- W4315784877 cites W2898701133 @default.
- W4315784877 cites W2899145148 @default.
- W4315784877 cites W2904210127 @default.
- W4315784877 cites W2904803926 @default.
- W4315784877 cites W2907549567 @default.
- W4315784877 cites W2908581980 @default.
- W4315784877 cites W2909486828 @default.
- W4315784877 cites W2911752971 @default.
- W4315784877 cites W2911871569 @default.
- W4315784877 cites W2913558101 @default.
- W4315784877 cites W2913623258 @default.
- W4315784877 cites W2932352133 @default.
- W4315784877 cites W2946657092 @default.
- W4315784877 cites W2951598503 @default.
- W4315784877 cites W2952815301 @default.
- W4315784877 cites W2982049472 @default.
- W4315784877 cites W2994237727 @default.
- W4315784877 cites W2994331021 @default.
- W4315784877 cites W2994938720 @default.
- W4315784877 cites W3005326482 @default.
- W4315784877 cites W3007007406 @default.
- W4315784877 cites W3012344676 @default.
- W4315784877 cites W3028523516 @default.
- W4315784877 cites W3030339055 @default.
- W4315784877 cites W3032465961 @default.
- W4315784877 cites W3048641542 @default.
- W4315784877 cites W3131460561 @default.
- W4315784877 cites W3137406939 @default.
- W4315784877 cites W3165476047 @default.
- W4315784877 cites W3179304282 @default.
- W4315784877 cites W3181404157 @default.
- W4315784877 cites W3193419934 @default.