Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315796453> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4315796453 endingPage "33" @default.
- W4315796453 startingPage "28" @default.
- W4315796453 abstract "BACKGROUND: Bedaquiline (BDQ) as a fumarate salt is indicated as part of a regimen to treat multidrug-resistant TB (MDR-TB). BDQ benzoate and maleate have been identified as promising alternatives that will encourage generic pharmaceutical houses to manufacture this drug. Our study compared the pharmacokinetics (PK) of BDQ fumarate vs. the maleate and benzoate salts in dogs.METHODS: The PK of BDQ and its active N-desmethyl metabolite M2 following intravenous administration of 1 mg/kg BDQ (as fumarate) and oral administration of 10 mg/kg BDQ as fumarate, benzoate, or maleate salts in suspension to fasted male beagle dogs was evaluated in a parallel-group and crossover study with N = 4 per group. BDQ and M2 plasma concentrations were determined up to 168 h post-dose. T-tests were conducted to compare the area under the curve, AUC0-t among groups.RESULTS: Orally administered fumarate, benzoate, and maleate salts, in parallel-group design, resulted in mean BDQ AUC0-t of 9,267 ± SD 10,182, 19,258 ± SD 11,803, and 15,396 ± SD 9,170 ng.h/ml, respectively; and in a crossover design of 9,267 ± SD 10,182, 17,441 ± SD 24,049, and 18,087 ± SD 19,758 ng.h/ml, respectively. P values were >0.05.CONCLUSION: There was no statistically significant difference in BDQ and M2 AUC0-t following oral administration of fumarate, benzoate and maleate salts in dogs." @default.
- W4315796453 created "2023-01-13" @default.
- W4315796453 creator A5005576452 @default.
- W4315796453 creator A5019483811 @default.
- W4315796453 creator A5026034648 @default.
- W4315796453 creator A5055158035 @default.
- W4315796453 creator A5090696000 @default.
- W4315796453 date "2023-01-01" @default.
- W4315796453 modified "2023-10-14" @default.
- W4315796453 title "Comparison of pharmacokinetics and bioavailability of bedaquiline fumarate, benzoate and maleate in dogs" @default.
- W4315796453 cites W3093967985 @default.
- W4315796453 cites W3144581627 @default.
- W4315796453 cites W3194237592 @default.
- W4315796453 doi "https://doi.org/10.5588/ijtld.22.0326" @default.
- W4315796453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36853125" @default.
- W4315796453 hasPublicationYear "2023" @default.
- W4315796453 type Work @default.
- W4315796453 citedByCount "0" @default.
- W4315796453 crossrefType "journal-article" @default.
- W4315796453 hasAuthorship W4315796453A5005576452 @default.
- W4315796453 hasAuthorship W4315796453A5019483811 @default.
- W4315796453 hasAuthorship W4315796453A5026034648 @default.
- W4315796453 hasAuthorship W4315796453A5055158035 @default.
- W4315796453 hasAuthorship W4315796453A5090696000 @default.
- W4315796453 hasBestOaLocation W43157964531 @default.
- W4315796453 hasConcept C112705442 @default.
- W4315796453 hasConcept C126322002 @default.
- W4315796453 hasConcept C142724271 @default.
- W4315796453 hasConcept C149151106 @default.
- W4315796453 hasConcept C181389837 @default.
- W4315796453 hasConcept C204787440 @default.
- W4315796453 hasConcept C27081682 @default.
- W4315796453 hasConcept C2776820430 @default.
- W4315796453 hasConcept C2777056448 @default.
- W4315796453 hasConcept C2777477808 @default.
- W4315796453 hasConcept C71924100 @default.
- W4315796453 hasConcept C87813604 @default.
- W4315796453 hasConcept C98274493 @default.
- W4315796453 hasConceptScore W4315796453C112705442 @default.
- W4315796453 hasConceptScore W4315796453C126322002 @default.
- W4315796453 hasConceptScore W4315796453C142724271 @default.
- W4315796453 hasConceptScore W4315796453C149151106 @default.
- W4315796453 hasConceptScore W4315796453C181389837 @default.
- W4315796453 hasConceptScore W4315796453C204787440 @default.
- W4315796453 hasConceptScore W4315796453C27081682 @default.
- W4315796453 hasConceptScore W4315796453C2776820430 @default.
- W4315796453 hasConceptScore W4315796453C2777056448 @default.
- W4315796453 hasConceptScore W4315796453C2777477808 @default.
- W4315796453 hasConceptScore W4315796453C71924100 @default.
- W4315796453 hasConceptScore W4315796453C87813604 @default.
- W4315796453 hasConceptScore W4315796453C98274493 @default.
- W4315796453 hasIssue "1" @default.
- W4315796453 hasLocation W43157964531 @default.
- W4315796453 hasLocation W43157964532 @default.
- W4315796453 hasLocation W43157964533 @default.
- W4315796453 hasOpenAccess W4315796453 @default.
- W4315796453 hasPrimaryLocation W43157964531 @default.
- W4315796453 hasRelatedWork W1937556892 @default.
- W4315796453 hasRelatedWork W1965365122 @default.
- W4315796453 hasRelatedWork W1977686717 @default.
- W4315796453 hasRelatedWork W1984317973 @default.
- W4315796453 hasRelatedWork W1998356222 @default.
- W4315796453 hasRelatedWork W2040155790 @default.
- W4315796453 hasRelatedWork W2040224589 @default.
- W4315796453 hasRelatedWork W2056938528 @default.
- W4315796453 hasRelatedWork W2331297863 @default.
- W4315796453 hasRelatedWork W2621131398 @default.
- W4315796453 hasVolume "27" @default.
- W4315796453 isParatext "false" @default.
- W4315796453 isRetracted "false" @default.
- W4315796453 workType "article" @default.