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- W4315796819 abstract "The hypothalamic neuroendocrine catecholamine dopamine regulates the lactotroph function, including prolactin (PRL) secretion, proliferation, and apoptosis. The treatment of PRL-secreting tumors, formerly known as prolactinomas, has relied mainly on this physiological characteristic, making dopamine agonists the first therapeutic alternative. Nevertheless, the group of patients that do not respond to this treatment has few therapeutical options. Prolactin is another physiological regulator of lactotroph function, acting as an autocrine/paracrine factor that controls PRL secretion and cellular turnover, inducing apoptosis and decreasing proliferation. Furthermore, the signaling pathways related to these effects, mainly JAK/STAT and PI3K/Akt, and MAPK, have been extensively studied in prolactinomas and other tumors as therapeutic targets. In the present work, the relationship between PRL pathophysiology and prolactinoma development is explored, aiming to comprehend the value of PRL and PRLR-associated pathways as exploratory fields alternative to dopamine-related approaches, which are worth physiological characteristics that might be impaired and can be potentially restored or upregulated to provide more options to the patients." @default.
- W4315796819 created "2023-01-13" @default.
- W4315796819 creator A5044111653 @default.
- W4315796819 date "2023-01-12" @default.
- W4315796819 modified "2023-10-14" @default.
- W4315796819 title "Is prolactin receptor signaling a target in dopamine-resistant prolactinomas?" @default.
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- W4315796819 cites W1991106585 @default.
- W4315796819 cites W1992712789 @default.
- W4315796819 cites W1994056701 @default.
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- W4315796819 cites W2035141753 @default.
- W4315796819 cites W2038348668 @default.
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- W4315796819 doi "https://doi.org/10.3389/fendo.2022.1057749" @default.
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- W4315796819 hasPublicationYear "2023" @default.
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