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• W4315866616 abstract "BACKGROUND: The present retrospective study aimed to measure the validity of the new iRECIST criteria compared to the traditional RECIST1.1 in the context of evaluating the response of advanced non-small cell lung cancer (NSCLC) to immunotherapy treatment with PD-1 inhibitors.METHODS: In the period between December 2019 and December 2020, at the U.O.S. of Oncology and the U.O.S.V.D. of Radiodiagnostics of the F. Veneziale Hospital in Isernia, the medical records of 15 patients affected by advanced stage NSCLC lung cancer, all under immunotherapy treatment with PD-1 inhibitors (nivolumab or pembrolizumab) were retrospectively analyzed. Pregnant patients with known allergy to contrast media were excluded. All patients underwent CT without and with contrast medium iodate of skull, thorax and abdomen in staging phase and in four control intervals during treatment.RESULTS: In the four-time intervals the two radiological evaluation systems showed a different evaluation for 40%, 67%, 67% and 35% of patients respectively, judged in progression by RECIST1.1 but deserving of re-evaluation according to iRECIST. The remote control revealed a false progression of the disease in 30% of the patients who benefited from the continuation of the therapy.CONCLUSIONS: Our study confirmed what the literature proposes regarding the management of patients treated with immunotherapy, especially through the use of the iRECIST criteria. In particular, the mechanism of pseudoprogression has sanctioned the importance of the iRECIST criteria which resulted superior because they embody the rationale and the biological assumptions related to the immune response mechanism which provides for the massive recall of cytotoxic T lymphocytes within the neoplastic mass with an initial increase of the same and with subsequent reduction of the tumor volume following the therapeutic effect. Therefore, the iRECIST criteria constitute an optimal method of radiological evaluation in the management of the cancer patient affected by NSCLC, not only because they are able to reliably establish the type of response found in each patient but also because they demonstrate the identification of those cases in which an apparent initial increase of the tumor load, evaluated as true progression by RECIST1.1, would lead to the interruption of the immunotherapy treatment, losing the important benefits it entails." @default.
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• W4315866616 date "2023-01-01" @default.
• W4315866616 modified "2023-10-16" @default.
• W4315866616 title "Radiological response criteria in non-small cell lung cancer treated with immunotherapy: RECIST1.1 vs. iRECIST" @default.
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• W4315866616 doi "https://doi.org/10.23736/s2723-9284.22.00215-1" @default.
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