Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315928348> ?p ?o ?g. }
- W4315928348 endingPage "402" @default.
- W4315928348 startingPage "388" @default.
- W4315928348 abstract "The authors tested the hypothesis that the effects of traumatic brain injury, surgery, and sevoflurane interact to induce neurobehavioral abnormalities in adult male rats and in their offspring (an animal model of intergenerational perioperative neurocognitive disorder).Sprague-Dawley male rats (assigned generation F0) underwent a traumatic brain injury on postnatal day 60 that involved craniectomy (surgery) under 3% sevoflurane for 40 min followed by 2.1% sevoflurane for 3 h on postnatal days 62, 64, and 66 (injury group). The surgery group had craniectomy without traumatic brain injury, whereas the sevoflurane group had sevoflurane only. On postnatal day 90, F0 males and control females were mated to generate offspring (assigned generation F1).Acutely, F0 injury rats exhibited the greatest increases in serum corticosterone and interleukin-1β and -6, and activation of the hippocampal microglia. Long-term, compared to controls, F0 injury rats had the most exacerbated corticosterone levels at rest (mean ± SD, 2.21 ± 0.64 vs. 7.28 ± 1.95 ng/ml, n = 7 - 8; P < 0.001) and 10 min after restraint (133.12 ± 33.98 vs. 232.83 ± 40.71 ng/ml, n = 7 - 8; P < 0.001), increased interleukin-1β and -6, and reduced expression of hippocampal glucocorticoid receptor (Nr3c1; 0.53 ± 0.08 fold change relative to control, P < 0.001, n = 6) and brain-derived neurotrophic factor genes. They also exhibited greater behavioral deficiencies. Similar abnormalities were evident in their male offspring, whereas F1 females were not affected. The reduced Nr3c1 expression in F1 male, but not female, hippocampus was accompanied by corresponding Nr3c1 promoter hypermethylated CpG sites in F0 spermatozoa and F1 male, but not female, hippocampus.These findings in rats suggest that young adult males with traumatic brain injury are at an increased risk of developing perioperative neurocognitive disorder, as are their unexposed male but not female offspring." @default.
- W4315928348 created "2023-01-14" @default.
- W4315928348 creator A5013666609 @default.
- W4315928348 creator A5031379605 @default.
- W4315928348 creator A5033290141 @default.
- W4315928348 creator A5045000539 @default.
- W4315928348 creator A5055142389 @default.
- W4315928348 creator A5061497844 @default.
- W4315928348 creator A5073155596 @default.
- W4315928348 creator A5083367027 @default.
- W4315928348 creator A5084873040 @default.
- W4315928348 date "2023-01-13" @default.
- W4315928348 modified "2023-10-18" @default.
- W4315928348 title "Intergenerational Perioperative Neurocognitive Disorder in Young Adult Male Rats with Traumatic Brain Injury" @default.
- W4315928348 cites W1878005343 @default.
- W4315928348 cites W1973260699 @default.
- W4315928348 cites W2049069390 @default.
- W4315928348 cites W2127720026 @default.
- W4315928348 cites W2137209519 @default.
- W4315928348 cites W2137368645 @default.
- W4315928348 cites W2139463883 @default.
- W4315928348 cites W2149615621 @default.
- W4315928348 cites W2152997475 @default.
- W4315928348 cites W2287198619 @default.
- W4315928348 cites W2301018241 @default.
- W4315928348 cites W2345460154 @default.
- W4315928348 cites W2443212980 @default.
- W4315928348 cites W2592627264 @default.
- W4315928348 cites W2624385086 @default.
- W4315928348 cites W2699395010 @default.
- W4315928348 cites W2761465119 @default.
- W4315928348 cites W2762795592 @default.
- W4315928348 cites W2766132918 @default.
- W4315928348 cites W2767813783 @default.
- W4315928348 cites W2806289196 @default.
- W4315928348 cites W2883381857 @default.
- W4315928348 cites W2888450536 @default.
- W4315928348 cites W2896112251 @default.
- W4315928348 cites W2904308212 @default.
- W4315928348 cites W2915157760 @default.
- W4315928348 cites W2946764402 @default.
- W4315928348 cites W2971246511 @default.
- W4315928348 cites W2972323603 @default.
- W4315928348 cites W2973134157 @default.
- W4315928348 cites W2990542775 @default.
- W4315928348 cites W2990690468 @default.
- W4315928348 cites W3011484207 @default.
- W4315928348 cites W3089740659 @default.
- W4315928348 cites W3093962574 @default.
- W4315928348 cites W3109327837 @default.
- W4315928348 cites W3113705801 @default.
- W4315928348 cites W3127059571 @default.
- W4315928348 cites W3132330262 @default.
- W4315928348 cites W3163329434 @default.
- W4315928348 cites W3175681906 @default.
- W4315928348 cites W4220807859 @default.
- W4315928348 cites W4282918976 @default.
- W4315928348 cites W4296816736 @default.
- W4315928348 doi "https://doi.org/10.1097/aln.0000000000004496" @default.
- W4315928348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36637480" @default.
- W4315928348 hasPublicationYear "2023" @default.
- W4315928348 type Work @default.
- W4315928348 citedByCount "1" @default.
- W4315928348 countsByYear W43159283482023 @default.
- W4315928348 crossrefType "journal-article" @default.
- W4315928348 hasAuthorship W4315928348A5013666609 @default.
- W4315928348 hasAuthorship W4315928348A5031379605 @default.
- W4315928348 hasAuthorship W4315928348A5033290141 @default.
- W4315928348 hasAuthorship W4315928348A5045000539 @default.
- W4315928348 hasAuthorship W4315928348A5055142389 @default.
- W4315928348 hasAuthorship W4315928348A5061497844 @default.
- W4315928348 hasAuthorship W4315928348A5073155596 @default.
- W4315928348 hasAuthorship W4315928348A5083367027 @default.
- W4315928348 hasAuthorship W4315928348A5084873040 @default.
- W4315928348 hasConcept C112672928 @default.
- W4315928348 hasConcept C118552586 @default.
- W4315928348 hasConcept C126322002 @default.
- W4315928348 hasConcept C134018914 @default.
- W4315928348 hasConcept C142724271 @default.
- W4315928348 hasConcept C148762608 @default.
- W4315928348 hasConcept C169900460 @default.
- W4315928348 hasConcept C172467417 @default.
- W4315928348 hasConcept C204787440 @default.
- W4315928348 hasConcept C2775961468 @default.
- W4315928348 hasConcept C2779234561 @default.
- W4315928348 hasConcept C2780352252 @default.
- W4315928348 hasConcept C2780841215 @default.
- W4315928348 hasConcept C2781017439 @default.
- W4315928348 hasConcept C2781161787 @default.
- W4315928348 hasConcept C2781453256 @default.
- W4315928348 hasConcept C31174226 @default.
- W4315928348 hasConcept C42219234 @default.
- W4315928348 hasConcept C54355233 @default.
- W4315928348 hasConcept C71315377 @default.
- W4315928348 hasConcept C71924100 @default.
- W4315928348 hasConcept C86803240 @default.
- W4315928348 hasConceptScore W4315928348C112672928 @default.
- W4315928348 hasConceptScore W4315928348C118552586 @default.