FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4315979085> ?p ?o ?g. }

• W4315979085 endingPage "67" @default.
• W4315979085 startingPage "55" @default.
• W4315979085 abstract "Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to study the dynamics of biomolecules in solution. Most NMR studies exploit the spins of proton, carbon and nitrogen isotopes, as these atoms are highly abundant in proteins and nucleic acids. As an alternative and complementary approach, fluorine atoms can be introduced into biomolecules at specific sites of interest. These labels can then be used as sensitive probes for biomolecular structure, dynamics or interactions. Here, we address if the replacement of tryptophan with 5-fluorotryptophan residues has an effect on the overall dynamics of proteins and if the introduced fluorine probe is able to accurately report on global exchange processes. For the four different model proteins (KIX, Dcp1, Dcp2 and DcpS) that we examined, we established that 15N CPMG relaxation dispersion or EXSY profiles are not affected by the 5-fluorotryptophan, indicating that this replacement of a proton with a fluorine has no effect on the protein motions. However, we found that the motions that the 5-fluorotryptophan reports on can be significantly faster than the backbone motions. This implies that care needs to be taken when interpreting fluorine relaxation data in terms of global protein motions. In summary, our results underscore the great potential of fluorine NMR methods, but also highlight potential pitfalls that need to be considered." @default.
• W4315979085 created "2023-01-14" @default.
• W4315979085 creator A5047709630 @default.
• W4315979085 creator A5051714306 @default.
• W4315979085 date "2023-01-14" @default.
• W4315979085 modified "2023-10-16" @default.
• W4315979085 title "Assessing the applicability of 19F labeled tryptophan residues to quantify protein dynamics" @default.
• W4315979085 cites W1181555117 @default.
• W4315979085 cites W1553966517 @default.
• W4315979085 cites W1967172732 @default.
• W4315979085 cites W1969987257 @default.
• W4315979085 cites W1977672277 @default.
• W4315979085 cites W1991329325 @default.
• W4315979085 cites W1994561292 @default.
• W4315979085 cites W1997291282 @default.
• W4315979085 cites W1997358511 @default.
• W4315979085 cites W2003915076 @default.
• W4315979085 cites W2014349449 @default.
• W4315979085 cites W2020356593 @default.
• W4315979085 cites W2022539009 @default.
• W4315979085 cites W2022931660 @default.
• W4315979085 cites W2026765676 @default.
• W4315979085 cites W2033058885 @default.
• W4315979085 cites W2039241525 @default.
• W4315979085 cites W2048822589 @default.
• W4315979085 cites W2053549636 @default.
• W4315979085 cites W2053724582 @default.
• W4315979085 cites W2053867269 @default.
• W4315979085 cites W2054191418 @default.
• W4315979085 cites W2056667908 @default.
• W4315979085 cites W2066036121 @default.
• W4315979085 cites W2070354036 @default.
• W4315979085 cites W2074856155 @default.
• W4315979085 cites W2075731957 @default.
• W4315979085 cites W2084038555 @default.
• W4315979085 cites W2084295374 @default.
• W4315979085 cites W2090318167 @default.
• W4315979085 cites W2096229719 @default.
• W4315979085 cites W2102459914 @default.
• W4315979085 cites W2104938413 @default.
• W4315979085 cites W2105032120 @default.
• W4315979085 cites W2111471835 @default.
• W4315979085 cites W2114918981 @default.
• W4315979085 cites W2117815641 @default.
• W4315979085 cites W2120817777 @default.
• W4315979085 cites W2124756763 @default.
• W4315979085 cites W2165980400 @default.
• W4315979085 cites W2169821755 @default.
• W4315979085 cites W2171531038 @default.
• W4315979085 cites W2280868245 @default.
• W4315979085 cites W2318062538 @default.
• W4315979085 cites W2343092299 @default.
• W4315979085 cites W2408804828 @default.
• W4315979085 cites W2475355234 @default.
• W4315979085 cites W2597024964 @default.
• W4315979085 cites W2620221124 @default.
• W4315979085 cites W2785534246 @default.
• W4315979085 cites W2969570045 @default.
• W4315979085 cites W2970789810 @default.
• W4315979085 cites W2978977982 @default.
• W4315979085 cites W2991471489 @default.
• W4315979085 cites W3003635251 @default.
• W4315979085 cites W3003759715 @default.
• W4315979085 cites W3006049638 @default.
• W4315979085 cites W3021242647 @default.
• W4315979085 cites W3028008645 @default.
• W4315979085 cites W3045619975 @default.
• W4315979085 cites W3090257342 @default.
• W4315979085 cites W3128777856 @default.
• W4315979085 cites W3162500209 @default.
• W4315979085 cites W4200489509 @default.
• W4315979085 cites W4205833971 @default.
• W4315979085 cites W4224085737 @default.
• W4315979085 cites W4293237483 @default.
• W4315979085 doi "https://doi.org/10.1007/s10858-022-00411-2" @default.
• W4315979085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36639431" @default.
• W4315979085 hasPublicationYear "2023" @default.
• W4315979085 type Work @default.
• W4315979085 citedByCount "2" @default.
• W4315979085 countsByYear W43159790852023 @default.
• W4315979085 crossrefType "journal-article" @default.
• W4315979085 hasAuthorship W4315979085A5047709630 @default.
• W4315979085 hasAuthorship W4315979085A5051714306 @default.
• W4315979085 hasBestOaLocation W43159790851 @default.
• W4315979085 hasConcept C116447816 @default.
• W4315979085 hasConcept C120665830 @default.
• W4315979085 hasConcept C121332964 @default.
• W4315979085 hasConcept C147597530 @default.
• W4315979085 hasConcept C15744967 @default.
• W4315979085 hasConcept C159467904 @default.
• W4315979085 hasConcept C177562468 @default.
• W4315979085 hasConcept C178790620 @default.
• W4315979085 hasConcept C185592680 @default.
• W4315979085 hasConcept C204389451 @default.
• W4315979085 hasConcept C26873012 @default.
• W4315979085 hasConcept C2775981520 @default.
• W4315979085 hasConcept C2776029896 @default.
• W4315979085 hasConcept C2778870898 @default.

• next