Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316015921> ?p ?o ?g. }
- W4316015921 abstract "Abstract Tumor-associated macrophages (TAMs) account for 30–50% of glioma microenvironment. The interaction between glioma tumor cells and TAMs can promote tumor progression, but the intrinsic mechanisms remain unclear. Herein, we reported that soluble LRIG3 (sLRIG3) derived from glioma tumor cells can block the M2 polarization of TAMs via interacting with NETO2, thus suppressing GBM malignant progression. The expression or activity of ADAM17 in glioma cells was positively correlated with the expression of sLRIG3 in cell supernatant. Soluble LRIG3 can suppress the M2-like polarity transformation of TAMs and inhibit the growth of tumor. High expression of LRIG3 predicts a good prognosis in patients with glioma. Mass spectrometry and Co-immunoprecipitation showed that sLRIG3 interacts with the CUB1 domain of NETO2 in TAMs. Silencing or knockout of NETO2 could block the effect of sLRIG3, which inhibited the M2-like polarity transformation of TAMs and promoted GBM tumor growth. However, overexpressing His-target NETO2 with CUB1 deletion mutation does not fully recover the suppressive effects of sLRIG3 on the TAM M2-polarization in NETO2-Knockout TAMs. Our study revealed vital molecular crosstalk between GBM tumor cells and TAMs. Glioma cells mediated the M2 polarization of TAM through the sLRIG3-NETO2 pathway and inhibited the progression of GBM, suggesting that sLRIG3-NETO2 may be a potential target for GBM treatment." @default.
- W4316015921 created "2023-01-14" @default.
- W4316015921 creator A5017085245 @default.
- W4316015921 creator A5025623657 @default.
- W4316015921 creator A5034031259 @default.
- W4316015921 creator A5041747958 @default.
- W4316015921 creator A5046597133 @default.
- W4316015921 creator A5048887247 @default.
- W4316015921 creator A5074564038 @default.
- W4316015921 creator A5074608828 @default.
- W4316015921 creator A5083494977 @default.
- W4316015921 creator A5089572992 @default.
- W4316015921 date "2023-01-13" @default.
- W4316015921 modified "2023-10-08" @default.
- W4316015921 title "Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth" @default.
- W4316015921 cites W1972476556 @default.
- W4316015921 cites W1980485314 @default.
- W4316015921 cites W1997269229 @default.
- W4316015921 cites W1997543074 @default.
- W4316015921 cites W2032128230 @default.
- W4316015921 cites W2044200527 @default.
- W4316015921 cites W2073586533 @default.
- W4316015921 cites W2082337923 @default.
- W4316015921 cites W2105164395 @default.
- W4316015921 cites W2124462800 @default.
- W4316015921 cites W2125521995 @default.
- W4316015921 cites W2130410032 @default.
- W4316015921 cites W2130430382 @default.
- W4316015921 cites W2148977460 @default.
- W4316015921 cites W2149441684 @default.
- W4316015921 cites W2220215167 @default.
- W4316015921 cites W2529484692 @default.
- W4316015921 cites W2595863515 @default.
- W4316015921 cites W2620943949 @default.
- W4316015921 cites W2740090202 @default.
- W4316015921 cites W2749747068 @default.
- W4316015921 cites W2774491730 @default.
- W4316015921 cites W2781008432 @default.
- W4316015921 cites W2791477629 @default.
- W4316015921 cites W2794101039 @default.
- W4316015921 cites W2799441834 @default.
- W4316015921 cites W2803225762 @default.
- W4316015921 cites W2803758687 @default.
- W4316015921 cites W2896996016 @default.
- W4316015921 cites W2903400169 @default.
- W4316015921 cites W2905406250 @default.
- W4316015921 cites W2912485591 @default.
- W4316015921 cites W2913538305 @default.
- W4316015921 cites W2917960773 @default.
- W4316015921 cites W2948097715 @default.
- W4316015921 cites W2948223670 @default.
- W4316015921 cites W2948808148 @default.
- W4316015921 cites W2971006194 @default.
- W4316015921 cites W2973085389 @default.
- W4316015921 cites W2974646711 @default.
- W4316015921 cites W3001063544 @default.
- W4316015921 cites W3009898868 @default.
- W4316015921 cites W3011299571 @default.
- W4316015921 cites W3015150584 @default.
- W4316015921 cites W3026551532 @default.
- W4316015921 cites W3030339055 @default.
- W4316015921 cites W3033869535 @default.
- W4316015921 cites W3089667275 @default.
- W4316015921 cites W3096267580 @default.
- W4316015921 cites W3106806530 @default.
- W4316015921 cites W3132155386 @default.
- W4316015921 cites W3155578658 @default.
- W4316015921 cites W3165863602 @default.
- W4316015921 cites W3193555135 @default.
- W4316015921 cites W4211132876 @default.
- W4316015921 cites W4220964199 @default.
- W4316015921 cites W4295512949 @default.
- W4316015921 cites W574602253 @default.
- W4316015921 doi "https://doi.org/10.1038/s41419-023-05555-z" @default.
- W4316015921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36639372" @default.
- W4316015921 hasPublicationYear "2023" @default.
- W4316015921 type Work @default.
- W4316015921 citedByCount "1" @default.
- W4316015921 countsByYear W43160159212023 @default.
- W4316015921 crossrefType "journal-article" @default.
- W4316015921 hasAuthorship W4316015921A5017085245 @default.
- W4316015921 hasAuthorship W4316015921A5025623657 @default.
- W4316015921 hasAuthorship W4316015921A5034031259 @default.
- W4316015921 hasAuthorship W4316015921A5041747958 @default.
- W4316015921 hasAuthorship W4316015921A5046597133 @default.
- W4316015921 hasAuthorship W4316015921A5048887247 @default.
- W4316015921 hasAuthorship W4316015921A5074564038 @default.
- W4316015921 hasAuthorship W4316015921A5074608828 @default.
- W4316015921 hasAuthorship W4316015921A5083494977 @default.
- W4316015921 hasAuthorship W4316015921A5089572992 @default.
- W4316015921 hasBestOaLocation W43160159211 @default.
- W4316015921 hasConcept C104317684 @default.
- W4316015921 hasConcept C119056186 @default.
- W4316015921 hasConcept C120665830 @default.
- W4316015921 hasConcept C121332964 @default.
- W4316015921 hasConcept C169822122 @default.
- W4316015921 hasConcept C170493617 @default.
- W4316015921 hasConcept C182704531 @default.
- W4316015921 hasConcept C185592680 @default.
- W4316015921 hasConcept C2776107976 @default.