Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316077499> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4316077499 endingPage "e1768" @default.
- W4316077499 startingPage "e1768" @default.
- W4316077499 abstract "Introduction: Radiation induced gastritis is an uncommon complication of radiation therapy. Therapies that have been attempted for this pathology include argon plasma coagulation (APC), oral prednisolone, radio-frequency ablation, hyperbaric oxygen, and surgical intervention. We present a case of radiation induced gastritis complicated by transfusion dependent anemia and melena that was successfully treated with Bevacizumab Case Description/Methods: This patient is a 65-year-old male with medical history significant for esophageal adenocarcinoma in 2014 treated with chemoradiation and subsequently esophagectomy. Several years after therapy, he started to report tarry stools, and was found to be anemic with iron studies consistent with severe iron deficiency. He had an esophagogastroduodenoscopy (EGD) that showed severe distal esophagitis. Follow up colonoscopy was unremarkable. He was started on omeprazole and iron infusions, but he needed frequent blood transfusions. He had a repeat EGD that showed diffuse erythema, friability and oozing of the gastric mucosa. This was treated with APC. A biopsy showed a single focus of intravascular fibrin thrombus concerning for radiation induced gastritis. He had transient resolution of his melena, but then had recurrence one month later. He underwent further endoscopies with thermal therapy, which failed to control his bleeding. Hyperbaric oxygen therapy was trialed. After completing multiple sessions, his symptoms persisted. Surgical evaluation was recommended but the patient declined. The patient was then started on anti-angiogenic therapy with Bevacizumab 5mg/kg every 2 weeks and his melena resolved, requiring less transfusions. He stopped taking Bevacizumab two months later as he was scheduled for hernia repair, and he had recurrence of his melena and worsening anemia post-operatively. After being restarted on Bevacizumab, his melena resolved Discussion: Hemorrhagic radiation gastritis is mainly due to mucosal injury and telangiectatic vessels from angiogenesis secondary to endothelial proliferation. Bevacizumab is an anti-vascular endothelial growth factor humanized monoclonal antibody that inhibits angiogenesis. It has been shown to be effective in treatment of hereditary hemorrhagic telangiectasia, gastric antral vascular ectasia, and small bowel angioectasia. It has also been reported to treat hemorrhagic gastritis in a few case studies. Our case demonstrates that Bevacizumab is a promising pharmacologic treatment for radiation induced hemorrhagic gastritis." @default.
- W4316077499 created "2023-01-14" @default.
- W4316077499 creator A5001041506 @default.
- W4316077499 creator A5024591431 @default.
- W4316077499 creator A5062372369 @default.
- W4316077499 date "2022-10-01" @default.
- W4316077499 modified "2023-09-27" @default.
- W4316077499 title "S2680 A Case Report of Radiation-Induced Hemorrhagic Gastritis Successfully Treated With Bevacizumab After Failing Endoscopic and Hyperbaric Oxygen Therapies" @default.
- W4316077499 doi "https://doi.org/10.14309/01.ajg.0000867360.27770.d5" @default.
- W4316077499 hasPublicationYear "2022" @default.
- W4316077499 type Work @default.
- W4316077499 citedByCount "0" @default.
- W4316077499 crossrefType "journal-article" @default.
- W4316077499 hasAuthorship W4316077499A5001041506 @default.
- W4316077499 hasAuthorship W4316077499A5024591431 @default.
- W4316077499 hasAuthorship W4316077499A5062372369 @default.
- W4316077499 hasBestOaLocation W43160774991 @default.
- W4316077499 hasConcept C121608353 @default.
- W4316077499 hasConcept C126322002 @default.
- W4316077499 hasConcept C141071460 @default.
- W4316077499 hasConcept C2776409635 @default.
- W4316077499 hasConcept C2776694085 @default.
- W4316077499 hasConcept C2777424391 @default.
- W4316077499 hasConcept C2777789768 @default.
- W4316077499 hasConcept C2777802072 @default.
- W4316077499 hasConcept C2778248108 @default.
- W4316077499 hasConcept C2778435480 @default.
- W4316077499 hasConcept C2778451229 @default.
- W4316077499 hasConcept C2778677798 @default.
- W4316077499 hasConcept C2778792578 @default.
- W4316077499 hasConcept C2779134260 @default.
- W4316077499 hasConcept C2779810446 @default.
- W4316077499 hasConcept C2779920096 @default.
- W4316077499 hasConcept C2780479503 @default.
- W4316077499 hasConcept C2781143854 @default.
- W4316077499 hasConcept C43270747 @default.
- W4316077499 hasConcept C526805850 @default.
- W4316077499 hasConcept C71924100 @default.
- W4316077499 hasConcept C90924648 @default.
- W4316077499 hasConceptScore W4316077499C121608353 @default.
- W4316077499 hasConceptScore W4316077499C126322002 @default.
- W4316077499 hasConceptScore W4316077499C141071460 @default.
- W4316077499 hasConceptScore W4316077499C2776409635 @default.
- W4316077499 hasConceptScore W4316077499C2776694085 @default.
- W4316077499 hasConceptScore W4316077499C2777424391 @default.
- W4316077499 hasConceptScore W4316077499C2777789768 @default.
- W4316077499 hasConceptScore W4316077499C2777802072 @default.
- W4316077499 hasConceptScore W4316077499C2778248108 @default.
- W4316077499 hasConceptScore W4316077499C2778435480 @default.
- W4316077499 hasConceptScore W4316077499C2778451229 @default.
- W4316077499 hasConceptScore W4316077499C2778677798 @default.
- W4316077499 hasConceptScore W4316077499C2778792578 @default.
- W4316077499 hasConceptScore W4316077499C2779134260 @default.
- W4316077499 hasConceptScore W4316077499C2779810446 @default.
- W4316077499 hasConceptScore W4316077499C2779920096 @default.
- W4316077499 hasConceptScore W4316077499C2780479503 @default.
- W4316077499 hasConceptScore W4316077499C2781143854 @default.
- W4316077499 hasConceptScore W4316077499C43270747 @default.
- W4316077499 hasConceptScore W4316077499C526805850 @default.
- W4316077499 hasConceptScore W4316077499C71924100 @default.
- W4316077499 hasConceptScore W4316077499C90924648 @default.
- W4316077499 hasIssue "10S" @default.
- W4316077499 hasLocation W43160774991 @default.
- W4316077499 hasLocation W43160774992 @default.
- W4316077499 hasOpenAccess W4316077499 @default.
- W4316077499 hasPrimaryLocation W43160774991 @default.
- W4316077499 hasRelatedWork W1790607111 @default.
- W4316077499 hasRelatedWork W2040310096 @default.
- W4316077499 hasRelatedWork W2400467215 @default.
- W4316077499 hasRelatedWork W2977362820 @default.
- W4316077499 hasRelatedWork W2977427986 @default.
- W4316077499 hasRelatedWork W2979189509 @default.
- W4316077499 hasRelatedWork W4280528306 @default.
- W4316077499 hasRelatedWork W4316077499 @default.
- W4316077499 hasRelatedWork W4319337342 @default.
- W4316077499 hasRelatedWork W2624730983 @default.
- W4316077499 hasVolume "117" @default.
- W4316077499 isParatext "false" @default.
- W4316077499 isRetracted "false" @default.
- W4316077499 workType "article" @default.