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• W4316077877 abstract "Introduction: Epidermolysis bullosa is a rare heterogeneous group of genetic disorders of the stratified squamous epithelium, characterized by skin blistering and scarring. Dystrophic epidermolysis bullosa involves genetic mutations in COL7A1 and can result in fragility of both dermal and mucosal epithelium. Blisters and desquamation may occur spontaneously or from trauma. These patients frequently develop esophageal manifestations of their disease including esophageal blisters, stenosis and bullae formation Case Description/Methods: We present a case of a 59-year-old woman with dystrophic epidermolysis bullosa with several overt findings of her chronic condition on skin exam (Figure A) who presented with odynophagia and dysphagia. She had prior contrasted CT neck imaging at an Emergency Room with no findings to explain her symptoms and had been started on high dose H2RA therapy. An upper endoscopy for dysphagia found an upper esophageal stricture that was dilated with Savary dilation to 8 mm with mild improvement in symptoms (mucosal biopsies were found to be normal). Repeat upper endoscopy for repeat dilation revealed an upper esophageal stricture, a large mucosal bulla, and denuded sloughed mucosa (Figure B-1/2). The stricture measured 8mm in diameter. Dilation was performed with passage of a standard gastroscope, resulting in moderate mucosal tear and improved diameter of stenosis. The patient could advance her diet to a soft diet and is planned for outpatient follow up. Her odynophagia symptoms persisted however, and was treated with viscous lidocaine, magic mouthwash and proton pump inhibition Discussion: Our case illustrates the development of esophageal mucosal blistering and upper esophageal stenosis in patients with dystrophic epidermolysis bullosa. This likely stems from mechanical irritation from food intake and results in cycles of wound healing and scarring that eventually lead to stenosis and dysphagia. While strictures may occur anywhere in the esophagus, they are predominantly in the upper esophagus in this patient population and may require dilation. Endoscopists should familiarize themselves with esophageal manifestations of this rare disease and its tendency to cause upper esophageal stenosis.Figure 1.: A: Chronic skin changes of dystrophic epidermolysis bullosa. B1: Esophageal bullae and blistering. B2: Denuded esophageal mucosa." @default.
• W4316077877 created "2023-01-14" @default.
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• W4316077877 date "2022-10-01" @default.
• W4316077877 modified "2023-09-27" @default.
• W4316077877 title "S2308 Epidermolysis Bullosa: A Rare Cause of Upper Esophageal Stenosis" @default.
• W4316077877 doi "https://doi.org/10.14309/01.ajg.0000865872.96468.fe" @default.
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