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• W4316078045 abstract "Introduction: Parkinson’s disease (PD) is a grave neurodegenerative disorder characterized by motor and non-motor symptoms. Constipation is a major disabling non-motor symptom that enormously affects the quality of life. It is one of the most common functional gastrointestinal disorders in patients with PD. Our study aimed to evaluate the prevalence of Constipation and its impact on resource utilization in hospitalized patients with PD in the US. Methods: National Inpatient Sample (NIS) for 2019 was queried using ICD-10-CM Codes to identify a cohort of inpatient admissions with a primary discharge diagnosis of PD with and without a secondary diagnosis of Constipation. A weighted sample was used to get baseline characteristics and resource utilization during the inpatient admissions. Multivariate linear regression analysis followed by predictive margins was used to obtain adjusted estimates of the length of stay and total hospital charges. (Figure) Results: Among 21125 patients admitted with PD, 2860 (13.5%) patients had a concurrent diagnosis of Constipation. Mean age was similar in PD patients with or without Constipation (74 years vs. 75.1 years). In adjusted analysis, Constipation was associated with a significantly longer length of hospital stay in PD patients with Constipation compared to without, 8.56 days vs. 5.89 days, respectively (p-value < 0.01). A lesser number of PD patients with Constipation were discharged home than those without Constipation (18.7% vs. 32.7%, p-value < 0.01). A higher percentage of Constipated PD patients were discharged to skilled nursing facilities compared to non-constipated PD patients (51.2% vs. 43.1%). There was no statistically significant difference in hospital charges between the two groups. (Table) Conclusion: Our study showed a high prevalence of Constipation among hospitalized patients with PD. The presence of Constipation leads to an increased length of stay. In addition, these patients are more likely to be discharged to skilled nursing facilities, which can increase overall healthcare costs. Careful assessment and prompt intervention to address Constipation is required for these hospitalized patients. It will help mitigate adverse outcomes in these patients, improve quality of life and decrease the economic burden on the health system.Figure 1.: PD: Parkinson's Disease; PD+constipation: Parkinson's Disease with Constipation Table 1. - Adjusted for Age, Charlson Comorbidity Index, Hospital (Location, Teaching status), Insurance status, Malnutrition Variables Parkinson’s without Constipation(18265) Parkinson’s with Constipation(2860) p-value a) Baseline Patient and Hospital Characteristics Age (SD) 74.0 (9.8) 75.1 (8.7) 0.01 Female (%) 6175 (33.8) 950 (33.2) 0.78 Race (%) 0.38 White 14210 (79.7) 2145 (77.2) Charlson Comorbidity Index (SD) 1.6 (1.7) 1.8 (1.7) 0.02 Hospital Type (%) Urban 16810 (92.0) 2660 (93.0) 0.41 Teaching 13985 (76.6) 2305 (80.6) 0.05 Hospital Bed Size (Large) 9935 (54.4) 1520 (53.2) 0.34 Payer Information (%) < 0.01 Medicare 15020 (84.1) 2545 (90.1) Private Insurance 2275 (12.7) 180 (6.4) Disposition (%) < 0.01 Home SNFDied 5970 (32.7)7860 (43.1)200 (1.1) 535 (18.7)1465 (51.2)10 (0.4) Malnutrition 1660 (9.1) 365 (12.8) 0.01 b) Resource Utilization LOS (Unadjusted) 5.83 (95% CI 5.47-6.18) 8.56 (95% CI 7.84-9.28) < 0.01 LOS (Adjusted) 5.89 (95% CI 5.56-6.22) 8.41 (95% CI 7.70-9.13) < 0.01 TOTAL CHARGES (Unadjusted) 59555 (95% CI 56066-63043) 56882 (95% CI 52109-61656) 0.31 TOTAL CHARGES (Adjusted) 59419 (95% CI 56292-62547) 57770 (95% CI 52983-62557) 0.51 SD: Standard Deviation ; SNF: Skilled Nursing Facility; LOS: Length of Stay." @default.
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• W4316078045 date "2022-10-01" @default.
• W4316078045 modified "2023-10-10" @default.
• W4316078045 title "S555 Impact of Constipation on Resource Utilization in Patients with Parkinson’s Disease: A Nationwide Analysis" @default.
• W4316078045 doi "https://doi.org/10.14309/01.ajg.0000858860.23950.61" @default.
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