Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316078871> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4316078871 endingPage "e96" @default.
- W4316078871 startingPage "e96" @default.
- W4316078871 abstract "Introduction: Circulating tumor DNA (ctDNA) derived from apoptotic tumor cells is rapidly emerging as a non-invasive biomarker to detect the presence of tumor at a molecular level and guide therapy. In this study, we present our experience with this novel marker in gastrointestinal malignancy (GIM) patients. Methods: We included all patients with GIM for whom ctDNA was ordered from January 2020 to July 2021 at our center. Patient demographics, tumor type, pathology, stage, and radiographic findings were collected. Descriptive statistics were employed to report findings. Results: We identified 62 GIM patients for whom ctDNA was ordered. Results for 6 patients were not reported due to insufficient tumor tissue. Of the 56 patients for whom ctDNA results were available, 46 (82%) had colorectal adenocarcinoma (CRC) and the rest had other GI malignancies. Of the overall cohort of 56 evaluable patients, 21 (37.5%) had metastatic disease. Imaging findings paralleled ctDNA levels and correlated with tumor burden in 30 patients (53.5%). In 13 patients (23.2%), undetectable CT DNA levels influenced decisions regarding systemic therapy in addition to acting as a surrogate for treatment response. We discontinued maintenance therapy in 5 metastatic CRC patients with negative ctDNA and imaging. These patients have been off treatment for > 12 months without evidence of recurrence. We also truncated or skipped adjuvant treatment in 6 Stage III CRC patients with negative ctDNA and imaging who had significant post-operative complications or were otherwise considered high risk for severe toxicity. In one CRC patient, ctDNA was found to be undetectable post neoadjuvant therapy which corroborated with pathological complete response on surgical pathology report. 5 patients (9.09 %) had false-negative results and 1 patient had falsely elevated levels. In 6 other patients, we could not draw significant conclusions due to the availability of only a single value. Conclusion: Our experience suggests that ctDNA is not only a sensitive tool to assess tumor burden, but can also help guide therapy in locally advanced and metastatic CRC patients. However, further prospective studies are needed to improve the accuracy of test results and integrate ctDNA in day-to-day clinical practice." @default.
- W4316078871 created "2023-01-14" @default.
- W4316078871 creator A5044596488 @default.
- W4316078871 creator A5066058015 @default.
- W4316078871 creator A5081648312 @default.
- W4316078871 creator A5091775916 @default.
- W4316078871 date "2022-10-01" @default.
- W4316078871 modified "2023-10-18" @default.
- W4316078871 title "S131 Clinical Application of Circulating Tumor DNA in Gastrointestinal Cancer Patients" @default.
- W4316078871 doi "https://doi.org/10.14309/01.ajg.0000857164.92051.f8" @default.
- W4316078871 hasPublicationYear "2022" @default.
- W4316078871 type Work @default.
- W4316078871 citedByCount "0" @default.
- W4316078871 crossrefType "journal-article" @default.
- W4316078871 hasAuthorship W4316078871A5044596488 @default.
- W4316078871 hasAuthorship W4316078871A5066058015 @default.
- W4316078871 hasAuthorship W4316078871A5081648312 @default.
- W4316078871 hasAuthorship W4316078871A5091775916 @default.
- W4316078871 hasBestOaLocation W43160788711 @default.
- W4316078871 hasConcept C121608353 @default.
- W4316078871 hasConcept C126322002 @default.
- W4316078871 hasConcept C143998085 @default.
- W4316078871 hasConcept C146357865 @default.
- W4316078871 hasConcept C151730666 @default.
- W4316078871 hasConcept C185592680 @default.
- W4316078871 hasConcept C2777982462 @default.
- W4316078871 hasConcept C2779134260 @default.
- W4316078871 hasConcept C2779399171 @default.
- W4316078871 hasConcept C2781182431 @default.
- W4316078871 hasConcept C2781197716 @default.
- W4316078871 hasConcept C2781335228 @default.
- W4316078871 hasConcept C526805850 @default.
- W4316078871 hasConcept C542804219 @default.
- W4316078871 hasConcept C55493867 @default.
- W4316078871 hasConcept C71924100 @default.
- W4316078871 hasConcept C72563966 @default.
- W4316078871 hasConcept C86803240 @default.
- W4316078871 hasConcept C90924648 @default.
- W4316078871 hasConceptScore W4316078871C121608353 @default.
- W4316078871 hasConceptScore W4316078871C126322002 @default.
- W4316078871 hasConceptScore W4316078871C143998085 @default.
- W4316078871 hasConceptScore W4316078871C146357865 @default.
- W4316078871 hasConceptScore W4316078871C151730666 @default.
- W4316078871 hasConceptScore W4316078871C185592680 @default.
- W4316078871 hasConceptScore W4316078871C2777982462 @default.
- W4316078871 hasConceptScore W4316078871C2779134260 @default.
- W4316078871 hasConceptScore W4316078871C2779399171 @default.
- W4316078871 hasConceptScore W4316078871C2781182431 @default.
- W4316078871 hasConceptScore W4316078871C2781197716 @default.
- W4316078871 hasConceptScore W4316078871C2781335228 @default.
- W4316078871 hasConceptScore W4316078871C526805850 @default.
- W4316078871 hasConceptScore W4316078871C542804219 @default.
- W4316078871 hasConceptScore W4316078871C55493867 @default.
- W4316078871 hasConceptScore W4316078871C71924100 @default.
- W4316078871 hasConceptScore W4316078871C72563966 @default.
- W4316078871 hasConceptScore W4316078871C86803240 @default.
- W4316078871 hasConceptScore W4316078871C90924648 @default.
- W4316078871 hasIssue "10S" @default.
- W4316078871 hasLocation W43160788711 @default.
- W4316078871 hasLocation W43160788712 @default.
- W4316078871 hasOpenAccess W4316078871 @default.
- W4316078871 hasPrimaryLocation W43160788711 @default.
- W4316078871 hasRelatedWork W134396366 @default.
- W4316078871 hasRelatedWork W1999173109 @default.
- W4316078871 hasRelatedWork W2072537511 @default.
- W4316078871 hasRelatedWork W2155078208 @default.
- W4316078871 hasRelatedWork W2965269027 @default.
- W4316078871 hasRelatedWork W3097634536 @default.
- W4316078871 hasRelatedWork W3199290465 @default.
- W4316078871 hasRelatedWork W4205679791 @default.
- W4316078871 hasRelatedWork W4220654808 @default.
- W4316078871 hasRelatedWork W4245038221 @default.
- W4316078871 hasVolume "117" @default.
- W4316078871 isParatext "false" @default.
- W4316078871 isRetracted "false" @default.
- W4316078871 workType "article" @default.