Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316081204> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4316081204 endingPage "e2197" @default.
- W4316081204 startingPage "e2197" @default.
- W4316081204 abstract "Introduction: Whipple’s disease (WD) is a rare disorder caused by the pathogen Tropheryma whipplei. It presents with non-specific symptoms which can mimic the presentation of other gastrointestinal pathogens, especially in immunocompromised patients. We report a unique presentation of WD involving an immunocompromised patient who experienced non-specific gastrointestinal symptoms without arthralgia, which is a characteristic symptom of this disease. Case Description/Methods: A 67-year-old man with a history of chronic hepatitis B infection and Human immunodeficiency virus (HIV) infection presented with weight loss, nausea, vomiting and myalgia. Of note, patient did not have arthralgia. Physical exam revealed cervical lymphadenopathy and diffuse abdominal tenderness. Patient was anemic (hemoglobin of 8.6 g/dL) with a normal white count. Endoscopy demonstrated erythema in the gastric body, lymphangiectasia of the duodenum, and increased granularity of the terminal ileum. Mucosal biopsies revealed macrophages in the lamina propria with focal histiocytic aggregates throughout the small bowel and cecum, with positive PAS staining, consistent with Whipple’s disease. Confirmatory T. whipplei PCR testing was positive (Figure). Discussion: WD is a rare diagnosis that must be considered in the differential diagnoses of patients presenting with unexplained nausea, vomiting, diarrhea and anemia. Furthermore, in patients with HIV, the possibilities would also include opportunistic gastrointestinal pathogens. Classic WD is characterized by diarrhea, weight loss, abdominal pain and extra-intestinal involvement manifesting as joint pain, endocarditis, dementia, supranuclear gaze palsy, and mediastinal lymphadenopathy. Diagnosis involves biopsy of affected tissue demonstrating foamy macrophages with PAS (+) substance, which can be confirmed by PCR or immunohistochemistry. Treatment involves an initial course of penicillin or ceftriaxone followed by a prolonged course of Bactrim, or a one-year course of doxycycline and hydroxychloroquine, followed by lifelong doxycycline therapy, which is more likely to prevent disease relapse. In the absence of suppressive therapy, relapse of WD is common and may lead to further complications, including neurological involvement.Figure 1.: Periodic Acid-Schiff-Staining Macrophages (circles) Within the Lamina Propria of the Duodenal Bulb (a) and Cecum (b) as Seen Via Light Microscopy with a 20x Objective Lens." @default.
- W4316081204 created "2023-01-14" @default.
- W4316081204 creator A5006128253 @default.
- W4316081204 creator A5067589494 @default.
- W4316081204 creator A5082109727 @default.
- W4316081204 creator A5082741029 @default.
- W4316081204 date "2022-10-01" @default.
- W4316081204 modified "2023-10-18" @default.
- W4316081204 title "S3494 Whipple’s Disease Without Arthropathy in an Immunocompromised Patient" @default.
- W4316081204 doi "https://doi.org/10.14309/01.ajg.0000870616.85474.12" @default.
- W4316081204 hasPublicationYear "2022" @default.
- W4316081204 type Work @default.
- W4316081204 citedByCount "0" @default.
- W4316081204 crossrefType "journal-article" @default.
- W4316081204 hasAuthorship W4316081204A5006128253 @default.
- W4316081204 hasAuthorship W4316081204A5067589494 @default.
- W4316081204 hasAuthorship W4316081204A5082109727 @default.
- W4316081204 hasAuthorship W4316081204A5082741029 @default.
- W4316081204 hasBestOaLocation W43160812041 @default.
- W4316081204 hasConcept C126322002 @default.
- W4316081204 hasConcept C142724271 @default.
- W4316081204 hasConcept C2777440137 @default.
- W4316081204 hasConcept C2779134260 @default.
- W4316081204 hasConcept C2780349322 @default.
- W4316081204 hasConcept C2780647328 @default.
- W4316081204 hasConcept C2780852908 @default.
- W4316081204 hasConcept C2780955771 @default.
- W4316081204 hasConcept C2909022844 @default.
- W4316081204 hasConcept C3019900444 @default.
- W4316081204 hasConcept C71924100 @default.
- W4316081204 hasConcept C90924648 @default.
- W4316081204 hasConceptScore W4316081204C126322002 @default.
- W4316081204 hasConceptScore W4316081204C142724271 @default.
- W4316081204 hasConceptScore W4316081204C2777440137 @default.
- W4316081204 hasConceptScore W4316081204C2779134260 @default.
- W4316081204 hasConceptScore W4316081204C2780349322 @default.
- W4316081204 hasConceptScore W4316081204C2780647328 @default.
- W4316081204 hasConceptScore W4316081204C2780852908 @default.
- W4316081204 hasConceptScore W4316081204C2780955771 @default.
- W4316081204 hasConceptScore W4316081204C2909022844 @default.
- W4316081204 hasConceptScore W4316081204C3019900444 @default.
- W4316081204 hasConceptScore W4316081204C71924100 @default.
- W4316081204 hasConceptScore W4316081204C90924648 @default.
- W4316081204 hasIssue "10S" @default.
- W4316081204 hasLocation W43160812041 @default.
- W4316081204 hasLocation W43160812042 @default.
- W4316081204 hasOpenAccess W4316081204 @default.
- W4316081204 hasPrimaryLocation W43160812041 @default.
- W4316081204 hasRelatedWork W1579084896 @default.
- W4316081204 hasRelatedWork W175455664 @default.
- W4316081204 hasRelatedWork W1765127671 @default.
- W4316081204 hasRelatedWork W1997789666 @default.
- W4316081204 hasRelatedWork W2411305180 @default.
- W4316081204 hasRelatedWork W2946367991 @default.
- W4316081204 hasRelatedWork W2947228709 @default.
- W4316081204 hasRelatedWork W2965868576 @default.
- W4316081204 hasRelatedWork W3013979433 @default.
- W4316081204 hasRelatedWork W4309385490 @default.
- W4316081204 hasVolume "117" @default.
- W4316081204 isParatext "false" @default.
- W4316081204 isRetracted "false" @default.
- W4316081204 workType "article" @default.