FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316081840> ?p ?o ?g. }

• W4316081840 endingPage "e819" @default.
• W4316081840 startingPage "e819" @default.
• W4316081840 abstract "Introduction: A submucosal injection is an essential technique for endoscopic submucosal dissection (ESD) to lift the lesion. Not only does this facilitate en-bloc resection, but it also provides sufficient submucosa for proper pathologic evaluation of margin and lymphovascular invasion. Several injection agents for ESD have been developed, including ORISE Gel (Boston Scientific, MA, USA) and Eleview (Aries Pharmaceutical, CA, USA), however, few studies have examined the clinical outcomes of each lifting agent. Here we compared the clinical outcomes of ORISE Gel and Eleview used during the ESD of colorectal lesions. Methods: A total of 90 patients who underwent ESD were included in this retrospective cohort study. 2mm Dual-J Knife (Olympus) or 1.5mm ProKnife (Boston Scientifics) were used for resection. Patients were divided into a comparison group: ORISE group (n=36) vs Eleview group (n=54). The primary outcome was the amount of each agent used to achieve adequate submucosal lifting. Secondary outcomes were en-bloc resection rate, R0 resection rates, ESD time, length of hospital stay, and adverse events. R0 resection was defined as an en-bloc resection with microscopically negative margins. The two groups were compared using the Independent t-tests and chi-square tests. Results: The ORISE group had a significantly lower amount of agent used (30 mL vs 65.5 ml, p< 0.001) and shorter procedure time (90.0 min vs 120.0 min, p=0.05) when compared with the Eleview group, while there was no difference in en-bloc resection rate (77.8% vs 70.4%, p=0.48), R0 resection rate (61.1% vs 59.3%, p=0.83) hospital length of stay (1.03±0.70 vs 1.39±2.41, p=0.39), or adverse events (16.7% vs 11.1%, p=0.53). (Table) Conclusion: The use of ORISE for colorectal ESD was significantly associated with a lower amount of gel used for submucosal lifting and shorter procedure time while there were no differences in the en-bloc resection or R0 resection rates, hospital length of stays, and adverse events compared to Eleview. Further study is warranted to investigate the clinical outcomes of different lifting agents used for ESD. Table 1. - Baseline Characteristics and Outcomes of Colorectal Endoscopic Submucosal Dissection LGD=low-grade dysplasia, HGD=high-grade dysplasia Eleview (n=54) Orise (n=36) Baseline characteristics Age, y, median (IQR) 58 (54.5-66.5) 64 (56.3-73.0) Sex, men/women, n 31/23 18/18 Lesion size, mm, median (IQR) 31 (22.3-44.8) 29.5 (20.0-34.0) ASA class, n (%) Ⅰ 2 3.7 0 0 Ⅱ 24 44.4 9 25.0 Ⅲ 26 48.1 27 75.0 Ⅳ 2 3.7 0 0.0 Lesion site, n (%) Iloececal valve 5 9.3 2 5.6 Cecum 15 27.8 9 25.0 Ascending colon 11 20.4 6 16.7 Hepatic flexure 2 3.7 0 0.0 Transverse colon 9 16.7 11 30.6 Splenic flexure 1 1.9 0 0.0 Descending colon 3 5.6 2 5.6 Sigmoid colon 8 14.8 6 16.7 Anesthesia, n (%) Profopol 23 42.6 24 66.7 General anesthesia 31 57.4 12 33.3 Histology, n (%) Nondyspastic colon mucosa 25 46.3 14 38.9 Adenoma with LDG 0 0.0 5 13.9 Adenoma with HGD 16 29.6 9 25.0 pT1a 2 3.7 3 8.3 pT1b 7 13.0 2 5.6 Sessile serrated polyp 1 1.9 3 8.3 Sessile serrated polyp with dysplasia 3 5.6 0 0.0 p-value Outcomes Amount of injection, mL, median (IQR) 65.5 (40.0-100.0) 30 (20.0-48.0) < 0.001 Procedure time, min, median (IQR) 120 (90.0-168.75) 90 (73.75-142.5) 0.05 En bloc resection, n (%) 38 70.4 28 77.8 0.48 R0 resection, n (%) 32 59.3 22 61.1 0.83 Hospital length of stay, d, mean ± SD 1.39 2.406 1.03 0.7 0.39 Adverse event, n (%) 6 11.1 6 16.7 0.53 Type of adverse event Delayed bleeding 5 9.3 2 3.7 Perforation 1 1.9 0 0 Infection 0 0 1 1.9 Hypotension 0 0 2 3.7 Arrhythmia 0 0 1 1.9" @default.
• W4316081840 created "2023-01-14" @default.
• W4316081840 creator A5040211001 @default.
• W4316081840 creator A5043761635 @default.
• W4316081840 creator A5049822683 @default.
• W4316081840 creator A5057308217 @default.
• W4316081840 creator A5081739829 @default.
• W4316081840 date "2022-10-01" @default.
• W4316081840 modified "2023-09-27" @default.
• W4316081840 title "S1124 Optimal Submucosal Injection for Submucosal Dissection: A Single-Center Experience" @default.
• W4316081840 doi "https://doi.org/10.14309/01.ajg.0000861136.62502.6f" @default.
• W4316081840 hasPublicationYear "2022" @default.
• W4316081840 type Work @default.
• W4316081840 citedByCount "0" @default.
• W4316081840 crossrefType "journal-article" @default.
• W4316081840 hasAuthorship W4316081840A5040211001 @default.
• W4316081840 hasAuthorship W4316081840A5043761635 @default.
• W4316081840 hasAuthorship W4316081840A5049822683 @default.
• W4316081840 hasAuthorship W4316081840A5057308217 @default.
• W4316081840 hasAuthorship W4316081840A5081739829 @default.
• W4316081840 hasBestOaLocation W43160818401 @default.
• W4316081840 hasConcept C121608353 @default.
• W4316081840 hasConcept C126322002 @default.
• W4316081840 hasConcept C141071460 @default.
• W4316081840 hasConcept C159110652 @default.
• W4316081840 hasConcept C167135981 @default.
• W4316081840 hasConcept C2777137803 @default.
• W4316081840 hasConcept C2778132481 @default.
• W4316081840 hasConcept C2778740770 @default.
• W4316081840 hasConcept C2778866283 @default.
• W4316081840 hasConcept C2779013556 @default.
• W4316081840 hasConcept C2779052585 @default.
• W4316081840 hasConcept C2780073493 @default.
• W4316081840 hasConcept C2781156865 @default.
• W4316081840 hasConcept C71924100 @default.
• W4316081840 hasConceptScore W4316081840C121608353 @default.
• W4316081840 hasConceptScore W4316081840C126322002 @default.
• W4316081840 hasConceptScore W4316081840C141071460 @default.
• W4316081840 hasConceptScore W4316081840C159110652 @default.
• W4316081840 hasConceptScore W4316081840C167135981 @default.
• W4316081840 hasConceptScore W4316081840C2777137803 @default.
• W4316081840 hasConceptScore W4316081840C2778132481 @default.
• W4316081840 hasConceptScore W4316081840C2778740770 @default.
• W4316081840 hasConceptScore W4316081840C2778866283 @default.
• W4316081840 hasConceptScore W4316081840C2779013556 @default.
• W4316081840 hasConceptScore W4316081840C2779052585 @default.
• W4316081840 hasConceptScore W4316081840C2780073493 @default.
• W4316081840 hasConceptScore W4316081840C2781156865 @default.
• W4316081840 hasConceptScore W4316081840C71924100 @default.
• W4316081840 hasIssue "10S" @default.
• W4316081840 hasLocation W43160818401 @default.
• W4316081840 hasLocation W43160818402 @default.
• W4316081840 hasOpenAccess W4316081840 @default.
• W4316081840 hasPrimaryLocation W43160818401 @default.
• W4316081840 hasRelatedWork W102034531 @default.
• W4316081840 hasRelatedWork W1907519577 @default.
• W4316081840 hasRelatedWork W2005631252 @default.
• W4316081840 hasRelatedWork W2121829882 @default.
• W4316081840 hasRelatedWork W2367716467 @default.
• W4316081840 hasRelatedWork W2587767046 @default.
• W4316081840 hasRelatedWork W2601245836 @default.
• W4316081840 hasRelatedWork W2947833179 @default.
• W4316081840 hasRelatedWork W55955857 @default.
• W4316081840 hasRelatedWork W2095759942 @default.
• W4316081840 hasVolume "117" @default.
• W4316081840 isParatext "false" @default.
• W4316081840 isRetracted "false" @default.
• W4316081840 workType "article" @default.