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• W4316082112 abstract "Introduction: Gastroesophageal reflux disease (GERD) is a chronic disease caused by the reflux of the gastric contents into the esophagus. The chronic symptoms of GERD have been shown to negatively impact the psychological and function status of these patients. Therefore, we examined the prevalence of various psychiatric disorders in patients with GERD and factors associated with them. Methods: We queried a multicenter database (Explorys Inc, Cleveland, OH) which includes electronic health record data from 26 major integrated US healthcare systems from 1999 to 2022. A cohort of patients with a Systematized Nomenclature of Medicine – Clinical Terms (SNOMED-CT) was identified. We identified patients diagnosed with GERD. We collected demographic data, co-morbidities and psychiatric disorders including: anxiety, depression, bipolar disorder, eating disorder, and autistic disorder. Univariate and multivariate analyses were performed using Statistical Package for Social Sciences version 25. Results: Of the 70, 301,380 adult individuals ( >18 yr old) in the database from 1999 to present, we identified 6,748,3850 patients with GERD (9.7%). Table summarizes the demographic characteristics and co-morbidities of patients in cohort. In univariate analysis, when compared to patients with no history of GERD (controls), GERD patients (cases) were more likely to have anxiety disorder (OR 5.77 [5.76-5.78)]), depression (OR 6.22 [6.21-6.23]), bipolar disorder (OR 4.00 [3.98-4.02], eating disorder (OR 4.58 [4.54-4.62]), and autistic disorder (OR 1.98 [1.95-2.02]) (Table). In multivariate analysis adjusted for age, gender and race, we re-enforced that GERD was independently associated with higher risk for anxiety (OR 2.84 [2.84-2.85]), depression (3.60 [3.59-3.61]), bipolar disorder (1.34 [1.33-1.34]), eating disorder (1.37 [1.35-1.38]) and autistic disorder (1.17 [1.15-1.20]). (Figure) Conclusion: In this large study, we found a higher prevalence of various psychiatric diseases including anxiety, depression, bipolar, eating disorder and autism disorder in GERD patients. Further clinical studies exploring the relationship between GERD and psychiatric disorders are required.Figure 1.: Multivariate analysis for psychiatric diagnoses in GERD patients. Table 1. - Baseline Characteristic of Patients with GERD (cases) and without GERD (Controls) GERD Non-GERD OR 95% CI Number (Percentage) Number (Percentage) Total 6,748,850 9.7% 62,556,240 90.2% Age ( years) 18-65 3,408,520 51% 44,297,610 71% 0.48 (0.48-0.48) >65 2,734,010 49% 17,166,600. 27% 2.53 (2.53-2.54) Gender Male 3,301,680 41% 28,127,780 45% 0.83 (0.83-0.83) Female 3,998,130 59% 33,959,060 54% 1.22 (1.22-1.23) Race Caucasian 4,999,030 74% 32,318,160 52% 2.67 (2.66-2.68) African American 776,650 12% 6,219,520 10% 1.26 (1.25-1.27) Hispanic 59,240 1% 837,650 1% 0.91 (0.89-0.93) Comorbidities Smoker 921,230 14% 2,894,580 5% 3.26 (3.25-.266) Alcohol abuse 269,370 4% 822,040 1% 3.12 (3.10-3.13) Substance abuse 506,360 8% 1,687,010 3% 2.92 (2.91-2.93) DM 1,784,190 26% 4,348,050 7% 4.81 (4.80-4.82) HTN 4,073,950 60% 10,130,140 16% 7.88 (7.86-7.89) HLD 3,777,920 56% 8,016,350 13% 8.65 (8.63-8.66) Obesity 1,827,180 27% 3,620,490 6% 6.04 (6.03-6.05) Anxiety Disorder 1,877,090 28% 3,912,810 6% 5.77 (5.76-5.78) Depression Disorder 2,249,150 33% 4,651,070 7% 6.22 (6.21-6.23) Bipolar disorder 312,920 5% 750,170 1% 4.00 (3.98-4.02) Eating Disorder 63,090 1% 128,500 0.2% 4.58 (4.54-4.62) Autistic disorder 15,450 0.2% 72,220 0.1% 1.98 (1.95-2.02) Abbreviations: GERD: Gastroesophageal reflux disease; DM: Diabetes mellitus; HTN: Hypertension; HLD: Hyperlipidemia." @default.
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• W4316082112 date "2022-10-01" @default.
• W4316082112 modified "2023-09-28" @default.
• W4316082112 title "S495 Epidemiology and Risk of Psychiatric Disorders Among Patients with Gastroesophageal Reflux Disease: A Population-Based National Study" @default.
• W4316082112 doi "https://doi.org/10.14309/01.ajg.0000858620.93010.e5" @default.
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