Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316082246> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4316082246 endingPage "e1398" @default.
- W4316082246 startingPage "e1397" @default.
- W4316082246 abstract "Introduction: Medullary carcinoma of the colon (MCC) represents < 3% of colon cancers and is characterized by microsatellite instability (MSI) leading to poor cellular differentiation. With its relative rarity and ambiguous histology, MCC remains a challenging, frequently-missed diagnosis. Case Description/Methods: A 56-year-old post-menopausal female with asymptomatic iron-deficiency anemia was referred to gastroenterology for bidirectional endoscopy. Colonoscopy identified multiple colonic polyps and a mass nearly obstructing the ascending colon. Abdominopelvic CT showed an 8.1 cm mass with associated mesenteric lymph nodes but no extracolonic involvement. CEA levels were normal. Initial biopsy demonstrated poor tumor differentiation. Immunohistochemical staining was positive for CD45, a marker of lymphocytic infiltration, but negative for cytokeratin (CK) 20, caudal-related homeobox gene 2 (CDX-2), and synaptophysin, interpreted as an undifferentiated carcinoma. The patient was referred to colorectal surgery and underwent laparoscopic right hemicolectomy without complication. Biopsy of the resected tumor redemonstrated the initial biopsy results without lymph node involvement. Additional stains showed high MSI and negativity for extracolonic tumor markers. These findings confirmed the tumor as a non-adenocarcinoma primary colonic lesion suggestive of MCC. Discussion: The differential diagnosis for poorly-differentiated colonic tumors includes poorly-differentiated adenocarcinoma (PDA), neuroendocrine tumor (NET), MCC, and metastasis. This ambiguity has led to tumor misidentification in up to 66% of MCC cases; however, several key features can distinguish among these carcinomas. MCC displays negative chromogranin and synaptophysin staining, unlike NET. MCC almost invariably has high MSI and is infrequently CK20 and CDX-2 positive, unlike PDA. Clinically, MCC is more likely to present in the eighth decade, in females, and in the right colon than NET or PDA. MCC frequently follows an indolent course with good prognosis, while PDA often grows and spreads aggressively. While this case had a uniquely young age of presentation, it otherwise exhibits known clinical and histological features of MCC. As familiarity with these features rises and the use of MSI testing expands, accurate diagnosis of MCC will likely improve. With the expansion of colon cancer screening, the incidence of MCC is likely to rise, highlighting the importance of timely, accurate diagnosis when facing poorly-differentiated colonic tumors." @default.
- W4316082246 created "2023-01-14" @default.
- W4316082246 creator A5021142671 @default.
- W4316082246 creator A5040921943 @default.
- W4316082246 creator A5064409313 @default.
- W4316082246 date "2022-10-01" @default.
- W4316082246 modified "2023-10-01" @default.
- W4316082246 title "S2040 Hiding in Plain Sight: The Challenge of Diagnosing Medullary Carcinoma of the Colon" @default.
- W4316082246 doi "https://doi.org/10.14309/01.ajg.0000864800.71612.9a" @default.
- W4316082246 hasPublicationYear "2022" @default.
- W4316082246 type Work @default.
- W4316082246 citedByCount "0" @default.
- W4316082246 crossrefType "journal-article" @default.
- W4316082246 hasAuthorship W4316082246A5021142671 @default.
- W4316082246 hasAuthorship W4316082246A5040921943 @default.
- W4316082246 hasAuthorship W4316082246A5064409313 @default.
- W4316082246 hasBestOaLocation W43160822461 @default.
- W4316082246 hasConcept C104317684 @default.
- W4316082246 hasConcept C121608353 @default.
- W4316082246 hasConcept C126322002 @default.
- W4316082246 hasConcept C142724271 @default.
- W4316082246 hasConcept C180754005 @default.
- W4316082246 hasConcept C185592680 @default.
- W4316082246 hasConcept C204232928 @default.
- W4316082246 hasConcept C2775934546 @default.
- W4316082246 hasConcept C2777209535 @default.
- W4316082246 hasConcept C2778435480 @default.
- W4316082246 hasConcept C2779767149 @default.
- W4316082246 hasConcept C2780801072 @default.
- W4316082246 hasConcept C2781182431 @default.
- W4316082246 hasConcept C526805850 @default.
- W4316082246 hasConcept C55493867 @default.
- W4316082246 hasConcept C61320498 @default.
- W4316082246 hasConcept C71924100 @default.
- W4316082246 hasConceptScore W4316082246C104317684 @default.
- W4316082246 hasConceptScore W4316082246C121608353 @default.
- W4316082246 hasConceptScore W4316082246C126322002 @default.
- W4316082246 hasConceptScore W4316082246C142724271 @default.
- W4316082246 hasConceptScore W4316082246C180754005 @default.
- W4316082246 hasConceptScore W4316082246C185592680 @default.
- W4316082246 hasConceptScore W4316082246C204232928 @default.
- W4316082246 hasConceptScore W4316082246C2775934546 @default.
- W4316082246 hasConceptScore W4316082246C2777209535 @default.
- W4316082246 hasConceptScore W4316082246C2778435480 @default.
- W4316082246 hasConceptScore W4316082246C2779767149 @default.
- W4316082246 hasConceptScore W4316082246C2780801072 @default.
- W4316082246 hasConceptScore W4316082246C2781182431 @default.
- W4316082246 hasConceptScore W4316082246C526805850 @default.
- W4316082246 hasConceptScore W4316082246C55493867 @default.
- W4316082246 hasConceptScore W4316082246C61320498 @default.
- W4316082246 hasConceptScore W4316082246C71924100 @default.
- W4316082246 hasIssue "10S" @default.
- W4316082246 hasLocation W43160822461 @default.
- W4316082246 hasLocation W43160822462 @default.
- W4316082246 hasOpenAccess W4316082246 @default.
- W4316082246 hasPrimaryLocation W43160822461 @default.
- W4316082246 hasRelatedWork W1949542297 @default.
- W4316082246 hasRelatedWork W1996195452 @default.
- W4316082246 hasRelatedWork W2044761979 @default.
- W4316082246 hasRelatedWork W2216182644 @default.
- W4316082246 hasRelatedWork W2245625516 @default.
- W4316082246 hasRelatedWork W2364973444 @default.
- W4316082246 hasRelatedWork W2387773904 @default.
- W4316082246 hasRelatedWork W2587429229 @default.
- W4316082246 hasRelatedWork W2619182103 @default.
- W4316082246 hasRelatedWork W33978073 @default.
- W4316082246 hasVolume "117" @default.
- W4316082246 isParatext "false" @default.
- W4316082246 isRetracted "false" @default.
- W4316082246 workType "article" @default.