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- W4316084807 abstract "Introduction: Recent studies have shown the role of inflammatory markers, especially the neutrophil-to-lymphocyte Ratio (NLR), as indicators of poor prognosis in various gastrointestinal malignancies. We aimed to examine the prognostic value of NLR, among other markers, and their relationship with the presence of baseline distant metastasis in patients with gastric adenocarcinoma. Methods: We retrospectively reviewed the charts of 502 patients with gastric adenocarcinoma treated at a tertiary care cancer center from 2012 to 2018. We examined the relationship between absolute eosinophilic count (AEC), absolute lymphocyte count (ALC), absolute monocytic count (AMC), absolute neutrophil count (ANC), monocyte to lymphocyte ratio (MLR), NLR, and platelet to lymphocyte ratio (PLR) with the presence distant metastases, and overall survival (OS). We used multivariable logistic regression analyses to test the association between the variables and the presence of baseline distant metastases. Results: The median age was 54 years, and males comprised 56% of the patients. The ROC value of 3.9 was determined as the cutoff value for NLR. High NLR (NLR > 3.9 µL) was significantly associated with the presence of distant metastasis at diagnosis (P-value: 0.0001, OR: 0.5, 95% CI: 0.3–0.7). High ANC (≥6015/μL), AEC (≥215 /μL), and PLR (≥0.15) were significantly associated with baseline distant metastases (P-value: 0.024, 0.001, and 0.001 respectively). Multivariable analysis showed that high NLR (P-value, 0.0005, OR: 0.5, CI: 0.32–0.74) was an independent risk factor for distant metastasis at presentation. High baseline ANC, NLR, MLR, and PLR were associated with poor OS (P-value: 0.0455, 0.0003, 0.0270, and < 0.0001, respectively) (Table, Figure). Conclusion: High systemic inflammatory markers are associated with poor prognosis (the presence of distant metastasis) and poor OS in patients with gastric cancer. Simple laboratory tests such as complete blood counts can be used as markers of poor prognosis and poor OS in patients with gastric cancer.Figure 1.: A) Kaplan Meier curve for overall survival with NLR. B) Kaplan Meier curve for overall survival with MLR. C) Kaplan Meier curve for overall survival with PLR Table 1. - The association between systemic inflammatory markers with the presence of distant metastases Baseline distant metastases Present Absent P- value OR 95% CI ANC ≥ 6000 97 (39%) 154 (61%) 0.024 0.65 (0.4-0.9) ANC < 6000 73 (29%) 178 (71%) ALC ≥ 2000 83 (33%) 168 (67%) 0.7 1.0 (0.7-1.6) ALC < 2000 87 (34%) 164 (66%) AMC ≥ 660 92 (37%) 159 (63%) 0.19 0.8 (0.5-1.1) AMC < 660 78(31%) 173 (69%) AEC ≥ 215 98(67.6%) 151 (61%) 0.001 0.5 (0.3-0.8) AEC < 215 47(25%) 142 (75%) NLR ≥ 3.9 86 (44%) 110 (56%) 0.0001 0.5 (0.3-0.7) NLR< 3.9 84 (27%) 222 (73%) MLR ≥ 0.3 89 (35%) 162 (65%) 0.45 0.9 (0.6-1.3) MLR< 0.3 81(32%) 170 (68%) PLR ≥ 0.15 98 (40%) 150 (60%) 0.001 0.5 (0.3-0.8) PLR < 0.15 57 (25%) 171 (75%)" @default.
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- W4316084807 date "2022-10-01" @default.
- W4316084807 modified "2023-09-26" @default.
- W4316084807 title "S1586 Prognostic Value of Systemic Inflammatory Markers in Patients With Gastric Adenocarcinoma" @default.
- W4316084807 doi "https://doi.org/10.14309/01.ajg.0000862984.77060.15" @default.
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