Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316085778> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4316085778 endingPage "e1812" @default.
- W4316085778 startingPage "e1812" @default.
- W4316085778 abstract "Introduction: Crohn’s Disease (CD) is a chronic idiopathic inflammatory bowel disease with variable clinical and histologic manifestations. Microscopic findings include transmural inflammation and may show granuloma in a subset of patients. The impact of extraintestinal granulomatous inflammation in CD is not well understood. We present an atypical initial presentation of CD in the form of diffuse granulomatous mesenteric adenitis. Case Description/Methods: A 31-year-old woman with ampiginous choroiditis presented with a month of diffuse abdominal pain and fever. Computed tomography (CT) of the abdomen/pelvis showed diffuse mesenteric lymph node enlargement with normal appearing bowels. Given her fevers, lymphadenopathy, mild leukocytosis, and elevation in inflammatory markers, thorough infectious and rheumatologic workups were pursued and unrevealing. Whole body positron emission tomography showed hypermetabolic mesenteric lymph nodes and terminal ileitis; subsequent colonoscopy noted inflamed, friable mucosa with biopsies showing active ileitis, ulceration, architectural distortion, and well-formed intramucosal granuloma consistent with Crohn’s ileitis. CT-guided lymph node biopsy also showed granulomatous inflammation, making sarcoidosis a differential diagnosis. The patient was discharged in stable condition and followed at the outpatient gastroenterology clinic. Given uncertainty regarding the underlying diagnosis, she was trialed on 2 months of budesonide. MRE following treatment showed significantly improved inflammation of the terminal ileum with resolution of mesenteric lymphadenopathy. Discussion: Mesenteric adenitis with terminal ileitis has been shown to occur in infectious ileitis, CD, and sarcoidosis. Rarely, CD can coexist with sarcoidosis. CD has transmural inflammation, with ulceration and granuloma formation, in contrast to intestinal sarcoidosis which only involves the mucosa. Granulomas outside the gastrointestinal tract favor the diagnosis of sarcoidosis but can still occur with CD. In CD, the location of granulomatous inflammation may play a role in predicting clinical course. The presence of mesenteric lymph node (MLN) granulomas has been associated with younger age, transmural inflammation, and postoperative disease recurrence risk. (Figure) Mesenteric granulomatous adenitis without intestinal involvement can be the initial presentation of CD, as noted in our patient. Prompt evaluation of competing diagnoses is warranted to ensure timely diagnosis and management.Figure 1.: A. Computed tomography showing mesenteric haziness and terminal ileitis (red arrow). B. Endoscopic findings of inflamed terminal ileum with congested, erythematous, and ulcerated mucosa." @default.
- W4316085778 created "2023-01-14" @default.
- W4316085778 creator A5008987683 @default.
- W4316085778 creator A5014062369 @default.
- W4316085778 creator A5054199661 @default.
- W4316085778 creator A5085948854 @default.
- W4316085778 date "2022-10-01" @default.
- W4316085778 modified "2023-09-27" @default.
- W4316085778 title "S2761 Crohn's Disease Presenting as Diffuse Granulomatous Mesenteric Adenitis" @default.
- W4316085778 doi "https://doi.org/10.14309/01.ajg.0000867684.43928.b2" @default.
- W4316085778 hasPublicationYear "2022" @default.
- W4316085778 type Work @default.
- W4316085778 citedByCount "0" @default.
- W4316085778 crossrefType "journal-article" @default.
- W4316085778 hasAuthorship W4316085778A5008987683 @default.
- W4316085778 hasAuthorship W4316085778A5014062369 @default.
- W4316085778 hasAuthorship W4316085778A5054199661 @default.
- W4316085778 hasAuthorship W4316085778A5085948854 @default.
- W4316085778 hasBestOaLocation W43160857781 @default.
- W4316085778 hasConcept C126322002 @default.
- W4316085778 hasConcept C142724271 @default.
- W4316085778 hasConcept C2778923028 @default.
- W4316085778 hasConcept C2779134260 @default.
- W4316085778 hasConcept C2779280984 @default.
- W4316085778 hasConcept C2780140890 @default.
- W4316085778 hasConcept C2780941987 @default.
- W4316085778 hasConcept C2781301800 @default.
- W4316085778 hasConcept C71924100 @default.
- W4316085778 hasConcept C90924648 @default.
- W4316085778 hasConceptScore W4316085778C126322002 @default.
- W4316085778 hasConceptScore W4316085778C142724271 @default.
- W4316085778 hasConceptScore W4316085778C2778923028 @default.
- W4316085778 hasConceptScore W4316085778C2779134260 @default.
- W4316085778 hasConceptScore W4316085778C2779280984 @default.
- W4316085778 hasConceptScore W4316085778C2780140890 @default.
- W4316085778 hasConceptScore W4316085778C2780941987 @default.
- W4316085778 hasConceptScore W4316085778C2781301800 @default.
- W4316085778 hasConceptScore W4316085778C71924100 @default.
- W4316085778 hasConceptScore W4316085778C90924648 @default.
- W4316085778 hasIssue "10S" @default.
- W4316085778 hasLocation W43160857781 @default.
- W4316085778 hasLocation W43160857782 @default.
- W4316085778 hasOpenAccess W4316085778 @default.
- W4316085778 hasPrimaryLocation W43160857781 @default.
- W4316085778 hasRelatedWork W2102199574 @default.
- W4316085778 hasRelatedWork W2131386362 @default.
- W4316085778 hasRelatedWork W2147909272 @default.
- W4316085778 hasRelatedWork W2398273517 @default.
- W4316085778 hasRelatedWork W2550562391 @default.
- W4316085778 hasRelatedWork W2765760981 @default.
- W4316085778 hasRelatedWork W3002688259 @default.
- W4316085778 hasRelatedWork W4205359509 @default.
- W4316085778 hasRelatedWork W4237105610 @default.
- W4316085778 hasRelatedWork W4253387355 @default.
- W4316085778 hasVolume "117" @default.
- W4316085778 isParatext "false" @default.
- W4316085778 isRetracted "false" @default.
- W4316085778 workType "article" @default.