FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316085864> ?p ?o ?g. }

• W4316085864 endingPage "e1781" @default.
• W4316085864 startingPage "e1781" @default.
• W4316085864 abstract "Introduction: Small bowel adenocarcinoma (SBA) accounts for less than 5% of all gastrointestinal malignancies. Crohn's disease (CD) is a well-known risk factor for developing small bowel adenocarcinoma. CD-associated small bowel adenocarcinoma tends to develop at a younger age, mainly involves distal jejunum and terminal ileum, and is male predominant. SBA in the setting of CD is incidentally found after surgical resection. We present a rare case of small bowel adenocarcinoma as the first manifestation of Crohn's disease in a patient with a history of celiac disease. Case Description/Methods: We present a 35-year-old female with a remote history of biopsy proven celiac disease and a history of multiple small bowel strictures dating back to the age of 16, which was thought to be due to ulcerative jejunitis. She never underwent an exploratory laparoscopy for tissue diagnosis. She was placed on a gluten-free diet with improvement in her symptoms. She presented to our clinic with episodes of nausea and vomiting that started five years ago. Labs done at that time were unremarkable except for mildly elevated fecal calprotectin. CT scan abdomen pelvis showed multiple strictures throughout the small bowel, including the proximal jejunum. Colonoscopy with terminal ileal biopsy was normal. She was then seen by surgery and underwent an exploratory laparoscopy with resection of two small bowel strictures and stricturoplasty of the other two strictures. Pathology showed active jejunitis and non-necrotizing granulomas consistent with Crohn's disease and findings of well differentiated mucinous adenocarcinoma in the first stricture and moderate to poorly differentiated adenocarcinoma in the second stricture. She was staged to be T2 N0 MX. She was started on adalimumab and has been on remission. (Figure) Discussion: Our case is unusual in that there are very few reported cases of SBA in undiagnosed CD. Data concerning SBA in CD is based on case reports, small retrospective series and literature reviews. SBA in CDs strictures poses a diagnostic challenge as it is difficult to differentiate a malignant stricture from an inflammatory stricture using conventional investigation modalities. As such, it is essential for surgeons to maintain a high index of suspicion for occult SBA and careful investigation with frozen section and/or resection for suspicious findings. Also, our case is exceptional as the diagnosis of inflammatory bowel disease could not be established at the time when the patient sought medical care.Figure 1.: A) Non-caseating granuloma of regional lymph node (400x), B) Cryptitis and crypt abscess (400x). C) Moderately to poorly differentiated adenocarcinoma with desmoplastic stromal response within jejunal stricture site (100x)." @default.
• W4316085864 created "2023-01-14" @default.
• W4316085864 creator A5001353777 @default.
• W4316085864 creator A5029001144 @default.
• W4316085864 creator A5054797951 @default.
• W4316085864 creator A5058614177 @default.
• W4316085864 creator A5065617678 @default.
• W4316085864 date "2022-10-01" @default.
• W4316085864 modified "2023-09-27" @default.
• W4316085864 title "S2703 Multifocal Small Bowel Adenocarcinoma as Primary Presentation of Crohn's Disease in a Patient With a Remote History of Celiac Disease" @default.
• W4316085864 doi "https://doi.org/10.14309/01.ajg.0000867452.24093.62" @default.
• W4316085864 hasPublicationYear "2022" @default.
• W4316085864 type Work @default.
• W4316085864 citedByCount "0" @default.
• W4316085864 crossrefType "journal-article" @default.
• W4316085864 hasAuthorship W4316085864A5001353777 @default.
• W4316085864 hasAuthorship W4316085864A5029001144 @default.
• W4316085864 hasAuthorship W4316085864A5054797951 @default.
• W4316085864 hasAuthorship W4316085864A5058614177 @default.
• W4316085864 hasAuthorship W4316085864A5065617678 @default.
• W4316085864 hasBestOaLocation W43160858641 @default.
• W4316085864 hasConcept C121608353 @default.
• W4316085864 hasConcept C126322002 @default.
• W4316085864 hasConcept C2775934546 @default.
• W4316085864 hasConcept C2778260677 @default.
• W4316085864 hasConcept C2778435480 @default.
• W4316085864 hasConcept C2778451229 @default.
• W4316085864 hasConcept C2779134260 @default.
• W4316085864 hasConcept C2779280984 @default.
• W4316085864 hasConcept C2780970106 @default.
• W4316085864 hasConcept C2781179581 @default.
• W4316085864 hasConcept C2781182431 @default.
• W4316085864 hasConcept C526805850 @default.
• W4316085864 hasConcept C71924100 @default.
• W4316085864 hasConcept C90924648 @default.
• W4316085864 hasConceptScore W4316085864C121608353 @default.
• W4316085864 hasConceptScore W4316085864C126322002 @default.
• W4316085864 hasConceptScore W4316085864C2775934546 @default.
• W4316085864 hasConceptScore W4316085864C2778260677 @default.
• W4316085864 hasConceptScore W4316085864C2778435480 @default.
• W4316085864 hasConceptScore W4316085864C2778451229 @default.
• W4316085864 hasConceptScore W4316085864C2779134260 @default.
• W4316085864 hasConceptScore W4316085864C2779280984 @default.
• W4316085864 hasConceptScore W4316085864C2780970106 @default.
• W4316085864 hasConceptScore W4316085864C2781179581 @default.
• W4316085864 hasConceptScore W4316085864C2781182431 @default.
• W4316085864 hasConceptScore W4316085864C526805850 @default.
• W4316085864 hasConceptScore W4316085864C71924100 @default.
• W4316085864 hasConceptScore W4316085864C90924648 @default.
• W4316085864 hasIssue "10S" @default.
• W4316085864 hasLocation W43160858641 @default.
• W4316085864 hasLocation W43160858642 @default.
• W4316085864 hasOpenAccess W4316085864 @default.
• W4316085864 hasPrimaryLocation W43160858641 @default.
• W4316085864 hasRelatedWork W1975032444 @default.
• W4316085864 hasRelatedWork W2024216943 @default.
• W4316085864 hasRelatedWork W2077331089 @default.
• W4316085864 hasRelatedWork W2077443323 @default.
• W4316085864 hasRelatedWork W2090292636 @default.
• W4316085864 hasRelatedWork W2786161279 @default.
• W4316085864 hasRelatedWork W2963825579 @default.
• W4316085864 hasRelatedWork W4207040206 @default.
• W4316085864 hasRelatedWork W4212847486 @default.
• W4316085864 hasRelatedWork W4214490500 @default.
• W4316085864 hasVolume "117" @default.
• W4316085864 isParatext "false" @default.
• W4316085864 isRetracted "false" @default.
• W4316085864 workType "article" @default.