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• W4316086705 abstract "Introduction: Esophageal malignancies usually present with dysphagia and unintentional weight loss. Other symptoms include regurgitation, aspiration events or cough, and voice changes from invasion of adjacent structures. Paraneoplastic syndromes are a rare sequela of esophageal adenocarcinoma. Case Description/Methods: A 76-year-old male with a history of colorectal cancer in remission, who was diagnosed with periorbital cellulitis and treated with antibiotics, presented a few months later with symptom progression. He reported facial swelling, dysphagia, odynophagia, painful oral ulcers and diffuse arthralgias. Labs revealed total bilirubin of 1.8, ALP 92, AST 270, ALT 63, ANA 1:640, ESR 10, CRP 112, Ferritin 635 and normal C3, C4 levels. Scl-Antibody, Rheumatoid factor, HIV and Monospot tests were negative. EGD showed mild esophagitis and benign-appearing stenosis. He was discharged on a prednisone course. A month later, his symptoms continued to progressively worsen and finally a diagnosis of vocal cord asymmetry led to re-admission. On exam, Gottron’s papules were found. Labs showed high CK levels and muscle biopsy confirmed dermatomyositis. CT scan revealed thickening of distal esophagus. Esophageal adenocarcinoma was diagnosed by distal esophageal nodule biopsy on a second EGD (Figure 1A). Subsequent EUS showed the lesion extending to the submucosa (Figure 1B). Dermatomyositis was attributed to paraneoplastic syndrome in the setting of the malignancy. The paraneoplastic syndrome was initially treated by IVIG and IV steroids. He subsequently underwent esophagectomy and chemotherapy with cisplatin and 5-FU. Discussion: Inflammatory myopathies, especially dermatomyositis, may develop in the setting of malignancy. Gastric, cervical, ovarian, lung, and pancreatic adenocarcinomas are common in patients with inflammatory myopathy. However, esophageal adenocarcinomas rarely present with dermatomyositis. Dysphagia is associated with esophageal malignancy, but when dermatomyositis is recognized first, dysphagia may be attributed to upper esophageal and oropharyngeal muscles weakness, leading to delayed diagnosis. Clinicians need to have high suspicion in such cases. Even though no guidelines exist, patients with new onset dermatomyositis need investigation for underlying malignancy. Dysphagia, older age, evidence of capillary damage on muscle biopsy and cutaneous necrosis in the setting of dermatomyositis are factors associated with underlying malignancy. As such, these patients need timely diagnostic work-up.Figure 1.: A: Nodularity seen in lower esophagus; B: EUS findings." @default.
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• W4316086705 date "2022-10-01" @default.
• W4316086705 modified "2023-09-27" @default.
• W4316086705 title "S2309 Esophageal Adenocarcinoma Causing Paraneoplastic Dermatomyositis: Preventing Delayed Diagnosis Is Key" @default.
• W4316086705 doi "https://doi.org/10.14309/01.ajg.0000865876.14563.27" @default.
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