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• W4316096987 abstract "Streptococcus bovis/equinus complex (SBEC) is a major cause of infective endocarditis (IE), although its incidence varies greatly depending on the geographical area. The characteristics of IE caused by Streptococcus gallolyticus susp. gallolyticus are well known; there are hardly any descriptions of IE caused by other species or biotypes.Retrospective cohort study, from 1990 to 2019, of all SBEC IE in adults in three Spanish hospitals, Lugo (LH), Barcelona (BH) and Ferrol (FH) where the population is mainly rural, urban and mixed, respectively. The incidence of IE was analyzed in 3 areas. Clinical characteristics of IE (277 cases, 258 biotyped) were compared according to SBEC species and biotypes.There are significant differences between the incidence of SBEC IE in HL (27.9/106) vs. HF and HB (8.8 and 7,1, respectively, p < 0.001). We found significant differences (SbI vs. SbII) in mean age (68.5 vs. 73 years; p < 0.01), duration of symptoms before diagnosis (46.9 ± 46.5 vs. 30.4 ± 40.9 days; p < 0.01), presence of comorbidities: 39.1% (78) vs. 54.2% (32; p < 0.04), predisposing heart illness:62.3% (124) vs. 81.3% (48; p < 0.006), particularly, prosthetic or intravascular devices IE: 24.6% (49) vs. 52.4% (31; p < 0.001), bi-valve involvement:23.6% (47) vs. 11.8% (7; p < 0.05) and heart failure: 24.6% (49) vs. 38.9% (23; p < 0.03). There were no significant differences in embolic events, need for surgery or mortality. The association with CRC was high in both groups: 77.7% vs. 66.6%.IE due to SBEC has geographical variations in incidence and different clinical characteristics among biotypes. The association with CRC was high.El complejo Streptococcus bovis/equinus (SBEC) es una de las principales causas de endocarditis infecciosa (EI), aunque su incidencia es muy variable según la zona geográfica. Las características de EI causada por Streptococcus gallolyticus subsp. gallolyticus son bien conocidas; apenas hay descripciones de EI causada por otras especies o biotipos.Estudio de cohorte retrospectivo, desde 1990 hasta 2019, de todas las EI por SBEC en adultos en 3 hospitales españoles, Lugo (LH), Barcelona (BH) y Ferrol (FH) donde la población es mayoritariamente rural, urbana y mixta, respectivamente. Se analizó la incidencia de EI en 3 áreas. Se compararon las características clínicas de EI (277 casos, 258 biotipados) según las especies y biotipos de SBEC.Existen diferencias significativas entre la incidencia de EI por SBEC en HL (27,9/106) vs. HF y HB (8,8 y 7,1, respectivamente, p < 0,001). Encontramos diferencias significativas (SbI vs. SbII) en edad media (68,5 vs. 73 años; p < 0,01), duración de los síntomas antes del diagnóstico (46,9 ± 46,5 vs. 30,4 ± 40,9 días; p < 0,01); comorbilidades: 39,1 (78) vs. 54,2% (32; p < 0,04); enfermedad cardíaca predisponente: 62,3 (124) vs. 81,3% (48; p < 0,006), en particular, EI protésica o sobre dispositivos intravasculares: 24,6 (49) vs. 52,4% (31; p < 0,001); afectación bivalva: 23,6 (47) vs. 11,8% (7; p < 0,05) e insuficiencia cardiaca: 24,6 (49) vs. 38,9% (23; p < 0,03). No hubo diferencias significativas en cuanto a eventos embólicos, necesidad de cirugía o mortalidad. La asociación con el CCR fue alta en ambos grupos: 77,7 vs. 66,6%.La EI por SBEC tiene variaciones geográficas en la incidencia y diferentes características clínicas entre los biotipos. La asociación con el CCR fue elevada." @default.
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• W4316096987 date "2023-05-01" @default.
• W4316096987 modified "2023-10-18" @default.
• W4316096987 title "Anisocoria and optic neuritis associated with Mycoplasma pneumoniae infection" @default.
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• W4316096987 doi "https://doi.org/10.1016/j.eimce.2023.01.001" @default.
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