Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316126949> ?p ?o ?g. }
- W4316126949 endingPage "104837" @default.
- W4316126949 startingPage "104837" @default.
- W4316126949 abstract "General structure of metabolism includes the reproduction of catalysts that govern metabolism. In this structure, the system becomes autopoietic in the sense of Maturana and Varela, and it is closed to efficient causation as defined by Robert Rosen. The autopoietic maintenance and operation of the catalysts takes place via the set of free nucleotides while the synthesis of catalysts occurs via the information encoded by the set of nucleotides arranged in polymers of RNA and DNA. Both energy charge and genetic information use the components of the same pool of nucleoside triphosphates, which is equilibrated by thermodynamic buffering enzymes such as nucleoside diphosphate kinase and adenylate kinase. This occurs in a way that the system becomes internally stable and metabolically closed, which initially could be realized at the level of ribozymes catalyzing basic metabolic reactions as well as own reproduction. The function of ATP, GTP, UTP, and CTP is dual, as these species participate both in the general metabolism as free nucleotides and in the transfer of genetic information via covalent polymerization to nucleic acids. The changes in their pools directly impact both bioenergetic pathways and nucleic acid turnover. Here we outline the concept of metabolic closure of biosystems grounded in the dual function of nucleotide coenzymes that serve both as energetic and informational molecules and through this duality generate the autopoietic performance and the ability for codepoietic evolutionary transformations of living systems starting from the emergence of prebiotic systems." @default.
- W4316126949 created "2023-01-14" @default.
- W4316126949 creator A5012989382 @default.
- W4316126949 creator A5014814187 @default.
- W4316126949 date "2023-02-01" @default.
- W4316126949 modified "2023-10-05" @default.
- W4316126949 title "Toward understanding the emergence of life: A dual function of the system of nucleotides in the metabolically closed autopoietic organization" @default.
- W4316126949 cites W142433902 @default.
- W4316126949 cites W1497143641 @default.
- W4316126949 cites W1538613429 @default.
- W4316126949 cites W1612553237 @default.
- W4316126949 cites W1633944576 @default.
- W4316126949 cites W1765868291 @default.
- W4316126949 cites W1879750355 @default.
- W4316126949 cites W1966937146 @default.
- W4316126949 cites W1967830783 @default.
- W4316126949 cites W1967910812 @default.
- W4316126949 cites W1977654774 @default.
- W4316126949 cites W1982214427 @default.
- W4316126949 cites W1983744996 @default.
- W4316126949 cites W1988349747 @default.
- W4316126949 cites W1993215186 @default.
- W4316126949 cites W1995639982 @default.
- W4316126949 cites W1995699286 @default.
- W4316126949 cites W1996504243 @default.
- W4316126949 cites W1996955056 @default.
- W4316126949 cites W1997503948 @default.
- W4316126949 cites W2003570650 @default.
- W4316126949 cites W2010780485 @default.
- W4316126949 cites W2013295580 @default.
- W4316126949 cites W2017100707 @default.
- W4316126949 cites W2020179368 @default.
- W4316126949 cites W2020454825 @default.
- W4316126949 cites W2029032392 @default.
- W4316126949 cites W2033046940 @default.
- W4316126949 cites W2034906618 @default.
- W4316126949 cites W2037238732 @default.
- W4316126949 cites W2040746730 @default.
- W4316126949 cites W2044217069 @default.
- W4316126949 cites W2044773108 @default.
- W4316126949 cites W2047348552 @default.
- W4316126949 cites W2047589262 @default.
- W4316126949 cites W2050641111 @default.
- W4316126949 cites W2055145209 @default.
- W4316126949 cites W2057319400 @default.
- W4316126949 cites W2060887865 @default.
- W4316126949 cites W2066977571 @default.
- W4316126949 cites W2072342699 @default.
- W4316126949 cites W2075152880 @default.
- W4316126949 cites W2076002927 @default.
- W4316126949 cites W2077866448 @default.
- W4316126949 cites W2080400852 @default.
- W4316126949 cites W2089581365 @default.
- W4316126949 cites W2090821289 @default.
- W4316126949 cites W2109769274 @default.
- W4316126949 cites W2125016577 @default.
- W4316126949 cites W2127728780 @default.
- W4316126949 cites W2128053736 @default.
- W4316126949 cites W2128325532 @default.
- W4316126949 cites W2128646490 @default.
- W4316126949 cites W2134740632 @default.
- W4316126949 cites W2137186514 @default.
- W4316126949 cites W2152851259 @default.
- W4316126949 cites W2165966788 @default.
- W4316126949 cites W2169672447 @default.
- W4316126949 cites W2173023892 @default.
- W4316126949 cites W2183397565 @default.
- W4316126949 cites W2288856974 @default.
- W4316126949 cites W2298208569 @default.
- W4316126949 cites W2504528850 @default.
- W4316126949 cites W2515842261 @default.
- W4316126949 cites W2751122156 @default.
- W4316126949 cites W2754230492 @default.
- W4316126949 cites W2761628874 @default.
- W4316126949 cites W2901888254 @default.
- W4316126949 cites W2938632665 @default.
- W4316126949 cites W2943510327 @default.
- W4316126949 cites W2950533721 @default.
- W4316126949 cites W2966510906 @default.
- W4316126949 cites W2984829254 @default.
- W4316126949 cites W3002842627 @default.
- W4316126949 cites W3087824152 @default.
- W4316126949 cites W3108271252 @default.
- W4316126949 cites W3118123444 @default.
- W4316126949 cites W3124996935 @default.
- W4316126949 cites W3127613891 @default.
- W4316126949 cites W3132313371 @default.
- W4316126949 cites W3134451727 @default.
- W4316126949 cites W3139169054 @default.
- W4316126949 cites W3155006166 @default.
- W4316126949 cites W3157579223 @default.
- W4316126949 cites W3163162395 @default.
- W4316126949 cites W3171803253 @default.
- W4316126949 cites W3173432174 @default.
- W4316126949 cites W3199375492 @default.
- W4316126949 cites W3200774610 @default.
- W4316126949 cites W4220933091 @default.
- W4316126949 cites W4239317064 @default.