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- W4316171106 endingPage "216066" @default.
- W4316171106 startingPage "216066" @default.
- W4316171106 abstract "Metastasis accounts for greater than 90% of cancer-related deaths. Despite recent advancements in conventional chemotherapy, immunotherapy, targeted therapy, and their rational combinations, metastatic cancers remain essentially untreatable. The distinct obstacles to treat metastases include their small size, high multiplicity, redundancy, therapeutic resistance, and dissemination to multiple organs. Recent advancements in nanotechnology provide the numerous applications in the diagnosis and prophylaxis of metastatic diseases, including the small particle size to penetrate cell membrane and blood vessels and their capacity to transport complex molecular ‘cargo’ particles to various metastatic regions such as bones, brain, liver, lungs, and lymph nodes. Indeed, nanoparticles (NPs) have demonstrated a significant ability to target specific cells within these organs. In this regard, the purpose of this review is to summarize the present state of nanotechnology in terms of its application in the diagnosis and treatment of metastatic cancer. We intensively reviewed applications of NPs in fluorescent imaging, PET scanning, MRI, and photoacoustic imaging to detect metastasis in various cancer models. The use of targeted NPs for cancer ablation in conjunction with chemotherapy, photothermal treatment, immuno therapy, and combination therapy is thoroughly discussed. The current review also highlights the research opportunities and challenges of leveraging engineering technologies with cancer cell biology and pharmacology to fabricate nanoscience-based tools for treating metastases." @default.
- W4316171106 created "2023-01-15" @default.
- W4316171106 creator A5003289370 @default.
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- W4316171106 creator A5046537118 @default.
- W4316171106 creator A5067105308 @default.
- W4316171106 creator A5080676400 @default.
- W4316171106 creator A5091586896 @default.
- W4316171106 date "2023-03-01" @default.
- W4316171106 modified "2023-10-18" @default.
- W4316171106 title "Nanoparticles in the diagnosis and treatment of cancer metastases: Current and future perspectives" @default.
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