FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316174265> ?p ?o ?g. }

• W4316174265 abstract "Genetic networks are surprisingly robust to perturbations caused by new mutations. This robustness is conferred in part by compensation for loss of a gene's activity by genes with overlapping functions, such as paralogs. Compensation occurs passively when the normal activity of one paralog can compensate for the loss of the other, or actively when a change in one paralog's expression, localization, or activity is required to compensate for loss of the other. The mechanisms of active compensation remain poorly understood in most cases. Here we investigate active compensation for the loss or reduction in expression of the Saccharomyces cerevisiae gene TDH3 by its paralogs TDH1 and TDH2. TDH1 and TDH2 are upregulated in a dose-dependent manner in response to reductions in TDH3 by a mechanism requiring the shared transcriptional regulators Gcr1p and Rap1p. Other glycolytic genes regulated by Rap1p and Gcr1p show changes in expression similar to TDH2 , suggesting that the active compensation by TDH3 paralogs is part of a broader homeostatic response mediated by shared transcriptional regulators." @default.
• W4316174265 created "2023-01-15" @default.
• W4316174265 creator A5026420322 @default.
• W4316174265 creator A5033807850 @default.
• W4316174265 date "2023-01-14" @default.
• W4316174265 modified "2023-10-17" @default.
• W4316174265 title "Active compensation for changes in<i>TDH3</i>expression mediated by direct regulators of<i>TDH3</i>in<i>Saccharomyces cerevisiae</i>" @default.
• W4316174265 cites W1534101457 @default.
• W4316174265 cites W1542395301 @default.
• W4316174265 cites W1548262973 @default.
• W4316174265 cites W1552702611 @default.
• W4316174265 cites W1566143784 @default.
• W4316174265 cites W1579430094 @default.
• W4316174265 cites W1587039134 @default.
• W4316174265 cites W1644724366 @default.
• W4316174265 cites W1773018645 @default.
• W4316174265 cites W1964998867 @default.
• W4316174265 cites W1971577828 @default.
• W4316174265 cites W1976445111 @default.
• W4316174265 cites W1977848450 @default.
• W4316174265 cites W1979483810 @default.
• W4316174265 cites W1989424254 @default.
• W4316174265 cites W1991170638 @default.
• W4316174265 cites W1999880514 @default.
• W4316174265 cites W2002701055 @default.
• W4316174265 cites W2008226163 @default.
• W4316174265 cites W2013034131 @default.
• W4316174265 cites W2018108454 @default.
• W4316174265 cites W2022589976 @default.
• W4316174265 cites W2023432555 @default.
• W4316174265 cites W2028110618 @default.
• W4316174265 cites W2036503152 @default.
• W4316174265 cites W2040559041 @default.
• W4316174265 cites W2043093337 @default.
• W4316174265 cites W2046449536 @default.
• W4316174265 cites W2062195139 @default.
• W4316174265 cites W2077941487 @default.
• W4316174265 cites W2100167673 @default.
• W4316174265 cites W2105480322 @default.
• W4316174265 cites W2121477676 @default.
• W4316174265 cites W2132757418 @default.
• W4316174265 cites W2133102806 @default.
• W4316174265 cites W2133422502 @default.
• W4316174265 cites W2142437744 @default.
• W4316174265 cites W2144688273 @default.
• W4316174265 cites W2146484977 @default.
• W4316174265 cites W2146551586 @default.
• W4316174265 cites W2147555013 @default.
• W4316174265 cites W2148726194 @default.
• W4316174265 cites W2155320896 @default.
• W4316174265 cites W2163003877 @default.
• W4316174265 cites W2164791361 @default.
• W4316174265 cites W2168365185 @default.
• W4316174265 cites W2179438025 @default.
• W4316174265 cites W2229860479 @default.
• W4316174265 cites W2346917851 @default.
• W4316174265 cites W2620771580 @default.
• W4316174265 cites W2784228679 @default.
• W4316174265 cites W2938511997 @default.
• W4316174265 cites W2952730289 @default.
• W4316174265 cites W2952817404 @default.
• W4316174265 cites W3037808763 @default.
• W4316174265 cites W3081982717 @default.
• W4316174265 cites W3097825150 @default.
• W4316174265 cites W3183866371 @default.
• W4316174265 cites W3197881596 @default.
• W4316174265 cites W4233068112 @default.
• W4316174265 cites W4283731821 @default.
• W4316174265 doi "https://doi.org/10.1101/2023.01.13.523977" @default.
• W4316174265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36711763" @default.
• W4316174265 hasPublicationYear "2023" @default.
• W4316174265 type Work @default.
• W4316174265 citedByCount "0" @default.
• W4316174265 crossrefType "posted-content" @default.
• W4316174265 hasAuthorship W4316174265A5026420322 @default.
• W4316174265 hasAuthorship W4316174265A5033807850 @default.
• W4316174265 hasBestOaLocation W43161742651 @default.
• W4316174265 hasConcept C104317684 @default.
• W4316174265 hasConcept C11171543 @default.
• W4316174265 hasConcept C127561419 @default.
• W4316174265 hasConcept C150194340 @default.
• W4316174265 hasConcept C15744967 @default.
• W4316174265 hasConcept C165864922 @default.
• W4316174265 hasConcept C186310378 @default.
• W4316174265 hasConcept C2777576037 @default.
• W4316174265 hasConcept C2780023022 @default.
• W4316174265 hasConcept C54355233 @default.
• W4316174265 hasConcept C63479239 @default.
• W4316174265 hasConcept C86803240 @default.
• W4316174265 hasConcept C95444343 @default.
• W4316174265 hasConceptScore W4316174265C104317684 @default.
• W4316174265 hasConceptScore W4316174265C11171543 @default.
• W4316174265 hasConceptScore W4316174265C127561419 @default.
• W4316174265 hasConceptScore W4316174265C150194340 @default.
• W4316174265 hasConceptScore W4316174265C15744967 @default.
• W4316174265 hasConceptScore W4316174265C165864922 @default.
• W4316174265 hasConceptScore W4316174265C186310378 @default.
• W4316174265 hasConceptScore W4316174265C2777576037 @default.
• W4316174265 hasConceptScore W4316174265C2780023022 @default.
• W4316174265 hasConceptScore W4316174265C54355233 @default.

• next