Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316259488> ?p ?o ?g. }
- W4316259488 abstract "ABSTRACT The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear memory updating remain poorly understood. Postsynaptic density protein 95 (PSD-95) regulates the structure and function of glutamatergic synapses. Here, using dCA1-targeted genetic manipulations in vivo , combined with ex vivo 3D electron microscopy and electrophysiology, we identify a novel, synaptic mechanism that is induced during attenuation of contextual fear memories and involves phosphorylation of PSD-95 at Serine 73 in dCA1. Our data provide the proof that PSD-95-dependent synaptic plasticity in dCA1 is required for updating of contextual fear memory." @default.
- W4316259488 created "2023-01-15" @default.
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- W4316259488 date "2023-01-15" @default.
- W4316259488 modified "2023-10-17" @default.
- W4316259488 title "Phosphorylation of PSD-95 at Serine 73 in dCA1 is required for extinction of contextual fear" @default.
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- W4316259488 doi "https://doi.org/10.1101/2023.01.11.523603" @default.
- W4316259488 hasPublicationYear "2023" @default.