FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316339991> ?p ?o ?g. }

• W4316339991 endingPage "114540" @default.
• W4316339991 startingPage "114540" @default.
• W4316339991 abstract "Pesticides could induce long-term impacts on aquatic ecosystem via transgenerational toxicity. However, for many chiral pesticides, the potential enantioselectivity of transgenerational toxicity has yet to be fully understood. In this study, we used zebrafish as models to evaluate the maternal transfer risk of tebuconazole (TEB), which is a chiral triazole fungicide currently used worldwide and has been frequently detected in surface waters. After 28-day food exposure (20 and 400 ng/g) to the two enantiomers of TEB (S- and R-TEB) in adult female zebrafish (F0), increased malformation rate and decreased swimming speed were found in F1 larvae, with R-TEB showing higher impacts than S-enantiomer. Additionally, enantioselective effects on the secretion of thyroid hormones (THs) and expression of TH-related key genes along the hypothalamic-pituitary-thyroid (HPT) axis were found in both F0 and F1 after maternal exposure. Both the two enantiomers significantly disrupted the triiodothyronine (T3) and thyroxine (T4) contents in F0 with different degrees, whereas in F1, significant effects were only found in R-TEB groups with decreasing of both T3 and T4 contents. Most of the HPT axis related genes in F0 were upregulated by TEB and more sensitive to R-TEB than to S-TEB. In contrast, most of the genes in F1 were downregulated by both R- and S-TEB, especially the genes that are primarily responsible for thyroid development and growth (Nkx2-1), TH synthesis (NIS and TSHꞵ) and metabolism (Deio1). Findings from this study highlight the key role of enantioselectivity in the ecological risk assessment of chiral pesticides through maternal transfer." @default.
• W4316339991 created "2023-01-16" @default.
• W4316339991 creator A5006094386 @default.
• W4316339991 creator A5013342266 @default.
• W4316339991 creator A5021277858 @default.
• W4316339991 creator A5023344661 @default.
• W4316339991 creator A5031722471 @default.
• W4316339991 creator A5032593123 @default.
• W4316339991 creator A5053402822 @default.
• W4316339991 creator A5071509336 @default.
• W4316339991 creator A5078873671 @default.
• W4316339991 creator A5082535541 @default.
• W4316339991 date "2023-02-01" @default.
• W4316339991 modified "2023-09-26" @default.
• W4316339991 title "Maternal exposure to chiral triazole fungicide tebuconazole induces enantioselective thyroid disruption in zebrafish offspring" @default.
• W4316339991 cites W1977063410 @default.
• W4316339991 cites W1979124444 @default.
• W4316339991 cites W1981942539 @default.
• W4316339991 cites W1990935649 @default.
• W4316339991 cites W1999931553 @default.
• W4316339991 cites W2013775060 @default.
• W4316339991 cites W2019106047 @default.
• W4316339991 cites W2022680630 @default.
• W4316339991 cites W2023236773 @default.
• W4316339991 cites W2025783042 @default.
• W4316339991 cites W2026307205 @default.
• W4316339991 cites W2033207810 @default.
• W4316339991 cites W2039875568 @default.
• W4316339991 cites W2040194132 @default.
• W4316339991 cites W2047554933 @default.
• W4316339991 cites W2051786885 @default.
• W4316339991 cites W2063014227 @default.
• W4316339991 cites W2072657555 @default.
• W4316339991 cites W2078204063 @default.
• W4316339991 cites W2083789451 @default.
• W4316339991 cites W2089164938 @default.
• W4316339991 cites W2091189726 @default.
• W4316339991 cites W2098597135 @default.
• W4316339991 cites W2107277218 @default.
• W4316339991 cites W2152435679 @default.
• W4316339991 cites W2202986250 @default.
• W4316339991 cites W2292461613 @default.
• W4316339991 cites W2593455227 @default.
• W4316339991 cites W2604929762 @default.
• W4316339991 cites W2624005088 @default.
• W4316339991 cites W2758897529 @default.
• W4316339991 cites W2772089939 @default.
• W4316339991 cites W2782391203 @default.
• W4316339991 cites W2783989399 @default.
• W4316339991 cites W2789970929 @default.
• W4316339991 cites W2793401494 @default.
• W4316339991 cites W2810279159 @default.
• W4316339991 cites W2900405367 @default.
• W4316339991 cites W2906718898 @default.
• W4316339991 cites W2906919993 @default.
• W4316339991 cites W2917221023 @default.
• W4316339991 cites W2922506798 @default.
• W4316339991 cites W2933489649 @default.
• W4316339991 cites W349739164 @default.
• W4316339991 doi "https://doi.org/10.1016/j.ecoenv.2023.114540" @default.
• W4316339991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640570" @default.
• W4316339991 hasPublicationYear "2023" @default.
• W4316339991 type Work @default.
• W4316339991 citedByCount "1" @default.
• W4316339991 countsByYear W43163399912023 @default.
• W4316339991 crossrefType "journal-article" @default.
• W4316339991 hasAuthorship W4316339991A5006094386 @default.
• W4316339991 hasAuthorship W4316339991A5013342266 @default.
• W4316339991 hasAuthorship W4316339991A5021277858 @default.
• W4316339991 hasAuthorship W4316339991A5023344661 @default.
• W4316339991 hasAuthorship W4316339991A5031722471 @default.
• W4316339991 hasAuthorship W4316339991A5032593123 @default.
• W4316339991 hasAuthorship W4316339991A5053402822 @default.
• W4316339991 hasAuthorship W4316339991A5071509336 @default.
• W4316339991 hasAuthorship W4316339991A5078873671 @default.
• W4316339991 hasAuthorship W4316339991A5082535541 @default.
• W4316339991 hasBestOaLocation W43163399911 @default.
• W4316339991 hasConcept C104317684 @default.
• W4316339991 hasConcept C113214860 @default.
• W4316339991 hasConcept C126322002 @default.
• W4316339991 hasConcept C134018914 @default.
• W4316339991 hasConcept C161176658 @default.
• W4316339991 hasConcept C178790620 @default.
• W4316339991 hasConcept C185592680 @default.
• W4316339991 hasConcept C18903297 @default.
• W4316339991 hasConcept C2776878037 @default.
• W4316339991 hasConcept C2777907353 @default.
• W4316339991 hasConcept C2778288131 @default.
• W4316339991 hasConcept C2780125187 @default.
• W4316339991 hasConcept C29730261 @default.
• W4316339991 hasConcept C486523 @default.
• W4316339991 hasConcept C526584372 @default.
• W4316339991 hasConcept C55493867 @default.
• W4316339991 hasConcept C59822182 @default.
• W4316339991 hasConcept C71240020 @default.
• W4316339991 hasConcept C71315377 @default.
• W4316339991 hasConcept C71924100 @default.
• W4316339991 hasConcept C74600772 @default.

• next