Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316362693> ?p ?o ?g. }
- W4316362693 endingPage "32" @default.
- W4316362693 startingPage "15" @default.
- W4316362693 abstract "Undoubtedly, mesenchymal stem cells (MSCs) are the most common cell therapy candidates in clinical research and therapy. They not only exert considerable therapeutic effects to alleviate inflammation and promote regeneration, but also show low-immunogenicity properties, which ensure their safety following allogeneic transplantation. Thanks to the necessity of providing a sufficient number of MSCs to achieve clinically efficient outcomes, prolonged in vitro cultivation is indisputable. However, either following long-term in vitro expansion or aging in elderly individuals, MSCs face cellular senescence. Senescent MSCs undergo an impairment in their function and therapeutic capacities and secrete degenerative factors which negatively affect young MSCs. To this end, designing novel investigations to further elucidate cellular senescence and to pave the way toward finding new strategies to reverse senescence is highly demanded. In this review, we will concisely discuss current progress on the detailed mechanisms of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on the examined strategies underlying monitoring and reversing senescence in MSCs to bypass the comprised therapeutic efficacy of the senescent MSCs." @default.
- W4316362693 created "2023-01-16" @default.
- W4316362693 creator A5011362931 @default.
- W4316362693 creator A5051594876 @default.
- W4316362693 creator A5068372587 @default.
- W4316362693 creator A5069295016 @default.
- W4316362693 date "2024-01-01" @default.
- W4316362693 modified "2023-10-15" @default.
- W4316362693 title "Age-Related Alterations in Mesenchymal Stem Cell Function: Understanding Mechanisms and Seeking Opportunities to Bypass the Cellular Aging" @default.
- W4316362693 cites W1530824105 @default.
- W4316362693 cites W1554889705 @default.
- W4316362693 cites W1753057509 @default.
- W4316362693 cites W1898024728 @default.
- W4316362693 cites W1936454852 @default.
- W4316362693 cites W1943824439 @default.
- W4316362693 cites W1964120623 @default.
- W4316362693 cites W1964543951 @default.
- W4316362693 cites W1971049798 @default.
- W4316362693 cites W1972002957 @default.
- W4316362693 cites W1977040250 @default.
- W4316362693 cites W1977898454 @default.
- W4316362693 cites W1978174791 @default.
- W4316362693 cites W1980512919 @default.
- W4316362693 cites W1983673827 @default.
- W4316362693 cites W1991554693 @default.
- W4316362693 cites W1992104196 @default.
- W4316362693 cites W1996059719 @default.
- W4316362693 cites W1998461585 @default.
- W4316362693 cites W1999967032 @default.
- W4316362693 cites W2000769293 @default.
- W4316362693 cites W2004294991 @default.
- W4316362693 cites W2005008958 @default.
- W4316362693 cites W2014904868 @default.
- W4316362693 cites W2016037742 @default.
- W4316362693 cites W2024446919 @default.
- W4316362693 cites W2031921408 @default.
- W4316362693 cites W2033855112 @default.
- W4316362693 cites W2035176325 @default.
- W4316362693 cites W2043304304 @default.
- W4316362693 cites W2049446122 @default.
- W4316362693 cites W2050495967 @default.
- W4316362693 cites W2050838528 @default.
- W4316362693 cites W2052004719 @default.
- W4316362693 cites W2053092860 @default.
- W4316362693 cites W2059807701 @default.
- W4316362693 cites W2060134459 @default.
- W4316362693 cites W2060332540 @default.
- W4316362693 cites W2066899457 @default.
- W4316362693 cites W2076972080 @default.
- W4316362693 cites W2077436902 @default.
- W4316362693 cites W2077814461 @default.
- W4316362693 cites W2079983476 @default.
- W4316362693 cites W2083460692 @default.
- W4316362693 cites W2089006877 @default.
- W4316362693 cites W2089878334 @default.
- W4316362693 cites W2090734635 @default.
- W4316362693 cites W2092663592 @default.
- W4316362693 cites W2093586136 @default.
- W4316362693 cites W2095196199 @default.
- W4316362693 cites W2096112724 @default.
- W4316362693 cites W2098586364 @default.
- W4316362693 cites W2102545161 @default.
- W4316362693 cites W2107538726 @default.
- W4316362693 cites W2110535362 @default.
- W4316362693 cites W2113032570 @default.
- W4316362693 cites W2114099339 @default.
- W4316362693 cites W2121709368 @default.
- W4316362693 cites W2126525177 @default.
- W4316362693 cites W2131293951 @default.
- W4316362693 cites W2142804106 @default.
- W4316362693 cites W2145778293 @default.
- W4316362693 cites W2148242495 @default.
- W4316362693 cites W2149507412 @default.
- W4316362693 cites W2157830903 @default.
- W4316362693 cites W2161142016 @default.
- W4316362693 cites W2162057862 @default.
- W4316362693 cites W2162907904 @default.
- W4316362693 cites W2163424015 @default.
- W4316362693 cites W2164397450 @default.
- W4316362693 cites W2166582490 @default.
- W4316362693 cites W2172188068 @default.
- W4316362693 cites W2194928240 @default.
- W4316362693 cites W2225518181 @default.
- W4316362693 cites W2237765743 @default.
- W4316362693 cites W2239690037 @default.
- W4316362693 cites W2339192804 @default.
- W4316362693 cites W2409733755 @default.
- W4316362693 cites W2416051724 @default.
- W4316362693 cites W2463222688 @default.
- W4316362693 cites W2479397168 @default.
- W4316362693 cites W2494515430 @default.
- W4316362693 cites W2556447042 @default.
- W4316362693 cites W2560837503 @default.
- W4316362693 cites W2565449436 @default.
- W4316362693 cites W2565994836 @default.
- W4316362693 cites W2567527198 @default.
- W4316362693 cites W2579192651 @default.
- W4316362693 cites W2581150610 @default.