FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316363079> ?p ?o ?g. }

• W4316363079 abstract "Following the establishment of the anti-cancer effect of immune checkpoint inhibitors, lymphopenia has attracted attention as a parameter of preexisting cancer-related immune tolerance. Although the pretreatment absolute lymphocyte count (ALC) has been reported as a prognostic factor in gastric cancer patients, the impact of perioperative changes in the ALC remains unknown. The aim of the present study was to explore the relationship between surgery-induced lymphopenia and outcome.Database entries for 584 patients who underwent curative resections for pathological Stage IB-III gastric cancer were reviewed. We retrospectively compared clinicopathological factors including pretreatment ALC (pre-ALC) and ALC at first visit after discharge (post-ALC) with the survival. The low ALC was defined as < 1000/μL.The ALC decreased significantly at 1 and 3 days after surgery and then recovered to the baseline value. A low pre-ALC (p < 0.001) and a low post-ALC (p < 0.001) were both correlated with a poor relapse-free survival (RFS). A multivariate analysis of RFS identified a low post-ALC (hazard ratio 1.875, 95% CI 1.156-3.402, p = 0.01), age, gender, BMI, T disease, N disease, severe vessel invasion, type of gastrectomy and postoperative morbidity as independent factors. The low post-ALC group had a poor RFS among patients with Stage II (p = 0.04) and Stage III (p = 0.04) disease, but not among patients with Stage IB disease (p = 0.13). Consistently, the overall survival (OS) rate was significantly lower among patients with a low post-ALC for all stage (p < 0.001), stage II (p = 0.02) and stage III (p = 0.01) disease, not for stage IB (p = 0.09). A low post-ALC was identified as an independent factor for predicting OS by multivariate analysis (hazard ratio: 2.275, 95% CI 1.373-3.769, p = 0.01).A decrease in post-ALC was correlated with both of RFS and OS after curative resection in patients with locally advanced gastric cancer.Postoperative lymphopenia was a poor prognostic factor for gastric cancer." @default.
• W4316363079 created "2023-01-16" @default.
• W4316363079 creator A5000385500 @default.
• W4316363079 creator A5022874036 @default.
• W4316363079 creator A5039432451 @default.
• W4316363079 creator A5067160675 @default.
• W4316363079 creator A5073831136 @default.
• W4316363079 date "2023-01-16" @default.
• W4316363079 modified "2023-09-30" @default.
• W4316363079 title "Predictive significance of surgery-induced lymphopenia on the survival after curative resection for locally advanced gastric cancer: a retrospective cohort analysis" @default.
• W4316363079 cites W1965037168 @default.
• W4316363079 cites W1996668651 @default.
• W4316363079 cites W2026986976 @default.
• W4316363079 cites W2031686271 @default.
• W4316363079 cites W2043432815 @default.
• W4316363079 cites W2047632277 @default.
• W4316363079 cites W2053991659 @default.
• W4316363079 cites W2117692326 @default.
• W4316363079 cites W2123105952 @default.
• W4316363079 cites W2137991416 @default.
• W4316363079 cites W2139448267 @default.
• W4316363079 cites W2143696852 @default.
• W4316363079 cites W2148237316 @default.
• W4316363079 cites W2347070489 @default.
• W4316363079 cites W2386572545 @default.
• W4316363079 cites W2392329487 @default.
• W4316363079 cites W2597618526 @default.
• W4316363079 cites W2607024525 @default.
• W4316363079 cites W2609240810 @default.
• W4316363079 cites W2753951752 @default.
• W4316363079 cites W2763064222 @default.
• W4316363079 cites W2772599579 @default.
• W4316363079 cites W2792863333 @default.
• W4316363079 cites W2793364080 @default.
• W4316363079 cites W2797011267 @default.
• W4316363079 cites W2797407068 @default.
• W4316363079 cites W2889026937 @default.
• W4316363079 cites W2900661972 @default.
• W4316363079 cites W2904984201 @default.
• W4316363079 cites W2917253379 @default.
• W4316363079 cites W2917837889 @default.
• W4316363079 cites W2943769232 @default.
• W4316363079 cites W2969737037 @default.
• W4316363079 cites W2988278332 @default.
• W4316363079 cites W2999318269 @default.
• W4316363079 cites W3017051093 @default.
• W4316363079 cites W3037800773 @default.
• W4316363079 cites W4231021828 @default.
• W4316363079 doi "https://doi.org/10.1186/s12957-023-02887-0" @default.
• W4316363079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36647123" @default.
• W4316363079 hasPublicationYear "2023" @default.
• W4316363079 type Work @default.
• W4316363079 citedByCount "0" @default.
• W4316363079 crossrefType "journal-article" @default.
• W4316363079 hasAuthorship W4316363079A5000385500 @default.
• W4316363079 hasAuthorship W4316363079A5022874036 @default.
• W4316363079 hasAuthorship W4316363079A5039432451 @default.
• W4316363079 hasAuthorship W4316363079A5067160675 @default.
• W4316363079 hasAuthorship W4316363079A5073831136 @default.
• W4316363079 hasBestOaLocation W43163630791 @default.
• W4316363079 hasConcept C121608353 @default.
• W4316363079 hasConcept C126322002 @default.
• W4316363079 hasConcept C141071460 @default.
• W4316363079 hasConcept C143998085 @default.
• W4316363079 hasConcept C146357865 @default.
• W4316363079 hasConcept C151730666 @default.
• W4316363079 hasConcept C167135981 @default.
• W4316363079 hasConcept C207103383 @default.
• W4316363079 hasConcept C2777761686 @default.
• W4316363079 hasConcept C2778963024 @default.
• W4316363079 hasConcept C2779134260 @default.
• W4316363079 hasConcept C2780140570 @default.
• W4316363079 hasConcept C2780470880 @default.
• W4316363079 hasConcept C31174226 @default.
• W4316363079 hasConcept C44249647 @default.
• W4316363079 hasConcept C50382708 @default.
• W4316363079 hasConcept C71924100 @default.
• W4316363079 hasConcept C86803240 @default.
• W4316363079 hasConcept C90924648 @default.
• W4316363079 hasConceptScore W4316363079C121608353 @default.
• W4316363079 hasConceptScore W4316363079C126322002 @default.
• W4316363079 hasConceptScore W4316363079C141071460 @default.
• W4316363079 hasConceptScore W4316363079C143998085 @default.
• W4316363079 hasConceptScore W4316363079C146357865 @default.
• W4316363079 hasConceptScore W4316363079C151730666 @default.
• W4316363079 hasConceptScore W4316363079C167135981 @default.
• W4316363079 hasConceptScore W4316363079C207103383 @default.
• W4316363079 hasConceptScore W4316363079C2777761686 @default.
• W4316363079 hasConceptScore W4316363079C2778963024 @default.
• W4316363079 hasConceptScore W4316363079C2779134260 @default.
• W4316363079 hasConceptScore W4316363079C2780140570 @default.
• W4316363079 hasConceptScore W4316363079C2780470880 @default.
• W4316363079 hasConceptScore W4316363079C31174226 @default.
• W4316363079 hasConceptScore W4316363079C44249647 @default.
• W4316363079 hasConceptScore W4316363079C50382708 @default.
• W4316363079 hasConceptScore W4316363079C71924100 @default.
• W4316363079 hasConceptScore W4316363079C86803240 @default.
• W4316363079 hasConceptScore W4316363079C90924648 @default.
• W4316363079 hasIssue "1" @default.
• W4316363079 hasLocation W43163630791 @default.

• next