Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316363080> ?p ?o ?g. }
- W4316363080 endingPage "1957" @default.
- W4316363080 startingPage "1943" @default.
- W4316363080 abstract "Radioresistance remains a major obstacle to efficacious radiotherapy in non-small-cell lung cancer (NSCLC). DNA replication proteins are novel targets for radiosensitizers. POLQ is a DNA polymerase involved in DNA damage response and repair. We found that POLQ is overexpressed in NSCLC and is clinically correlated with high tumor stage, poor prognosis, increased tumor mutational burden, and ALK and TP5 mutation status; POLQ inhibition impaired lung tumorigenesis. Notably, POLQ expression was higher in radioresistant lung cancer cells than in wild-type cancer cells. Moreover, POLQ expression was further increased in radioresistant cells after radiation. Enhanced radioresistance is through a prolonged G2/M phase and faster repair of DNA damage, leading to reduced radiation-induced apoptosis. Novobiocin (NVB), a POLQ inhibitor, specifically targeted cancer cells. Genetic knockdown of POLQ or pharmacological inhibition by NVB decreased radioresistance in lung adenocarcinoma while causing little toxicity to normal pulmonary epithelial cells. In conclusion, POLQ is a promising and practical cancer-specific target to impair tumorigenesis and enhance radiosensitivity in NSCLC." @default.
- W4316363080 created "2023-01-16" @default.
- W4316363080 creator A5006561796 @default.
- W4316363080 creator A5021119255 @default.
- W4316363080 creator A5021882528 @default.
- W4316363080 creator A5026233155 @default.
- W4316363080 creator A5037467317 @default.
- W4316363080 creator A5038365435 @default.
- W4316363080 creator A5045692618 @default.
- W4316363080 creator A5047696302 @default.
- W4316363080 creator A5047855118 @default.
- W4316363080 creator A5051760597 @default.
- W4316363080 creator A5055330527 @default.
- W4316363080 creator A5065592637 @default.
- W4316363080 creator A5065661976 @default.
- W4316363080 creator A5077703494 @default.
- W4316363080 creator A5080381497 @default.
- W4316363080 creator A5082437078 @default.
- W4316363080 creator A5091000947 @default.
- W4316363080 date "2023-02-02" @default.
- W4316363080 modified "2023-10-03" @default.
- W4316363080 title "Targeting polymerase θ impairs tumorigenesis and enhances radiosensitivity in lung adenocarcinoma" @default.
- W4316363080 cites W1982957001 @default.
- W4316363080 cites W1999574084 @default.
- W4316363080 cites W2004567122 @default.
- W4316363080 cites W2010457001 @default.
- W4316363080 cites W2020426424 @default.
- W4316363080 cites W2049553585 @default.
- W4316363080 cites W2065078241 @default.
- W4316363080 cites W2107632586 @default.
- W4316363080 cites W2130193848 @default.
- W4316363080 cites W2130410032 @default.
- W4316363080 cites W2133465414 @default.
- W4316363080 cites W2154472830 @default.
- W4316363080 cites W2168396953 @default.
- W4316363080 cites W2179438025 @default.
- W4316363080 cites W2391227084 @default.
- W4316363080 cites W2560367415 @default.
- W4316363080 cites W2768434280 @default.
- W4316363080 cites W2792367044 @default.
- W4316363080 cites W2794844459 @default.
- W4316363080 cites W2908842729 @default.
- W4316363080 cites W2946050032 @default.
- W4316363080 cites W2956638290 @default.
- W4316363080 cites W3033843978 @default.
- W4316363080 cites W3045935025 @default.
- W4316363080 cites W3094286291 @default.
- W4316363080 cites W3097803258 @default.
- W4316363080 cites W3109281567 @default.
- W4316363080 cites W3119311457 @default.
- W4316363080 cites W3126213490 @default.
- W4316363080 cites W3128544040 @default.
- W4316363080 cites W3137550592 @default.
- W4316363080 cites W3172714441 @default.
- W4316363080 cites W3194003153 @default.
- W4316363080 cites W4211059596 @default.
- W4316363080 cites W4283369122 @default.
- W4316363080 cites W4284883225 @default.
- W4316363080 cites W4307045770 @default.
- W4316363080 cites W4316363080 @default.
- W4316363080 doi "https://doi.org/10.1111/cas.15727" @default.
- W4316363080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36642785" @default.
- W4316363080 hasPublicationYear "2023" @default.
- W4316363080 type Work @default.
- W4316363080 citedByCount "3" @default.
- W4316363080 countsByYear W43163630802023 @default.
- W4316363080 crossrefType "journal-article" @default.
- W4316363080 hasAuthorship W4316363080A5006561796 @default.
- W4316363080 hasAuthorship W4316363080A5021119255 @default.
- W4316363080 hasAuthorship W4316363080A5021882528 @default.
- W4316363080 hasAuthorship W4316363080A5026233155 @default.
- W4316363080 hasAuthorship W4316363080A5037467317 @default.
- W4316363080 hasAuthorship W4316363080A5038365435 @default.
- W4316363080 hasAuthorship W4316363080A5045692618 @default.
- W4316363080 hasAuthorship W4316363080A5047696302 @default.
- W4316363080 hasAuthorship W4316363080A5047855118 @default.
- W4316363080 hasAuthorship W4316363080A5051760597 @default.
- W4316363080 hasAuthorship W4316363080A5055330527 @default.
- W4316363080 hasAuthorship W4316363080A5065592637 @default.
- W4316363080 hasAuthorship W4316363080A5065661976 @default.
- W4316363080 hasAuthorship W4316363080A5077703494 @default.
- W4316363080 hasAuthorship W4316363080A5080381497 @default.
- W4316363080 hasAuthorship W4316363080A5082437078 @default.
- W4316363080 hasAuthorship W4316363080A5091000947 @default.
- W4316363080 hasBestOaLocation W43163630801 @default.
- W4316363080 hasConcept C121608353 @default.
- W4316363080 hasConcept C126322002 @default.
- W4316363080 hasConcept C134935766 @default.
- W4316363080 hasConcept C142724271 @default.
- W4316363080 hasConcept C143425029 @default.
- W4316363080 hasConcept C206684579 @default.
- W4316363080 hasConcept C2776256026 @default.
- W4316363080 hasConcept C502942594 @default.
- W4316363080 hasConcept C509974204 @default.
- W4316363080 hasConcept C54355233 @default.
- W4316363080 hasConcept C552990157 @default.
- W4316363080 hasConcept C555283112 @default.
- W4316363080 hasConcept C58962609 @default.