FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316363566> ?p ?o ?g. }

• W4316363566 abstract "Detection of patient- and tumor-specific clonally rearranged immune receptor genes using real-time quantitative (RQ)-PCR is an accepted method in the field of precision medicine for hematologic malignancies. As individual primers are needed for each patient and leukemic clone, establishing performance specifications for the method faces unique challenges. Results for series of diagnostic assays for CLL and ALL patients demonstrate that the analytic performance of the method is not dependent on patients’ disease characteristics. The calibration range is linear between 10 -1 and 10 -5 for 90% of all assays. The detection limit of the current standardized approach is between 1.8 and 4.8 cells among 100,000 leukocytes. RQ-PCR has about 90% overall agreement to flow cytometry and next generation sequencing as orthogonal methods. Accuracy and precision across different labs, and above and below the clinically applied cutoffs for minimal/measurable residual disease (MRD) demonstrate the robustness of the technique. The here reported comprehensive, IVD-guided analytical validation provides evidence that the personalized diagnostic methodology generates robust, reproducible and specific MRD data when standardized protocols for data generation and evaluation are used. Our approach may also serve as a guiding example of how to accomplish analytical validation of personalized in-house diagnostics under the European IVD Regulation." @default.
• W4316363566 created "2023-01-16" @default.
• W4316363566 creator A5009933907 @default.
• W4316363566 creator A5015242520 @default.
• W4316363566 creator A5020857454 @default.
• W4316363566 creator A5027341200 @default.
• W4316363566 creator A5050811096 @default.
• W4316363566 creator A5052961120 @default.
• W4316363566 creator A5056292685 @default.
• W4316363566 creator A5061054700 @default.
• W4316363566 creator A5061380659 @default.
• W4316363566 creator A5063137777 @default.
• W4316363566 creator A5068043845 @default.
• W4316363566 creator A5071552171 @default.
• W4316363566 creator A5075073484 @default.
• W4316363566 creator A5076709979 @default.
• W4316363566 creator A5082735172 @default.
• W4316363566 date "2023-01-16" @default.
• W4316363566 modified "2023-10-15" @default.
• W4316363566 title "Patient specific real-time PCR in precision medicine – Validation of IG/TR based MRD assessment in lymphoid leukemia" @default.
• W4316363566 cites W1239385015 @default.
• W4316363566 cites W1485389706 @default.
• W4316363566 cites W1580687288 @default.
• W4316363566 cites W1607671459 @default.
• W4316363566 cites W1977632364 @default.
• W4316363566 cites W1998660089 @default.
• W4316363566 cites W2004923784 @default.
• W4316363566 cites W2039642633 @default.
• W4316363566 cites W2069085828 @default.
• W4316363566 cites W2070350286 @default.
• W4316363566 cites W2070993076 @default.
• W4316363566 cites W2071899049 @default.
• W4316363566 cites W2075197983 @default.
• W4316363566 cites W2096278562 @default.
• W4316363566 cites W2098746581 @default.
• W4316363566 cites W2100025372 @default.
• W4316363566 cites W2116324811 @default.
• W4316363566 cites W2131986125 @default.
• W4316363566 cites W2132827894 @default.
• W4316363566 cites W2151069914 @default.
• W4316363566 cites W2152615936 @default.
• W4316363566 cites W2156265008 @default.
• W4316363566 cites W2156423011 @default.
• W4316363566 cites W2158240777 @default.
• W4316363566 cites W2159325547 @default.
• W4316363566 cites W2168604963 @default.
• W4316363566 cites W2169269721 @default.
• W4316363566 cites W2221325899 @default.
• W4316363566 cites W2329186770 @default.
• W4316363566 cites W2337195173 @default.
• W4316363566 cites W2901005342 @default.
• W4316363566 cites W2902102813 @default.
• W4316363566 cites W2905098828 @default.
• W4316363566 cites W2953485549 @default.
• W4316363566 cites W2974918641 @default.
• W4316363566 cites W2991068499 @default.
• W4316363566 cites W3096986475 @default.
• W4316363566 cites W3104573671 @default.
• W4316363566 cites W3204288598 @default.
• W4316363566 cites W3209416216 @default.
• W4316363566 cites W3211680960 @default.
• W4316363566 cites W4206124498 @default.
• W4316363566 cites W4295038000 @default.
• W4316363566 doi "https://doi.org/10.3389/fonc.2022.1111209" @default.
• W4316363566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36727082" @default.
• W4316363566 hasPublicationYear "2023" @default.
• W4316363566 type Work @default.
• W4316363566 citedByCount "0" @default.
• W4316363566 crossrefType "journal-article" @default.
• W4316363566 hasAuthorship W4316363566A5009933907 @default.
• W4316363566 hasAuthorship W4316363566A5015242520 @default.
• W4316363566 hasAuthorship W4316363566A5020857454 @default.
• W4316363566 hasAuthorship W4316363566A5027341200 @default.
• W4316363566 hasAuthorship W4316363566A5050811096 @default.
• W4316363566 hasAuthorship W4316363566A5052961120 @default.
• W4316363566 hasAuthorship W4316363566A5056292685 @default.
• W4316363566 hasAuthorship W4316363566A5061054700 @default.
• W4316363566 hasAuthorship W4316363566A5061380659 @default.
• W4316363566 hasAuthorship W4316363566A5063137777 @default.
• W4316363566 hasAuthorship W4316363566A5068043845 @default.
• W4316363566 hasAuthorship W4316363566A5071552171 @default.
• W4316363566 hasAuthorship W4316363566A5075073484 @default.
• W4316363566 hasAuthorship W4316363566A5076709979 @default.
• W4316363566 hasAuthorship W4316363566A5082735172 @default.
• W4316363566 hasBestOaLocation W43163635661 @default.
• W4316363566 hasConcept C104317684 @default.
• W4316363566 hasConcept C142724271 @default.
• W4316363566 hasConcept C143998085 @default.
• W4316363566 hasConcept C163763905 @default.
• W4316363566 hasConcept C203014093 @default.
• W4316363566 hasConcept C2778461978 @default.
• W4316363566 hasConcept C2779823535 @default.
• W4316363566 hasConcept C32220436 @default.
• W4316363566 hasConcept C54355233 @default.
• W4316363566 hasConcept C60644358 @default.
• W4316363566 hasConcept C63479239 @default.
• W4316363566 hasConcept C70721500 @default.
• W4316363566 hasConcept C71924100 @default.
• W4316363566 hasConcept C86803240 @default.
• W4316363566 hasConceptScore W4316363566C104317684 @default.

• next