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• W4316464547 abstract "Abstract Introduction The presentation of the course of COVID-19-related T-cell responses in the first week of the disease may be a more specific period for adaptive immune response assessment. This study aimed to clarify the relationship between changes in peripheral blood lymphocyte counts and death in patients with COVID-19 pneumonia. Methods Thirty-three patients (14 females and 19 males) admitted for severe and desaturated COVID-19 pneumonia confirmed by polymerase chain reaction were included. Lymphocyte subsets and CD4 + /CD8 + and CD16 + /CD56 + rates were measured using flow cytometry from peripheral blood at admission and on the day of death or hospital discharge. Results Twenty-eight patients survived and five died. On the day of admission, the CD4 + cell count was significantly higher and the saturation of O 2 was significantly lower in the deceased patients compared to the survivors ( P < 0.05). The CD16 + /CD56 + rate was significantly lower on the day of death in the deceased patients than in discharge day for the survivors ( P = 0.013). Conclusion CD4 + lymphocyte percentages and O2 saturation in samples taken on the day of admission to the hospital and CD16+/CD56+ ratios taken at the time of discharge from the hospital were found to be associated with the mortality in patients with severe COVID-19." @default.
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• W4316464547 date "2023-01-20" @default.
• W4316464547 modified "2023-09-26" @default.
• W4316464547 title "Adaptive immune system in severe COVID-19 patients in the first week of illness: A pilot study" @default.
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• W4316464547 doi "https://doi.org/10.1556/1886.2022.00022" @default.
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