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• W4316465956 endingPage "117955492211479" @default.
• W4316465956 startingPage "117955492211479" @default.
• W4316465956 abstract "Assessing the prognosis preoperatively in patients with upper tract urothelial carcinoma (UTUC) remains a challenge for urologists. Gross hematuria (GH) and flank pain (FP) are the 2 most common and easily perceived symptoms of UTUC. Therefore, we aimed to investigate the prognostic values of GH and FP in patients with UTUC after undergoing radical nephroureterectomy (RNU).This article retrospectively analyzed 179 patients with UTUC who underwent RNU and examined the associations between the FP, GH, and long-term survival. After dividing patients into 4 subgroups (presenting as GH without FP, FP without GH, no FP and GH, FP with GH), we focused on the prognostic values of the 4 subgroups using univariate and multivariate analyses. We then proposed a risk stratification model for UTUC based on the independent prognostic factors for cancer-specific survival (CSS) with external validation (146 additional UTUC patients formed the validation cohort).Patients with FP had worse oncological outcomes than those without FP (P < .05). After dividing the 179 patients into 4 subgroups, the FP without GH subgroup suffered the worst oncological outcomes (P < .001). The Cox multivariate regression analysis showed that FP without GH (P < .001), tumor multifocality (P = .005), and pathological stage (P = .004) were independent prognostic factors for CSS. Good performance of the risk stratification model was achieved in both the training and external validation cohorts.The presence of flank pain without gross hematuria was one of the independent risk factors of CSS and OS besides the pathological stage and tumor multifocality. To our knowledge, this is the first study that adding complaint to risk stratification model in UTUC." @default.
• W4316465956 created "2023-01-16" @default.
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• W4316465956 date "2023-01-01" @default.
• W4316465956 modified "2023-09-26" @default.
• W4316465956 title "Predictive Value of Flank Pain and Gross Hematuria on Long-Term Survival in Patients With Upper Tract Urothelial Carcinoma Treated by Radical Nephroureterectomy" @default.
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• W4316465956 doi "https://doi.org/10.1177/11795549221147993" @default.
• W4316465956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685988" @default.
• W4316465956 hasPublicationYear "2023" @default.
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