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- W4316466582 endingPage "156" @default.
- W4316466582 startingPage "156" @default.
- W4316466582 abstract "Background: Existing studies indicate that some computed tomography perfusion (CTP) parameters may predict hemorrhagic transformation (HT) after acute ischemic stroke (AIS), but there is an inconsistency in the conclusions alongside a lack of comprehensive comparison. Objective: To comprehensively evaluate the predictive value of CTP parameters in HT after AIS. Data sources: A systematical literature review of existing studies was conducted up to 1st October 2022 in six mainstream databases that included original data on the CTP parameters of HT and non-HT groups or on the diagnostic performance of relative cerebral blood flow (rCBF), relative permeability-surface area product (rPS), or relative cerebral blood volume (rCBV) in patients with AIS that completed CTP within 24 h of onset. Data Synthesis: Eighteen observational studies were included. HT and non-HT groups had statistically significant differences in CBF, CBV, PS, rCBF, rCBV, and rPS (p < 0.05 for all). The hierarchical summary receiver operating characteristic (HSROC) revealed that rCBF (area under the curve (AUC) = 0.9), rPS (AUC = 0.89), and rCBV (AUC = 0.85) had moderate diagnostic performances in predicting HT. The pooled sensitivity and specificity of rCBF were 0.85 (95% CI, 0.75−0.91) and 0.83 (95% CI, 0.63−0.94), respectively. Conclusions: rCBF, rPS, and rCBV had moderate diagnostic performances in predicting HT, and rCBF had the best pooled sensitivity and specificity." @default.
- W4316466582 created "2023-01-16" @default.
- W4316466582 creator A5001000866 @default.
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- W4316466582 date "2023-01-16" @default.
- W4316466582 modified "2023-09-30" @default.
- W4316466582 title "Predictive Value of CT Perfusion in Hemorrhagic Transformation after Acute Ischemic Stroke: A Systematic Review and Meta-Analysis" @default.
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- W4316466582 doi "https://doi.org/10.3390/brainsci13010156" @default.
- W4316466582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672136" @default.
- W4316466582 hasPublicationYear "2023" @default.
- W4316466582 type Work @default.