Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316467054> ?p ?o ?g. }
- W4316467054 endingPage "275" @default.
- W4316467054 startingPage "264" @default.
- W4316467054 abstract "Abstract Melanoma is a highly aggressive tumor derived from melanocytes. In recent years, the incidence and mortality of melanoma have gradually increased, seriously threatening human health. Classic treatments like surgery, chemotherapy, and radiotherapy show very limited efficacy. Due to the high immunogenicity of melanoma cells, immune checkpoint inhibitors have received considerable attention as melanoma treatments. One such therapy is blockade of programmed cell death‐1 (PD‐1), which is one of the most important negative immune regulators and is mainly expressed on activated T cells. Disruption of the interactions between PD‐1 and its ligands, programmed death‐ligand 1 (PD‐L1) or programmed death‐ligand 2 (PD‐L2) rejuvenates exhausted T cells and enhances antitumor immunity. Although PD‐1 blockade therapy is widely used in melanoma, a substantial proportion of patients still show no response or short durations of remission. Recent researches have focused on revealing the underlying mechanisms for resistance to this treatment and improving its efficacy through combination therapy. Here, we will introduce the resistance mechanisms associated with PD‐1 blockade therapy in melanoma and review the combination therapies available." @default.
- W4316467054 created "2023-01-16" @default.
- W4316467054 creator A5018745115 @default.
- W4316467054 creator A5049036663 @default.
- W4316467054 date "2023-01-24" @default.
- W4316467054 modified "2023-10-14" @default.
- W4316467054 title "Programmed cell death‐1 blockade therapy in melanoma: Resistance mechanisms and combination strategies" @default.
- W4316467054 cites W1498931318 @default.
- W4316467054 cites W1905337938 @default.
- W4316467054 cites W2099432296 @default.
- W4316467054 cites W2102532180 @default.
- W4316467054 cites W2122037714 @default.
- W4316467054 cites W2134605629 @default.
- W4316467054 cites W2142160537 @default.
- W4316467054 cites W2146774792 @default.
- W4316467054 cites W2153162429 @default.
- W4316467054 cites W2169964565 @default.
- W4316467054 cites W2185075416 @default.
- W4316467054 cites W2201379305 @default.
- W4316467054 cites W2299181842 @default.
- W4316467054 cites W2465860350 @default.
- W4316467054 cites W2469291698 @default.
- W4316467054 cites W2547310148 @default.
- W4316467054 cites W2560185130 @default.
- W4316467054 cites W2577256604 @default.
- W4316467054 cites W2591993163 @default.
- W4316467054 cites W2606711458 @default.
- W4316467054 cites W2742188140 @default.
- W4316467054 cites W2755181857 @default.
- W4316467054 cites W2779221466 @default.
- W4316467054 cites W2779658193 @default.
- W4316467054 cites W2783011222 @default.
- W4316467054 cites W2883970691 @default.
- W4316467054 cites W2888914203 @default.
- W4316467054 cites W2890274375 @default.
- W4316467054 cites W2897022305 @default.
- W4316467054 cites W2905049840 @default.
- W4316467054 cites W2914903153 @default.
- W4316467054 cites W2922700235 @default.
- W4316467054 cites W2932539907 @default.
- W4316467054 cites W2943793201 @default.
- W4316467054 cites W2947286502 @default.
- W4316467054 cites W2953467762 @default.
- W4316467054 cites W2964582701 @default.
- W4316467054 cites W2965059444 @default.
- W4316467054 cites W2965085097 @default.
- W4316467054 cites W2967820098 @default.
- W4316467054 cites W2970210098 @default.
- W4316467054 cites W2980394375 @default.
- W4316467054 cites W2983683104 @default.
- W4316467054 cites W2983934251 @default.
- W4316467054 cites W2990621788 @default.
- W4316467054 cites W2993784633 @default.
- W4316467054 cites W3001874526 @default.
- W4316467054 cites W3004467236 @default.
- W4316467054 cites W3007959681 @default.
- W4316467054 cites W3017127491 @default.
- W4316467054 cites W3020133834 @default.
- W4316467054 cites W3029238268 @default.
- W4316467054 cites W3039388108 @default.
- W4316467054 cites W3041229190 @default.
- W4316467054 cites W3042410851 @default.
- W4316467054 cites W3086146444 @default.
- W4316467054 cites W3090593425 @default.
- W4316467054 cites W3092653799 @default.
- W4316467054 cites W3093383535 @default.
- W4316467054 cites W3097696756 @default.
- W4316467054 cites W3097722171 @default.
- W4316467054 cites W3099271991 @default.
- W4316467054 cites W3111836013 @default.
- W4316467054 cites W3125107188 @default.
- W4316467054 cites W3126208996 @default.
- W4316467054 cites W3127508971 @default.
- W4316467054 cites W3130683366 @default.
- W4316467054 cites W3130698437 @default.
- W4316467054 cites W3133720646 @default.
- W4316467054 cites W3135494620 @default.
- W4316467054 cites W3136384690 @default.
- W4316467054 cites W3157507277 @default.
- W4316467054 cites W3163174031 @default.
- W4316467054 cites W3172691600 @default.
- W4316467054 cites W3177071586 @default.
- W4316467054 cites W3186003333 @default.
- W4316467054 cites W3193329422 @default.
- W4316467054 cites W3195642548 @default.
- W4316467054 cites W3196177384 @default.
- W4316467054 cites W3209494262 @default.
- W4316467054 cites W4200168827 @default.
- W4316467054 cites W4200495164 @default.
- W4316467054 cites W4210321755 @default.
- W4316467054 cites W4210433978 @default.
- W4316467054 cites W4211133027 @default.
- W4316467054 cites W4212858198 @default.
- W4316467054 cites W4214816481 @default.
- W4316467054 cites W4220682839 @default.
- W4316467054 cites W4225394054 @default.
- W4316467054 cites W4225529913 @default.
- W4316467054 cites W4226229241 @default.