FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316468087> ?p ?o ?g. }

• W4316468087 abstract "Abstract Background and aims Data on the outcome and prognostic indicators in extracranial relapsed/refractory germ cell tumors (rel/ref‐GCTs) in children are limited to a few studies. This study looks at remission rates and outcomes of rel/ref‐GCTs treated with conventional salvage chemotherapy (SC) regimens without stem cell rescue at a single center in the developing world. Methods Patients treated at our center from January 2009 to December 2018 were included. Risk at primary presentation was stratified as all completely excised teratomas and stage I gonadal tumors being low risk (LR); stage IV ovarian, stage III–IV extragonadal GCTs as high risk (HR), and the remaining as intermediate risk (IR). SC regimens were: vinblastine–ifosfamide–cisplatin/carboplatin or paclitaxel–ifosfamide–cisplatin/carboplatin, or cisplatin/carboplatin–etoposide–bleomycin. Local therapy was either surgery and/or radiotherapy. Results The analyzable cohort comprised 50 patients (44 = rel‐GCTs; 6 = ref‐GCTs) with a median age of 3.8 years and male:female ratio of 1.27:1. Primary location was ovary in 16 (32%), testicular in 10 (20%), and extragonadal in the rest (48%). Local, metastatic, and combined progression was noted in 28 (56%), 14 (28%), and eight (16%) patients, respectively, at a median time of 8.5 months. At a median follow‐up of 60 months, the 5‐year event‐free survival (EFS) and overall survival (OS) of the entire cohort ( n = 50) were 42.4% and 50.0%, respectively. In patients previously exposed to platinum analogs ( n = 38), 5‐year‐EFS and OS were 27.7% and 31.7%, respectively. Local relapses did better when compared to metastatic and combined relapses (5‐year EFS: 64% vs. 23% vs. 0%; p = .009). LR and IR tumors did better compared to HR (5‐year EFS: 81.5% vs. 49.3% vs. 6.5%; p = .002). Patients with normalization of tumor markers after two cycles had a superior EFS (57.6% vs. 0%; p < .001). Relapsed tumors fared better than primary refractory GCTs (5‐year EFS: 48.6% vs. 0%; p < .001). Conclusions Primary refractory GCTs, extragonadal rel‐GCTs, and rel/ref‐GCTs with a poor biochemical response did poorly with conventional SC and need alternative treatment strategies. The rel/ref‐testicular GCTs had the best chance of salvage despite a second recurrence (5‐year EFS and OS: 28.60% and 42.90%, respectively)." @default.
• W4316468087 created "2023-01-16" @default.
• W4316468087 creator A5010905564 @default.
• W4316468087 creator A5019873470 @default.
• W4316468087 creator A5040698379 @default.
• W4316468087 creator A5058637504 @default.
• W4316468087 creator A5058678502 @default.
• W4316468087 creator A5069101546 @default.
• W4316468087 creator A5071018405 @default.
• W4316468087 creator A5072213140 @default.
• W4316468087 creator A5072969277 @default.
• W4316468087 creator A5076083066 @default.
• W4316468087 creator A5082487593 @default.
• W4316468087 creator A5087984426 @default.
• W4316468087 date "2023-01-16" @default.
• W4316468087 modified "2023-10-14" @default.
• W4316468087 title "Outcomes of relapsed/refractory extracranial germ cell tumors treated on conventional salvage chemotherapy without stem cell rescue: Experience from a tertiary cancer center" @default.
• W4316468087 cites W1748674096 @default.
• W4316468087 cites W1766190935 @default.
• W4316468087 cites W1848125246 @default.
• W4316468087 cites W1993197773 @default.
• W4316468087 cites W2042770658 @default.
• W4316468087 cites W205553958 @default.
• W4316468087 cites W2090777634 @default.
• W4316468087 cites W2095955563 @default.
• W4316468087 cites W2126978371 @default.
• W4316468087 cites W2145842223 @default.
• W4316468087 cites W2161239389 @default.
• W4316468087 cites W2163130660 @default.
• W4316468087 cites W2168588194 @default.
• W4316468087 cites W2314798016 @default.
• W4316468087 cites W2555626407 @default.
• W4316468087 cites W2801520207 @default.
• W4316468087 cites W2995997172 @default.
• W4316468087 cites W4280575917 @default.
• W4316468087 doi "https://doi.org/10.1002/pbc.30179" @default.
• W4316468087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36645132" @default.
• W4316468087 hasPublicationYear "2023" @default.
• W4316468087 type Work @default.
• W4316468087 citedByCount "0" @default.
• W4316468087 crossrefType "journal-article" @default.
• W4316468087 hasAuthorship W4316468087A5010905564 @default.
• W4316468087 hasAuthorship W4316468087A5019873470 @default.
• W4316468087 hasAuthorship W4316468087A5040698379 @default.
• W4316468087 hasAuthorship W4316468087A5058637504 @default.
• W4316468087 hasAuthorship W4316468087A5058678502 @default.
• W4316468087 hasAuthorship W4316468087A5069101546 @default.
• W4316468087 hasAuthorship W4316468087A5071018405 @default.
• W4316468087 hasAuthorship W4316468087A5072213140 @default.
• W4316468087 hasAuthorship W4316468087A5072969277 @default.
• W4316468087 hasAuthorship W4316468087A5076083066 @default.
• W4316468087 hasAuthorship W4316468087A5082487593 @default.
• W4316468087 hasAuthorship W4316468087A5087984426 @default.
• W4316468087 hasConcept C126322002 @default.
• W4316468087 hasConcept C141071460 @default.
• W4316468087 hasConcept C143998085 @default.
• W4316468087 hasConcept C2776694085 @default.
• W4316468087 hasConcept C2776938808 @default.
• W4316468087 hasConcept C2777506904 @default.
• W4316468087 hasConcept C2778119113 @default.
• W4316468087 hasConcept C2778239845 @default.
• W4316468087 hasConcept C2780775027 @default.
• W4316468087 hasConcept C2781451048 @default.
• W4316468087 hasConcept C71924100 @default.
• W4316468087 hasConceptScore W4316468087C126322002 @default.
• W4316468087 hasConceptScore W4316468087C141071460 @default.
• W4316468087 hasConceptScore W4316468087C143998085 @default.
• W4316468087 hasConceptScore W4316468087C2776694085 @default.
• W4316468087 hasConceptScore W4316468087C2776938808 @default.
• W4316468087 hasConceptScore W4316468087C2777506904 @default.
• W4316468087 hasConceptScore W4316468087C2778119113 @default.
• W4316468087 hasConceptScore W4316468087C2778239845 @default.
• W4316468087 hasConceptScore W4316468087C2780775027 @default.
• W4316468087 hasConceptScore W4316468087C2781451048 @default.
• W4316468087 hasConceptScore W4316468087C71924100 @default.
• W4316468087 hasIssue "4" @default.
• W4316468087 hasLocation W43164680871 @default.
• W4316468087 hasLocation W43164680872 @default.
• W4316468087 hasOpenAccess W4316468087 @default.
• W4316468087 hasPrimaryLocation W43164680871 @default.
• W4316468087 hasRelatedWork W1995297926 @default.
• W4316468087 hasRelatedWork W203516936 @default.
• W4316468087 hasRelatedWork W2416637456 @default.
• W4316468087 hasRelatedWork W2466567915 @default.
• W4316468087 hasRelatedWork W2600735778 @default.
• W4316468087 hasRelatedWork W2789166760 @default.
• W4316468087 hasRelatedWork W2805901899 @default.
• W4316468087 hasRelatedWork W4310946033 @default.
• W4316468087 hasRelatedWork W6933653 @default.
• W4316468087 hasRelatedWork W2133000900 @default.
• W4316468087 hasVolume "70" @default.
• W4316468087 isParatext "false" @default.
• W4316468087 isRetracted "false" @default.
• W4316468087 workType "article" @default.