Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316496654> ?p ?o ?g. }
- W4316496654 endingPage "92" @default.
- W4316496654 startingPage "81" @default.
- W4316496654 abstract "Biological milieus are highly crowded and heterogeneous systems where organization of macromolecules within nanodomains (e.g. membraneless compartments) is vital to the regulation of metabolic processes. There is an increasing interest in understanding the effects that such packed environments have on different biochemical and biological processes. In this context, the redox biochemistry and redox signaling fields are moving towards investigating oxidative processes under conditions that exhibit these key features of biological systems in order to solve existing paradigms including those related to the generation and transmission of specific redox signals within and between cells in both normal physiology and under conditions of oxidative stress. This review outlines the effects that crowding, nanodomain formation and altered local viscosities can have on biochemical processes involving proteins, and then discusses some of the reactions and pathways involving proteins and oxidants that may, or are known to, be modulated by these factors. We postulate that knowledge of protein modification processes (e.g. kinetics, pathways and product formation) under conditions that mimic biological milieus, will provide a better understanding of the response of cells to endogenous and exogenous stressors, and their role in ageing, signaling, health and disease." @default.
- W4316496654 created "2023-01-16" @default.
- W4316496654 creator A5081391738 @default.
- W4316496654 creator A5084024321 @default.
- W4316496654 date "2023-02-01" @default.
- W4316496654 modified "2023-10-18" @default.
- W4316496654 title "Effect of crowding, compartmentalization and nanodomains on protein modification and redox signaling – current state and future challenges" @default.
- W4316496654 cites W1566636169 @default.
- W4316496654 cites W1659688442 @default.
- W4316496654 cites W1757241200 @default.
- W4316496654 cites W1885590713 @default.
- W4316496654 cites W1957064683 @default.
- W4316496654 cites W1973897761 @default.
- W4316496654 cites W1975084717 @default.
- W4316496654 cites W1976314139 @default.
- W4316496654 cites W1978705679 @default.
- W4316496654 cites W1978739111 @default.
- W4316496654 cites W1980983550 @default.
- W4316496654 cites W1983903436 @default.
- W4316496654 cites W1985229185 @default.
- W4316496654 cites W1985963784 @default.
- W4316496654 cites W1986606329 @default.
- W4316496654 cites W1987741979 @default.
- W4316496654 cites W1991952977 @default.
- W4316496654 cites W1994500027 @default.
- W4316496654 cites W1996379107 @default.
- W4316496654 cites W2005082047 @default.
- W4316496654 cites W2006008435 @default.
- W4316496654 cites W2006260865 @default.
- W4316496654 cites W2006512709 @default.
- W4316496654 cites W2011593105 @default.
- W4316496654 cites W2012742333 @default.
- W4316496654 cites W2017118016 @default.
- W4316496654 cites W2023436768 @default.
- W4316496654 cites W2023657292 @default.
- W4316496654 cites W2034470039 @default.
- W4316496654 cites W2040447429 @default.
- W4316496654 cites W2052495152 @default.
- W4316496654 cites W2053931509 @default.
- W4316496654 cites W2054129051 @default.
- W4316496654 cites W2055185532 @default.
- W4316496654 cites W2056840435 @default.
- W4316496654 cites W2062476158 @default.
- W4316496654 cites W2066085728 @default.
- W4316496654 cites W2067939107 @default.
- W4316496654 cites W2071678672 @default.
- W4316496654 cites W2085519055 @default.
- W4316496654 cites W2087576630 @default.
- W4316496654 cites W2089618587 @default.
- W4316496654 cites W2110062635 @default.
- W4316496654 cites W2114225171 @default.
- W4316496654 cites W2136456374 @default.
- W4316496654 cites W2149790826 @default.
- W4316496654 cites W2150766477 @default.
- W4316496654 cites W2230106831 @default.
- W4316496654 cites W2259709654 @default.
- W4316496654 cites W2264152830 @default.
- W4316496654 cites W2318905955 @default.
- W4316496654 cites W2322116570 @default.
- W4316496654 cites W2340761255 @default.
- W4316496654 cites W2365565414 @default.
- W4316496654 cites W2406036039 @default.
- W4316496654 cites W2469610561 @default.
- W4316496654 cites W2523214233 @default.
- W4316496654 cites W2567907825 @default.
- W4316496654 cites W2594755419 @default.
- W4316496654 cites W2613225389 @default.
- W4316496654 cites W2624994649 @default.
- W4316496654 cites W2725756931 @default.
- W4316496654 cites W2754359238 @default.
- W4316496654 cites W2779420467 @default.
- W4316496654 cites W2799687666 @default.
- W4316496654 cites W2896751181 @default.
- W4316496654 cites W2905362390 @default.
- W4316496654 cites W2923363043 @default.
- W4316496654 cites W2936216122 @default.
- W4316496654 cites W2941923426 @default.
- W4316496654 cites W2949425085 @default.
- W4316496654 cites W2952982210 @default.
- W4316496654 cites W2963582126 @default.
- W4316496654 cites W2976800662 @default.
- W4316496654 cites W2979340817 @default.
- W4316496654 cites W2980291105 @default.
- W4316496654 cites W2989700053 @default.
- W4316496654 cites W2996774789 @default.
- W4316496654 cites W3002561686 @default.
- W4316496654 cites W3013352992 @default.
- W4316496654 cites W3031166635 @default.
- W4316496654 cites W3033309222 @default.
- W4316496654 cites W3033847448 @default.
- W4316496654 cites W3084216663 @default.
- W4316496654 cites W3092761307 @default.
- W4316496654 cites W3129589987 @default.
- W4316496654 cites W3153200590 @default.
- W4316496654 cites W3173979233 @default.
- W4316496654 cites W3184428711 @default.
- W4316496654 cites W3187018774 @default.
- W4316496654 cites W3209734890 @default.