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- W4316500281 abstract "This chapter focuses on the proteolipid protein (PLP) gene and its expression in the developing nervous system. The myelin PLP and the related DM20 protein constitute approximately 50% of the total protein of the central nervous system (CNS) myelin membrane. In addition to the high evolutionary conservation of the protein sequence, there is also high conservation of noncoding regions of PLP mRNA. The expression of the PLP gene in Schwann cells is regulated as if it were a typical peripheral nervous system (PNS) myelin gene, but the subcellular localization of its product in the CNS and PNS is quite different. When cytoskeletal fractions were prepared from cultured cells, PLP and DM20 protein were extracted from the cytoskeletal fraction, while the myelin basic proteins remained partially associated with it. A newly described X-linked dysmyelination mutant, which appears to have a PLP-specific mutation, has a longer lifespan, with much less severe dysmyelination." @default.
- W4316500281 created "2023-01-16" @default.
- W4316500281 creator A5062518246 @default.
- W4316500281 date "2023-01-16" @default.
- W4316500281 modified "2023-10-17" @default.
- W4316500281 title "The Myelin Proteolipid Protein Gene and its Expression" @default.
- W4316500281 doi "https://doi.org/10.1201/9780203746141-12" @default.
- W4316500281 hasPublicationYear "2023" @default.
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