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- W4316505870 abstract "The coronavirus nucleocapsid (N) protein is known to bind to nucleic acids and facilitate viral genome encapsulation. Here we report that the N protein can mediate RNA or DNA entering neighboring cells through ACE2-independent, receptor (STEAP2)-mediated endocytosis, and achieve gene expression. The effect is more pronounced for the N protein of wild-type SARS-CoV-2 than that of the Omicron variant and other human coronaviruses. This effect is enhanced by RANTES (CCL5), a chemokine induced by N protein, and lactate, a metabolite produced in hypoxia, to cause more damage. These findings might explain the clinical observations in SARS-CoV-2-infected cases. Moreover, the N protein-mediated function can be inhibited by N protein-specific monoclonal antibodies or p38 mitogen-activated protein kinase inhibitors. Since the N-protein-mediated nucleic acid endocytosis involves a receptor commonly expressed in many types of cells, our findings suggest that N protein may have an additional role in SARS-CoV-2 pathogenesis." @default.
- W4316505870 created "2023-01-16" @default.
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- W4316505870 date "2023-02-01" @default.
- W4316505870 modified "2023-10-17" @default.
- W4316505870 title "SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron" @default.
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- W4316505870 cites W2089374576 @default.
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- W4316505870 doi "https://doi.org/10.1016/j.isci.2023.105995" @default.
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