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- W4316506402 endingPage "102086" @default.
- W4316506402 startingPage "102086" @default.
- W4316506402 abstract "The Wnt/β-catenin signaling pathway is highly conservative. β-catenin is the key molecule in this pathway. The β-catenin target genes regulate cell proliferation and apoptosis. Since Wnt pathway proteins are distributed on the cell membrane, cytoplasm, and nucleus, inhibiting or activating these pathway proteins presents a novel target for cancer treatment via the Wnt signaling pathway. Studies have found that this pathway plays a significant role in the formation and progression of cancers, particularly colorectal cancer. We summarised the activation and inhibition of the Wnt signaling pathway in tumors, its relationship with the microenvironment and crosstalk with other pathways, and the effect of targeting abnormal Wnt signaling in the treatment of colorectal cancer. Here is to review future targeted therapeutics in colorectal cancer research and implementation." @default.
- W4316506402 created "2023-01-16" @default.
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- W4316506402 date "2023-03-01" @default.
- W4316506402 modified "2023-10-18" @default.
- W4316506402 title "The research progress of Wnt/β-catenin signaling pathway in colorectal cancer" @default.
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- W4316506402 doi "https://doi.org/10.1016/j.clinre.2023.102086" @default.
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