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- W4316654313 abstract "Abstract Background Deep-learning-based computer-aided diagnosis (DL-CAD) systems using MRI for prostate cancer (PCa) detection have demonstrated good performance. Nevertheless, DL-CAD systems are vulnerable to high heterogeneities in DWI, which can interfere with DL-CAD assessments and impair performance. This study aims to compare PCa detection of DL-CAD between zoomed-field-of-view echo-planar DWI (z-DWI) and full-field-of-view DWI (f-DWI) and find the risk factors affecting DL-CAD diagnostic efficiency. Methods This retrospective study enrolled 354 consecutive participants who underwent MRI including T2WI, f-DWI, and z-DWI because of clinically suspected PCa. A DL-CAD was used to compare the performance of f-DWI and z-DWI both on a patient level and lesion level. We used the area under the curve (AUC) of receiver operating characteristics analysis and alternative free-response receiver operating characteristics analysis to compare the performances of DL-CAD using f- DWI and z-DWI. The risk factors affecting the DL-CAD were analyzed using logistic regression analyses. P values less than 0.05 were considered statistically significant. Results DL-CAD with z-DWI had a significantly better overall accuracy than that with f-DWI both on patient level and lesion level (AUC patient : 0.89 vs. 0.86; AUC lesion : 0.86 vs. 0.76; P < .001). The contrast-to-noise ratio (CNR) of lesions in DWI was an independent risk factor of false positives (odds ratio [OR] = 1.12; P < .001). Rectal susceptibility artifacts, lesion diameter, and apparent diffusion coefficients (ADC) were independent risk factors of both false positives (OR rectal susceptibility artifact = 5.46; OR diameter, = 1.12; OR ADC = 0.998; all P < .001) and false negatives (OR rectal susceptibility artifact = 3.31; OR diameter = 0.82; OR ADC = 1.007; all P ≤ .03) of DL-CAD. Conclusions Z-DWI has potential to improve the detection performance of a prostate MRI based DL-CAD. Trial registration ChiCTR, NO. ChiCTR2100041834 . Registered 7 January 2021." @default.
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- W4316654313 date "2023-01-17" @default.
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- W4316654313 title "Automated deep-learning system in the assessment of MRI-visible prostate cancer: comparison of advanced zoomed diffusion-weighted imaging and conventional technique" @default.
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- W4316654313 doi "https://doi.org/10.1186/s40644-023-00527-0" @default.
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