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• W4316654327 abstract "The impact of biological sex on the clinical phenotype, genotype, and outcomes among patients with MDS is not well characterized. We retrospectively reviewed the clinical and genomic data from male and female patients included in our institutional MDS database at Moffitt Cancer Center. Among 4,580 patients with MDS, 2,922 (66%) were men and 1,658 (34%) were women . Women were younger (mean age 66.5 versus 69 years for men, p < 0.001) at diagnosis. There were more Hispanic/black women than men (9% versus 5%, p =<0.001). Women had lower hemoglobin and higher platelet counts than men. More women had del 5q/monosomy 5 abnormalities compared to men (p=<0.001). Therapy related MDS were more common in women than men (25% vs.17%, p=<0.001). On assessment of molecular profile, SRSF2, U2AF1, ASXL1, and RUNX1 mutations were more frequent in men. The median overall survival (mOS) was 37.5 months (mo) for females compared to 35 mo for males, p=0.002). The mOS was significantly prolonged for women in lower-risk MDS, but not in higher-risk MDS. Women were more likely to respond to immunosuppression with ATG/CSA than men (38% versus 19%, p= 0.04). MicroAbstract: The impact of sex as a biological variable on the clinical phenotype, genotype, and outcomes among patients with myelodysplastic syndromes (MDS) is not well characterized. We retrospectively reviewed the clinical and genomic data on male and female patients included in our institutional MDS database. Disease characteristics, mutations, and survival differed between men and women." @default.
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• W4316654327 date "2023-05-01" @default.
• W4316654327 modified "2023-09-26" @default.
• W4316654327 title "Sex Disparities in Myelodysplastic Syndromes: Genotype, Phenotype, and Outcomes" @default.
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• W4316654327 doi "https://doi.org/10.1016/j.clml.2023.01.007" @default.
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