Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316661567> ?p ?o ?g. }
- W4316661567 abstract "Abstract Ample evidence reveals that glycolysis plays an important role in cancer progression; however, the underlying mechanism of its drug resistance is still worth being further explored. TRAF6, a E3 ubiquitin ligase, is well known to overexpress in various types of cancers, which predicts poor prognosis. In our study, we discovered that TRAF6 expressed more significantly in triple negative breast cancer (TNBC) than in other subtypes of breast cancers, promoting chemoresistance to paclitaxel; that the inhibited TRAF6 expression in the chemoresistant TNBC (TNBC-CR) cells enhanced the sensitivity by decreasing glucose uptake and lactate production; that TRAF6 regulated glycolysis and facilitated chemoresistance via binding directly to PKM2; and that overexpressing PKM2 in the TNBC-CR cells with TRAF6 knocked down regained significantly TRAF6-dependent drug resistance and glycolysis. Additionally, we verified that TRAF6 could facilitate PKM2-mediated glycolysis and chemoresistance in the animal models and clinical tumor tissues. Thus, we identified the novel function of TRAF6 to promote glycolysis and chemoresistance in TNBC by regulating PKM2, which could provide a potential therapeutic target for TNBC treatment." @default.
- W4316661567 created "2023-01-17" @default.
- W4316661567 creator A5005546219 @default.
- W4316661567 creator A5020517835 @default.
- W4316661567 creator A5025596555 @default.
- W4316661567 creator A5040286940 @default.
- W4316661567 creator A5040500028 @default.
- W4316661567 creator A5056183755 @default.
- W4316661567 creator A5060069116 @default.
- W4316661567 date "2023-01-16" @default.
- W4316661567 modified "2023-09-26" @default.
- W4316661567 title "TRAF6 promotes chemoresistance to paclitaxel of triple negative breast cancer via regulating PKM2-mediated glycolysis" @default.
- W4316661567 cites W1945533163 @default.
- W4316661567 cites W1995117011 @default.
- W4316661567 cites W2014409691 @default.
- W4316661567 cites W2015207840 @default.
- W4316661567 cites W2020213059 @default.
- W4316661567 cites W2029142939 @default.
- W4316661567 cites W2039676823 @default.
- W4316661567 cites W2065342065 @default.
- W4316661567 cites W2084472730 @default.
- W4316661567 cites W2095987251 @default.
- W4316661567 cites W2109491705 @default.
- W4316661567 cites W2113964895 @default.
- W4316661567 cites W2119621449 @default.
- W4316661567 cites W2122631268 @default.
- W4316661567 cites W2130503287 @default.
- W4316661567 cites W2142748510 @default.
- W4316661567 cites W2154387196 @default.
- W4316661567 cites W2162016905 @default.
- W4316661567 cites W2195075045 @default.
- W4316661567 cites W2416065856 @default.
- W4316661567 cites W2604376168 @default.
- W4316661567 cites W2625738450 @default.
- W4316661567 cites W2754782102 @default.
- W4316661567 cites W2767981580 @default.
- W4316661567 cites W2768583786 @default.
- W4316661567 cites W2803019289 @default.
- W4316661567 cites W2898397281 @default.
- W4316661567 cites W2998701262 @default.
- W4316661567 cites W3012758411 @default.
- W4316661567 cites W3200512192 @default.
- W4316661567 cites W3201475081 @default.
- W4316661567 cites W4206160812 @default.
- W4316661567 cites W4206841660 @default.
- W4316661567 cites W4220842147 @default.
- W4316661567 cites W4220865439 @default.
- W4316661567 doi "https://doi.org/10.21203/rs.3.rs-2393717/v1" @default.
- W4316661567 hasPublicationYear "2023" @default.
- W4316661567 type Work @default.
- W4316661567 citedByCount "0" @default.
- W4316661567 crossrefType "posted-content" @default.
- W4316661567 hasAuthorship W4316661567A5005546219 @default.
- W4316661567 hasAuthorship W4316661567A5020517835 @default.
- W4316661567 hasAuthorship W4316661567A5025596555 @default.
- W4316661567 hasAuthorship W4316661567A5040286940 @default.
- W4316661567 hasAuthorship W4316661567A5040500028 @default.
- W4316661567 hasAuthorship W4316661567A5056183755 @default.
- W4316661567 hasAuthorship W4316661567A5060069116 @default.
- W4316661567 hasBestOaLocation W43166615671 @default.
- W4316661567 hasConcept C10730799 @default.
- W4316661567 hasConcept C114851261 @default.
- W4316661567 hasConcept C121608353 @default.
- W4316661567 hasConcept C126322002 @default.
- W4316661567 hasConcept C185592680 @default.
- W4316661567 hasConcept C20251656 @default.
- W4316661567 hasConcept C2777292972 @default.
- W4316661567 hasConcept C2780110267 @default.
- W4316661567 hasConcept C2780854706 @default.
- W4316661567 hasConcept C502942594 @default.
- W4316661567 hasConcept C530470458 @default.
- W4316661567 hasConcept C55885012 @default.
- W4316661567 hasConcept C62231903 @default.
- W4316661567 hasConcept C71924100 @default.
- W4316661567 hasConcept C86803240 @default.
- W4316661567 hasConcept C89423630 @default.
- W4316661567 hasConceptScore W4316661567C10730799 @default.
- W4316661567 hasConceptScore W4316661567C114851261 @default.
- W4316661567 hasConceptScore W4316661567C121608353 @default.
- W4316661567 hasConceptScore W4316661567C126322002 @default.
- W4316661567 hasConceptScore W4316661567C185592680 @default.
- W4316661567 hasConceptScore W4316661567C20251656 @default.
- W4316661567 hasConceptScore W4316661567C2777292972 @default.
- W4316661567 hasConceptScore W4316661567C2780110267 @default.
- W4316661567 hasConceptScore W4316661567C2780854706 @default.
- W4316661567 hasConceptScore W4316661567C502942594 @default.
- W4316661567 hasConceptScore W4316661567C530470458 @default.
- W4316661567 hasConceptScore W4316661567C55885012 @default.
- W4316661567 hasConceptScore W4316661567C62231903 @default.
- W4316661567 hasConceptScore W4316661567C71924100 @default.
- W4316661567 hasConceptScore W4316661567C86803240 @default.
- W4316661567 hasConceptScore W4316661567C89423630 @default.
- W4316661567 hasLocation W43166615671 @default.
- W4316661567 hasOpenAccess W4316661567 @default.
- W4316661567 hasPrimaryLocation W43166615671 @default.
- W4316661567 hasRelatedWork W2779586130 @default.
- W4316661567 hasRelatedWork W3015481613 @default.
- W4316661567 hasRelatedWork W3041162057 @default.
- W4316661567 hasRelatedWork W3165667851 @default.
- W4316661567 hasRelatedWork W4316661567 @default.